Introduction: The need for ARV (Anti Retro Viral) for the population aged 15-49 years increased from 145,706 in 2011 to 248,903 in 2016. People with HIV/AIDS who received ARVs were estimated at 16.60% in 2011 increased to 18% in 2016. In Indonesia up to September 2014, there were 108,060 people with HIV/AIDS who received ARV therapy from 33 provinces and 300 districts / cities. There were 19,670 people with HIV/AIDS who stopped ARV, 15,046 were not followed up due to various causes and as many as 14,547 died. Methods: This research used a quasi-experimental methods with non equivalent control group design and used a pretest, posttest 1 and posttest 2. There was two groups, the first group was treated using SMS (Short Message Service) reminder and leaflets and the second group was treated with the usual method (counselling). Results: Research with the Mann-Whitney statistical test shows that after 1 month of treatment, there was differences in the average score of knowledge (p value = 0.001), attitude (p value = 0.008), and adherence of Antiretroviral Consumption (p value = 0.010) between the intervention group and the control group. After 2 months of treatment, there was differences in the average knowledge score (p value = 0.001), attitude (p value = 0.001), and adherence of Antiretroviral Consume (p value = 0.001) between the intervention group and the control group. Conclusion: There is the interventions that able to improve the knowledge, attitudes and adherence of taking antiretroviral at PLWHA.