Displaying publications 1 - 20 of 21 in total

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  1. Fulltext Changing concepts in lipid nutrition in health and disease
    Chandrasekharan N
    Med J Malaysia, 1999 Sep;54(3):408-27; quiz 428.
    PMID: 11045075
    Fat remains a hot topic because of concerns over associations between consumption of fats and the incidence of some chronic conditions including coronary artery disease, diabetes, cancer and obesity. Dietary fats serve multiple purposes. The effects of dietary fats generally reflect the collective influences of multiple fatty acids in the diet or food. This presentation highlights some recent developments on the role of dietary fats and oils in health and disease. Debate continues over the role of dietary modification in coronary prevention by lipid lowering. The degree to which a recommended diet will result in health benefits for an individual is difficult to predict, because the outcome will depend on the influence of other factors such as a person's genetic constitution, level of physical activity and total diet composition. There can now be little doubt about the importance of genetic factors in the etiology of cardiovascular disease, diabetes, obesity and cancer. The importance of antioxidant status in the prevention of cardiovascular disease as well as many cancers is being increasingly recognised. It is now evident that not all saturated fatty acids are equally cholesterolemic. Recent accounts evaluating palm oil's effects on blood lipids and lipoproteins suggest that diets incorporating palm oil as the major dietary fat do not raise plasma total and LDL cholesterol levels to the extent expected from its fatty acid composition. Palm oil is endowed with a good mixture of natural antioxidants and together with its balanced composition of the different classes of fatty acids, makes it a safe, stable and versatile edible oil with many positive health and nutritional attributes. In recent times, adverse health concerns from the consumption of trans fatty acids arising from hydrogenation of oils and fats have been the subject of much discussion and controversy. Trans fatty acids when compared with cis fatty acids or unhydrogenated fats have been shown to lower serum HDL cholesterol, raise serum LDL cholesterol and when substituted for saturated fatty acids, increase lipoprotein Lp (a) level, an independent risk factor for the development of coronary heart disease. The idea of which foods, nutrients and supplements are "healthy" is often being amended as new scientific data is presented and then simplified for the consumers. What was once perceived as a healthy diet is often no longer considered as such and vice versa. Dietary recommendations have to change with time and the evidence available. Nutritional recommendations should encourage eating a great variety of nutrient sources within our food supply in moderation. Various lifestyle options to improve health should also be promoted.
  2. Fulltext An appraisal of the nutritional and health aspects of palm oil
    Chandrasekharan N
    Med J Malaysia, 1992 Jun;47(2):93-7.
    PMID: 1494339
  3. Fulltext Medical research in Malaysia
    Chandrasekharan N
    Med J Malaysia, 1984 Mar;39(1):1-4.
    PMID: 6513835
  4. Fulltext Toxicovigilance--the need for concern
    Chandrasekharan N
    Med J Malaysia, 1989 Dec;44(4):273-4.
    PMID: 2520034
  5. The chemical pathology laboratory services in Malaysia
    Chandrasekharan N
    Malays J Pathol, 1983 Aug;6:9-14.
    PMID: 6599868
  6. Fulltext Health laboratory services in Malaysia
    Chandrasekharan N
    Med J Malaysia, 1982 Sep;37(3):197-204.
    PMID: 7176996
  7. Fulltext The palm oil debate--health considerations
    Chandrasekharan N
    Med J Malaysia, 1988 Mar;43(1):1-3.
    PMID: 3244313
  8. Fulltext A study of liver reserves of vitamin A in Malaysians
    Chandrasekharan N
    Malays J Pathol, 1981 Aug;4:43-7.
    PMID: 7186602
  9. Metabolic changes in protein malnutrition
    Chandrasekharan N
    Med J Malaya, 1971 Jun;25(4):269-72.
    PMID: 4261298
  10. Ecological assessment of vitamin A status of primary school children in Ulu Trengganu
    Chandrasekharan N
    Med J Malaysia, 1975 Mar;30(3):187-94.
    PMID: 1160677
  11. Nutrition in Malaya
    Chandrasekharan N
    N Y State J Med, 1970 Aug 1;70(15):2010-6.
    PMID: 5270540
  12. Serum protein changes during early pregnancy in Malayan women
    Chandrasekharan N
    Med J Malaya, 1968 Sep;23(1):47-50.
    PMID: 4237556
  13. The Malaysian sea turtle eggs as a source of vitamin A
    Chandrasekharan N
    Med J Malaya, 1969 Mar;23(3):214-5.
    PMID: 4240077
  14. An Experimental Study on the Pathogenesis of Postoperative Hypoalbuminaemia1
    Chandrasekharan N
    Aust N Z J Surg, 1972 Feb;38(3):292-297.
    PMID: 29265290 DOI: 10.1111/j.1445-2197.1972.tb05640.x
    This paper reports a study in the rat of the changes in the plasma albumin level following laparotomy, and their correlation with the concentrations of extravascular albumin in the area of the operation wound and in the liver.

    SUMMARY: The pathogenesis of postoperative hypoalbuminaemia remains a controversial and poorly understood topic. In the present study the changes in the plasma albumin level following laparotomy have been investigated by immunological methods and correlated with the concentrations of extravascular albumin in the operation wound site and in the liver. There was a fall in the plasma albumin level, accompanied by an increase in the extravascular albumin concentration at the laparotomy wound site, with no alteration in the concentration of albumin in the liver. This work confirms that postoperative hypoalbuminaemia is due to accumulation of albumin in the wound site. Increased capillary permeability is suggested as a cause of the excessive loss of plasma albumin into the surgically injured site. The role and subsequent fate of the extravascular albumin in the wound area are also discussed.

  15. Fulltext An inquiry into the state of food, nutrition and health in plantations
    Chandrasekharan N, Marimuthu T
    Med J Malaysia, 1980 Mar;34(3):226-9.
    PMID: 7412663
    Food expenses accounted for 66% 54% of the total income in the two plantations. The nutritional value of foods purchased and consumed and the adequacy of nutrient intakes in two plantations was studied. The diets were found to be inadequate in calories, protein, calcium, iron and riboflavin. Carbohydrates provided the bulk of the calories. The significance of the findings are discussed.
  16. Fulltext Declining post-mortems: a cause for concern
    Pathmanathan R, Chandrasekharan N
    Med J Malaysia, 1985 Dec;40(4):267-70.
    PMID: 3842725
  17. Fulltext Renal disease in Malaysia: problems and prospects
    D'Cruz F, Chandrasekharan N
    Med J Malaysia, 1990 Jun;45(2):88-91.
    PMID: 2152024
  18. The variation of glucose tolerance in a multi racial population
    Ch'ng SL, Chandrasekharan N
    Ann Acad Med Singap, 1985 Apr;14(2):223-8.
    PMID: 4037680
    The pattern of plasma and urine sugar changes after 50g glucose load in 1900 Malaysians (522 males and 1378 females) consisting predominantly of Malays, Chinese and Indians were studied. The data were analysed using Statistical Package for Social Sciences (SPSS). The results show bimodal distribution of 120 min. plasma sugar values in the age groups 21 years and above and trimodal distribution in most groups above 40 years. The mean 120 minutes plasma sugar cut-off values for nondiabetics (ND), impaired glucose tolerance (IGT), and diabetics (DM) of 8.4 and 11.1 mmol/l respectively were close to the values recommended by the National Diabetic Data Group (NDDG). Fifty two percent of all subjects showed peaked plasma sugar values at 60 minutes (14% of them had IGT, 12% DM), 25% peaked at 30 minutes (98% of them were ND). The rest showed peaked values at 90 minutes (17%), 120 minutes (4%) and 150 minutes (2%) and from this group forty two percent were DM and 23% had IGT. Reliance on urine sugar qualitative tests could misclassify 7.3% of subjects (predominantly elderly females) with hyperglycaemia of greater than 11 mmol/l. This study shows that in the 50 g glucose tolerance test, the NDDG criteria for ND, IGT, DM is still applicable to the Malaysian population. The sampling time could be reduced to four points at 0, 60, 90, and 120 minutes. Blood analysis is the preferred method for the diagnosis of hyperglycaemia in elderly females.
  19. Changes in body fluid distribution in experimental protein malnutrition
    Chandrasekharan N, Ho CL
    Med J Malaysia, 1976 Jun;30(4):266-72.
    PMID: 824533
  20. Dietary intake of women students in the University of Malaya
    Chandrasekharan N, Bhattathiry EP
    Am J Clin Nutr, 1968 Feb;21(2):183-4.
    PMID: 5642892
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