Recently RESS method has been used by researchers to produce fine particles for pharmaceutical drug substances. Since RESS technology acknowledges a lot of benefits compare to conventional method of ginger extraction. Therefore, the objective of this research is to produce direct solid oil particles formation from ginger rhizome which contains valuable compounds by using RESS-CO2 process and to study the effect of pressure and temperature on extraction yield. RESS experiments were carried out at various extraction pressure of 3000, 4000, 5000, 6000 and 7000psi and at different extraction temperature of 40, 45, 50, 55, 60, 65 and 70°C, respectively for 40 minutes extraction time and constant flowrate (24ml/min).From the studies conducted, it was found that extraction pressure is an important factor that can affect particle size and extraction yield. By increasing the extraction pressure, the extraction yield was found to increase with increasing of pressure at constant temperature, but extraction yield was found to decrease with increasing temperature. The highest extraction yield is 2.41% obtained at extraction pressure of 6000psi and constant extraction temperature of 65°C.