Telomeres are specialized DNA complexes found at the end of all chromosomes. Human, as a member of eukaryotic cells, requires telomeres to maintain the length and the stability of chromosomes. Telomeres lose their non-coding DNA sequence to protect the genetic information on the chromosomes. Shortening of telomeres occurs in most somatic cells after sufficient cell division in a human lifetime. Normal haemopoietic cells or stem cells possess telomerase enzyme to restore telomeres and allow further replication. Telomere dysfunction is the origin of several degenerative disorders and also predispose to cancer. Roles of telomere in carcinogenesis and ageing related disorders are reviewed.
Introduction: Violence Against Women has increasingly been recognized in the international areas as an obstacle to women’s development and it may have a myriad of devastating consequences on women’s long or short- term health and wellbeing. The study explored the highlight the prevalence and health effects of Violence Against Women which might reflect the probable causes, the types of injuries, leading factors and consequences of the violence. Methods:Hospital based case study, which was referred to forensic department, Mandalay General Hospital from 1st Jan 2000 to 30th Sept 2000. Personal interview and medical examination of 50-100 victims, girls & women, who were phys-ically and sexually violated was done. Results: Total 92 patients were interviewed and examined, prevalence of dif-ferent age ranging from 5 to 56, were physically and sexually violated during the study period, 62 patients were phys-ically assaulted, and 30 victims were sexually violated. 20-40 age group is more commonly conflicted by physical violence 69.3%) while 10-20 age group were commonly conflicted by sexual violence (56.6%). Pattern of different types of injury and locations are also recorded as a consequence of physical assault and commonest injury is bruise (47%). Commonest location is injury over head & neck (61.8%). Relationship to perpetrator were recorded, physical assaults were commonly by spouse (39%) while sexual assaults were acquaintance (58%). Events leading to violence at home are recorded as nuclear family and alcohol consumption is more common, fights were most common events in community setting. Conclusion: Violence Against Women is neither prevalent nor uncommon in Myanmar. In this study, all forms of injuries were recorded and among them the commonest injuries were bruises, the event leading to violence recorded as fights, alcohol consumption, nuclear family was most common. Violence has a psychological impact on other members of the family, particularly children. However, a multi-sectoral approach has become a necessity to create a happy family, society and nation. It could be achieved by uplifting the socio-economic status of the family, practising the religious teachings and abiding within the framework of the laws. The Trans-National Committed should be formed to effectively minimize trafficking in women and children in the Region.
Introduction: Dengue is caused by dengue virus (DENV) which is a member of the genus Flavivirus of the family Flaviviridae. The prevalence of dengue has been increasing all over the world especially in Southeast Asia and Western Pacific regions. In 2016 - 2017 dengue outbreaks were reported in Sandakan and Kudat of Sabah, Malay-sia. The aim of this study was to determine the serotypes of dengue viruses circulating in these two sites during the outbreaks. Methods: A total of 200 dengue patients’ sera tested positive with NS1 and IgM & IgG rapid test (PanBio) were collected from Hospital Duchess of Kent Sandakan and Hospital Kudat between June 2016 and December 2017. PCR was done at the Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah. One-Step Reverse transcriptase PCR (RT-PCR) and nested PCR was performed using C-prM amplimers designed by Lanciotti et al and later redesigned by Chien et al, followed by sequencing some of the PCR products. Results: Out of 200 sera tested 128 were PCR positive. All the four dengue serotypes were detected with PCR products with specific sizes in gel electrophoresis. However, in four samples, no serotype-specific band was amplified by the nested PCR, while they were dengue-positive in RT-PCR showing 511 base pair amplicon. Sequencing results revealed all four samples were found to belong to DENV4. The sequences of these samples were aligned with that of DENV 4 reverse primer rTS4. The DENV4 specific primer rTS4 was found to have four mismatched nucleotides to the DENV4 sequences. Conclusion: There was a co-circulation of DENV1 to 4 in Sandakan and Kudat in the study period. DENV1 was the predominant serotype. DENV4 specific C-prM primer rTS4 should be redesigned for the local DENV4 strain in Sabah in future research.
Introduction: This study aimed to investigate the relationships between parental effort to control the child’s food intake among primary school children with parents’ ‘control’, ‘restriction’ and ‘reward’ on limiting children to eat unhealthy foods. Methods: Data were collected among 485 primary school children and their parents. Questionnaire for Obesity survey among primary school children was used to document on the child’s daily food intake for one week. Results: All predictor variables are significant at the p