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Novel Multidisciplinary Salivary Gland Society (MSGS) Questionnaire: An International Consensus

Buchholzer S 1 , Faure F 2 , Tcheremissinoff L 3 , Herrmann FR 4 , Lombardi T 5 , Ng SK 6 Show all authors , Lopez JM 7 , Borner U 8 , Witt RL 9 , Irvine R 10 , Abboud O 11 , Cernea CR 12 , Ghan S 13 , Matsunobu T 14 , Ahmad Z 14 , Morton R 15 , Anicin A 16 , Magdy EA 17 , Al Abri R 18 , Konstantinidis I 19 , Capaccio P 20 , Klein H 21 , Poorten VV 22 , Lombardi D 23 , Lyons B 24 , Al Rand H 25 , Liao G 26 , Kim JK 27 , Subha S 28 , Su RY 29 , Su CH 30 , Boselie F 31 , Andre R 32 , Seebach JD 33 , Marchal F 31

Affiliations 

  • 1 Department of Maxillofacial Surgery and Oral Medicine and Pathology, Geneva University Hospitals, Geneva, Switzerland
  • 2 Otorhinolaryngology, Head and Neck Surgery Department, Hospices Civils de Lyon, Lyon, France
  • 3 European Sialendoscopy Training Center, Geneva, Switzerland
  • 4 Division of Geriatrics, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
  • 5 Oral Medicine and Oral and Maxillofacial Pathology Unit, Division of Oral Maxillofacial Surgery, Department of Surgery, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
  • 6 Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong, SAR, China
  • 7 Department of Otorhinolaryngology-Head and Neck Surgery, Centre Hospitalier de Perpignan, Perpignan, France
  • 8 Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  • 9 Christiana Care, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A
  • 10 Division of Otolaryngology, Department of Surgery, University of Calgary, Calgary, Alberta, Canada
  • 11 Division of Otolaryngology-Head and Neck Surgery, University of Montreal, Hôpital du Sacré-Coeur de Montréal, Montreal, Canada
  • 12 Department of Surgery, University of São Paulo School of Medicine, São Paulo, Brazil
  • 13 Department of Otolaryngology, Deenanath Mangeshkar Hospital and Research Center, Pune, India
  • 14 Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Nipppon Medical School, Tokyo, Japan
  • 15 Department of Otolaryngology Head and Neck Surgery, Counties Manukau District Health Board, Auckland, New Zealand
  • 16 Department of Otorhinolaryngology and Cervicofacial Surgery University Medical Centre Ljubljana, Ljubljana, Slovenia
  • 17 Department of Otorhinolaryngology-Head & Neck Surgery, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • 18 Department of Surgery, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
  • 19 Hellenic Rhinologic Society, Thessaloniki, Greece
  • 20 Department of Biomedical, Surgical and Dental Sciences, University of Milan, ENT Clinic Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
  • 21 Faculty of Medicine, Sialendoscopy and Minimal Invasive Surgery Service, Rambam Health Care Campus, Haifa, Israel
  • 22 Head and Neck Surgery, University Hospitals Leuven-Department of Oncology, Section Head and Neck Oncology, KU Leuven, Leuven, Belgium
  • 23 Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy
  • 24 Director ENT Head and Neck Surgery and Skull Base Surgery, St. Vincent's Hospital, Melbourne, Australia
  • 25 Department of Otorhinolaryngology, Dr. Sulaiman Al Habib Hospital, Dubai, United Arab Emirates
  • 26 Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, PR China
  • 27 Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea
  • 28 Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Malaysia
  • 29 Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR
  • 30 Department of Otolaryngology Head and Neck Surgery, Mackay Memorial Hospital, Taipei, Taiwan
  • 31 Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospitals, Geneva, Switzerland
  • 32 Department of Dermatology, Geneva University Hospitals, Geneva, Switzerland
  • 33 Division of Clinical Immunology and Allergy, Department of Medical Specialties, University Hospitals and Medical Faculty, Geneva, Switzerland
Laryngoscope, 2022 02;132(2):322-331.
PMID: 34236085 DOI: 10.1002/lary.29731

Abstract

OBJECTIVES: First, establishment and validation of a novel questionnaire documenting the burden of xerostomia and sialadenitis symptoms, including quality of life. Second, to compare two versions regarding the answering scale (proposed developed answers Q3 vs. 0-10 visual analogue scale Q10) of our newly developed questionnaire, in order to evaluate their comprehension by patients and their reproducibility in time.

STUDY DESIGN: The study is a systematic review regarding the evaluation of the existing questionnaire and a cohort study regarding the validation of our new MSGS questionnaire.

MATERIALS AND METHODS: A Multidisciplinary Salivary Gland Society (MSGS) questionnaire consisting of 20 questions and two scoring systems was developed to quantify symptoms of dry mouth and sialadenitis. Validation of the questionnaire was carried out on 199 patients with salivary pathologies (digestive, nasal, or age-related xerostomia, post radiation therapy, post radioiodine therapy, Sjögren's syndrome, IgG4 disease, recurrent juvenile parotitis, stones, and strictures) and a control group of 66 healthy volunteers. The coherence of the questionnaire's items, its reliability to distinguish patients from healthy volunteers, its comparison with unstimulated sialometry, and the time to fill both versions were assessed.

RESULTS: The novel MSGS questionnaire showed good internal coherence of the items, indicating its pertinence: the scale reliability coefficients amounted to a Cronbach's alpha of 0.92 for Q10 and 0.90 for Q3. The time to complete Q3 and Q10 amounted, respectively, to 5.23 min (±2.3 min) and 5.65 min (±2.64 min) for patients and to 3.94 min (±3.94 min) and 3.75 min (±2.11 min) for healthy volunteers. The difference between Q3 and Q10 was not significant.

CONCLUSION: We present a novel self-administered questionnaire quantifying xerostomia and non-tumoral salivary gland pathologies. We recommend the use of the Q10 version, as its scale type is well known in the literature and it translation for international use will be more accurate. Laryngoscope, 132:322-331, 2022.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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