Phylogenomic analysis of SARS-CoV-2 from third wave clusters in Malaysia reveals dominant local lineage B.1.524 and persistent spike mutation A701V

Suppiah J 1 , Kamel KA 1 , Mohd-Zawawi Z 1 , Afizan MA 1 , Yahya H 2 , Md-Hanif SA 3 Show all authors , Thayan R 1

Affiliations 

  • 1 Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia
  • 2 Disaster, Outbreak, Crisis and Emergency Management Sector, Surveillance Section, Disease Control Division, Ministry of Health Malaysia, Federal Government Administrative Centre, Putrajaya, Malaysia
  • 3 International Travel and Health Regulation Sector, Surveillance Section, Disease Control Division, Ministry of Health Malaysia, Federal Government Administrative Centre, Putrajaya, Malaysia
Trop Biomed, 2021 Sep 01;38(3):289-293.
PMID: 34362872 DOI: 10.47665/tb.38.3.070

Abstract

The emergence of a third wave of COVID-19 infection in Malaysia since September 2020 has led to imminent changes in public health prevention and control measures. As high as 96.2% of registered COVID-19 cases and 88.5% of confirmed deaths in Malaysia occurred during this third wave of infection. A phylogenomic study on 258 SARS-CoV-2 full genomes from February 2020-February 2021 has led to the discovery of a novel Malaysian lineage B.1.524. This lineage contains another spike mutation A701V that co-exists with the D614G spike mutation that was predominant in most of the third-wave clusters. The study provides vital genomic insights on the rapid spread of the SARS-CoV-2 variants in Malaysia in conjunction with the presence of a dominant SARS-CoV-2 lineage during the third wave of COVID-19 infection.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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