MyMedR

This paper reports a study in the rat of the changes in the plasma albumin level following laparotomy, and their correlation with the concentrations of extravascular albumin in the area of the operation wound and in the liver.

SUMMARY: The pathogenesis of postoperative hypoalbuminaemia remains a controversial and poorly understood topic. In the present study the changes in the plasma albumin level following laparotomy have been investigated by immunological methods and correlated with the concentrations of extravascular albumin in the operation wound site and in the liver. There was a fall in the plasma albumin level, accompanied by an increase in the extravascular albumin concentration at the laparotomy wound site, with no alteration in the concentration of albumin in the liver. This work confirms that postoperative hypoalbuminaemia is due to accumulation of albumin in the wound site. Increased capillary permeability is suggested as a cause of the excessive loss of plasma albumin into the surgically injured site. The role and subsequent fate of the extravascular albumin in the wound area are also discussed.

Ecological assessment of vitamin A status of primary school children in Ulu Trengganu

Chandrasekharan N

Med J Malaysia, 1975 Mar;30(3):187-94.

PMID: 1160677

Changes in body fluid distribution in experimental protein malnutrition

Chandrasekharan N, Ho CL

Med J Malaysia, 1976 Jun;30(4):266-72.

PMID: 824533

Fulltext An inquiry into the state of food, nutrition and health in plantations

Chandrasekharan N, Marimuthu T

Med J Malaysia, 1980 Mar;34(3):226-9.

PMID: 7412663

Food expenses accounted for 66% 54% of the total income in the two plantations. The nutritional value of foods purchased and consumed and the adequacy of nutrient intakes in two plantations was studied. The diets were found to be inadequate in calories, protein, calcium, iron and riboflavin. Carbohydrates provided the bulk of the calories. The significance of the findings are discussed.

Fulltext A study of liver reserves of vitamin A in Malaysians

Chandrasekharan N

Malays J Pathol, 1981 Aug;4:43-7.

PMID: 7186602

Fulltext Health laboratory services in Malaysia

Chandrasekharan N

Med J Malaysia, 1982 Sep;37(3):197-204.

PMID: 7176996

The chemical pathology laboratory services in Malaysia

Chandrasekharan N

Malays J Pathol, 1983 Aug;6:9-14.

PMID: 6599868

Fulltext Medical research in Malaysia

Chandrasekharan N

Med J Malaysia, 1984 Mar;39(1):1-4.

PMID: 6513835

The variation of glucose tolerance in a multi racial population

Ch'ng SL, Chandrasekharan N

Ann Acad Med Singap, 1985 Apr;14(2):223-8.

PMID: 4037680

The pattern of plasma and urine sugar changes after 50g glucose load in 1900 Malaysians (522 males and 1378 females) consisting predominantly of Malays, Chinese and Indians were studied. The data were analysed using Statistical Package for Social Sciences (SPSS). The results show bimodal distribution of 120 min. plasma sugar values in the age groups 21 years and above and trimodal distribution in most groups above 40 years. The mean 120 minutes plasma sugar cut-off values for nondiabetics (ND), impaired glucose tolerance (IGT), and diabetics (DM) of 8.4 and 11.1 mmol/l respectively were close to the values recommended by the National Diabetic Data Group (NDDG). Fifty two percent of all subjects showed peaked plasma sugar values at 60 minutes (14% of them had IGT, 12% DM), 25% peaked at 30 minutes (98% of them were ND). The rest showed peaked values at 90 minutes (17%), 120 minutes (4%) and 150 minutes (2%) and from this group forty two percent were DM and 23% had IGT. Reliance on urine sugar qualitative tests could misclassify 7.3% of subjects (predominantly elderly females) with hyperglycaemia of greater than 11 mmol/l. This study shows that in the 50 g glucose tolerance test, the NDDG criteria for ND, IGT, DM is still applicable to the Malaysian population. The sampling time could be reduced to four points at 0, 60, 90, and 120 minutes. Blood analysis is the preferred method for the diagnosis of hyperglycaemia in elderly females.

Fulltext Declining post-mortems: a cause for concern

Pathmanathan R, Chandrasekharan N

Med J Malaysia, 1985 Dec;40(4):267-70.

PMID: 3842725

Fulltext The palm oil debate--health considerations

Chandrasekharan N

Med J Malaysia, 1988 Mar;43(1):1-3.

PMID: 3244313

Fulltext Digoxin toxicity: clinical and laboratory assessment

Ong HT, Ch'ng SL, Masduki A, Chandrasekharan N

Med J Malaysia, 1989 Dec;44(4):296-301.

PMID: 2520037

A prospective study to correlate clinical digoxin toxicity with serum digoxin levels was carried out in 67 patients of whom 24 were clinically toxic and 43 were asymptomatic. The patients were clinically diagnosed to be toxic based on typical cardiac arrhythmias (n = 11) or non-cardiac symptoms (n = 13). Blood samples were collected at least six hours after the last digoxin dose and the sera assayed for digoxin using a radioimmunoassay method. The mean serum digoxin level in the toxic group (x1 = 2.09 +/- 1.28 ng/ml) was significantly higher than in the non-toxic group (x2 = 1.20 +/- 0.75 ng/ml), p less than 0.01. All the non-toxic patients had serum digoxin levels below 3 ng/ml. However, there was a considerable overlap of serum digoxin levels between the two groups of patients. Serum level cannot be the sole criterion in diagnosing digoxin toxicity. Nevertheless, raised serum digoxin levels especially above 3 ng/ml, in the presence of suggestive clinical features is strongly suggestive of toxicity.

Fulltext Toxicovigilance--the need for concern

Chandrasekharan N

Med J Malaysia, 1989 Dec;44(4):273-4.

PMID: 2520034

Fulltext Renal disease in Malaysia: problems and prospects

D'Cruz F, Chandrasekharan N

Med J Malaysia, 1990 Jun;45(2):88-91.

PMID: 2152024

Fulltext An appraisal of the nutritional and health aspects of palm oil

Chandrasekharan N

Med J Malaysia, 1992 Jun;47(2):93-7.

PMID: 1494339

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