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  1. Fulltext Polydopamine-Modified Polycaprolactone Scaffolds Loading Metal Nanoparticles for Bone Tissue Engineering
    Liu T, Hassan A, Yousif Alrawas MZ, Cui C, Ariffin Z
    ACS Omega, 2024 Nov 19;9(46):45652-45662.
    PMID: 39583686 DOI: 10.1021/acsomega.4c06268
    Recent advancements in materials synthesis and processing technology, coupled with a deeper understanding of bone nanoscale structure and biology, have provided new avenues for designing bioactive materials in bone tissue regenerative medicine. This Review focuses on the design and application of polydopamine-modified polycaprolactone scaffolds loading metal nanoparticles for bone tissue engineering. We explore their antibacterial properties and their ability to guide cell behavior. Specifically, we discuss the synthesis techniques, protein deposition, morphology variations, and interactions with the extracellular matrix of these scaffolds and biocompatibility and efficacy in promoting bone tissue regeneration in vitro and in vivo. Challenges and unmet needs are reviewed in the development of polymer- and metal-based materials for bone tissue engineering.
  2. Pharmacological Action and Research Progress of Taraxasterol
    Zhang Y, BinShaari R, Nawi MABA, Bin Hassan A, Cui C
    Curr Pharm Biotechnol, 2024;25(14):1767-1777.
    PMID: 38178677 DOI: 10.2174/0113892010276692231220103636
    Primarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol. We endeavor to provide an exhaustive review of the experimental subjects, intervention components, distinct action modalities, contributing factors, and protein pathway expressions associated with taraxasterol, systematically represented via diagrams and tables. Such a schematic representation encourages a continued academic dialogue concerning taraxasterol's pharmacological characteristics. This review is envisioned as a practical guide for the selection of experimental subjects and methodologies in prospective research. It is intended to further illuminate taraxasterol's pharmacodynamics, thereby offering theoretical and empirical justification for its clinical application.
  3. Dosage-dependent effects of Semen Ziziphi Spinosae on post-acidification inhibition, protein structure and functional properties of goat milk fermented by Lactiplantibacillus plantarum
    Wang Q, Nie M, Yang T, Che H, Shi Y, Cui C, et al.
    J Sci Food Agric, 2026 Nov 03.
    PMID: 42978181 DOI: 10.1002/jsfa.71128
    BACKGROUND: This study aimed to prepare fermented goat milk yogurt (GMY) with graded Semen Ziziphi Spinosae (SZS) supplementation (0.0-2.5 g kg-1), and to explore the regulatory effects and underlying molecular mechanisms of SZS on gel properties, physicochemical quality and protein conformation of GMY co-fermented by Lactiplantibacillus plantarum L3 and commercial starter (YO-MIX 883 containing Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus). Physicochemical and antioxidant properties were assayed. Spectroscopic measurements coupled with particle-size and zeta-potential analyses characterized protein-conformational and colloidal-structure variations.

    RESULTS: All GMY exhibited post-acidification during storage. The amount of 0.5-1.0 g kg-1 SZS raised titratable acidity, while 1.5-2.5 g kg-1 restrained acid accumulation. SZS dose-dependently increased hardness and consistency and reduced cohesiveness and adhesiveness; 2.0-2.5 g kg-1 groups showed the densest gel. SZS decreased particle size and raised absolute zeta potential to stabilize casein micelles, reduced L* and elevated total color difference (ΔE), turning samples creamy yellow. It remarkably improved DPPH and ABTS scavenging capacity, with the 2.5 g kg-1 group hitting 93.30 g 100 g-1. Fourier-transform infrared (FTIR), Raman and intrinsic fluorescence spectroscopy verified protein secondary structure rearrangement and reconstructed intermolecular forces. It was found 2.0 g kg-1 was the optimal dosage; overdose disrupted colloidal and protein conformational stability. SZS optimized casein polysaccharide networks through hydrogen, hydrophobic and electrostatic interactions.

    CONCLUSION: Appropriate SZS supplementation achieved optimal quality regulation of GMY with substantially enhanced storage stability, gel texture and antioxidant activity. This study uncovered the molecular mechanism by which natural plant bioactive compounds improve fermented milk quality via regulating protein conformation and non-covalent interactions, providing theoretical support for the targeted formulation design of functional fermented dairy products. © 2026 Society of Chemical Industry.

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