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Fulltext Proposal for a Radiological Classification System for Carpo-Metacarpal Joint Dislocations with or without Fractures

Pundkare GT, Deshpande SS

Malays Orthop J, 2018 Jul;12(2):42-46.
PMID: 30112128 DOI: 10.5704/MOJ.1807.008

Introduction: Though complex injuries like CarpoMetacarpal (CMC) Joint dislocations represent only 1% of all hand injuries, they have disabling impact on the functional status of patient. There are no reports in the literature classifying disabling complex injuries like CMC joint dislocations presumably because of low incidence. We propose a new classification through retrospective analysis of patients, along with literature search. Materials and Methods: A new classification system has been proposed and designed at our clinical unit and applied to eight patients with CMC joint dislocations. All patients were treated with open reduction with Kirschner wire fixation. At follow-up all these patients were analysed for radiographic assessments and functional scores. Results: The proposed classification identifies three types of dislocations and an additional complex category to supplement any basic type. The direction of dislocation describes the types as Type A: Dorsal, Type B: Volar and Type C: Divergent. Among the eight patients in our study, we had two of Type A, two Type B, three Type B.1, one Type C. 1. These patients had average follow-up of 18 months. The quick DASH score improved from 75.76 at 6 weeks to 1.9 at 18 months. We also did intra-observer and inter-observer reliability which scored 1. Conclusion: Our proposal is a reproducible, simple, comprehensive and practical classification, easily remembered and communicated among colleagues. It is clinically relevant as it helps us in planning surgical management and prognostic evaluation.
Comparative evaluation of three types of denture base materials with saliva substitute before and after thermocycling: An in vitro study

Jadhav V, Deshpande S, Radke U, Mahale H, Patil PG

J Prosthet Dent, 2021 Oct;126(4):590-594.
PMID: 33012529 DOI: 10.1016/j.prosdent.2020.07.014

STATEMENT OF PROBLEM: Xerostomia refers to the decrease in the quality and quantity of saliva. In denture wearers, xerostomia affects the retention of the denture because of lack of wettability of the denture base. However, which denture base resin materials are best wetted by artificial salivary substitutes is unclear.
PURPOSE: The purpose of this in vitro study was to determine the wetting properties of 3 different commercially available denture base resin materials with artificial salivary substitute by using contact angle measurements and to compare these properties before and after thermocycling.
MATERIAL AND METHODS: A total 120 specimens were fabricated with 3 different denture base materials (n=40): heat-polymerized polymethylmethacrylate (DenTek), injection-molded nylon polyamide (Valplast), and microwave polymerized (VIPI WAVE). The advancing and receding contact angles were measured with a goniometer by using the WinDrop++ software program. The contact angle hysteresis was calculated from the advancing and receding contact angles values. The same specimens were subjected to thermocycling to measure the advancing and receding contact angles values. The comparative evaluation was carried out before and after thermocycling.
RESULTS: The mean ±standard deviation contact angles of the microwave-polymerized material were (62.40 ±1.21 degrees) advancing contact angle, (32.12 ±0.66 degrees) receding contact angle, and (30.28 ±1.40 degrees) contact angle of hysteresis. It was followed by the injection-molded nylon polyamide material, whose mean ±standard deviation contact angle values were (68.57 ±1.72 degrees) advancing contact angle, (43.02 ±1.39 degrees) receding contact angle, (26.27 ±2.05 degrees) contact angle hysteresis and high impact strength heat-polymerized polymethylmethacrylate material, whose mean ±standard deviation contact angle values were (69.81 ±0.16 degrees) advancing contact angle, (41.90 ±1.02 degrees) receding contact angle, and (27.91 ±0.97 degrees) contact angle hysteresis. The statistical analysis showed significant differences among contact angle values of the microwave-polymerized material as compared with the heat-polymerized polymethylmethacrylate and injection-molded nylon polyamide materials (P
Effect of Ball and Bar Attachment Type on Patient Satisfaction Using Two-Implant-Retained Mandibular Overdenture: A Crossover Randomized Clinical Trial

Deshpande S, Chandak A, Radke U, Mahalle H, Patil PG

J Maxillofac Oral Surg, 2022 Dec;21(4):1175-1179.
PMID: 36896084 DOI: 10.1007/s12663-022-01727-0

BACKGROUND: Considering the two-implant-retained overdenture as a first treatment of choice for edentulous mandible, patients using the overdentures need to be satisfied with the type of attachment used. The purpose of this study was to determine level of patient satisfaction with two-implant-retained mandibular overdentures opposing conventional maxillary complete denture using ball-socket and bar-clip attachments.
MATERIALS AND METHODS: In this within-subject crossover randomized clinical trial, total 20 edentulous patients were given conventional complete dentures for 3 months to use. All completed a satisfaction questionnaire before implant placement. They were randomly assigned to receive an overdenture retained by either ball or bar attachment. After 3 months satisfaction questionnaires were repeated, and crossover was done by changing the attachments. After use of 3 months of alternate attachments, patients were asked to complete the final questionnaires and asked to choose their preferred type. The patient satisfaction scores were recorded after using 3 months of conventional complete denture, 3 months of first attachment and 3 months of second attachment. Data were analyzed using Wilcoxon signed rank test. The P values were adjusted using Bonferroni multiple testing correction, and P
Fulltext An Assessment of the Training Program on Mental Health for Community Health Workers in Kashmir, India

Bashir A, Khan BA, Bhatia T, Shoib S, Ali I, Bashir U, et al.

Rev Cercet Interv Soc, 2023 Mar;80:7-17.
PMID: 37082026 DOI: 10.33788/rcis.80.1

In recent years mental health has emerged as a major health threat in low income countries like India. In response, mental health care has been integrated into primary health care, in turn creating a rising demand for trained and skillful mental health professionals. This study was conducted in district Budgam (J&K), India with the aim of providing training to community health workers (CHWs) and measuring the change using pre- and post-training evaluations. The pre and post tests were undertaken, assessing changes in mental health literacy at three different points of time: pre-training, post-training, and three month follow-up. Mental health literacy was assessed using the interviewer-administered Mental Health Literacy Survey. The training intervention was a five-day course based on a facilitator's manual developed specifically for community health workers in India. A total of 25 community health workers from rural areas of Budgam District (mostly Integrated Child Development Service supervisors), Health Educators and Anganwadi Workers, were engaged for the study. Findings demonstrate that the training course improved participants' ability to recognize any mental health disorders. There was a clear distinction between the level of awareness pre- and post- training. The results were statistically significant on various domains Ability to recognize disorders (Pre-post P= 0.001), Knowledge of the professional help available (Pre-post p= 0.000), Attitudes that promote the recognition or appropriate help-seeking behavior (Pre-post p= 0.000) (p<0.05). Further follow up after three months was done. The mixed findings from this study, suggesting the training course has potential to improve some aspects of mental health literacy among the CHWs, including their understanding of various mental health problems.
Broad neutralization response in a subset of HIV-1 subtype C-infected viraemic non-progressors from southern India

Nandagopal P, Bhattacharya J, Srikrishnan AK, Goyal R, Ravichandran Swathirajan C, Patil S, et al.

J Gen Virol, 2018 Mar;99(3):379-392.
PMID: 29458681 DOI: 10.1099/jgv.0.001016

Broadly neutralizing antibodies (bnAbs) have been considered to be potent therapeutic tools and potential vaccine candidates to enable protection against various clades of human immunodeficiency virus (HIV). The generation of bnAbs has been associated with enhanced exposure to antigen, high viral load and low CD4+ T cell counts, among other factors. However, only limited data are available on the generation of bnAbs in viraemic non-progressors that demonstrate moderate to high viraemia. Further, since HIV-1 subtype C viruses account for more than 50 % of global HIV infections, the identification of bnAbs with novel specificities is crucial to enable the development of potent tools to aid in HIV therapy and prevention. In the present study, we analysed and compared the neutralization potential of responses in 70 plasma samples isolated from ART-naïve HIV-1 subtype C-infected individuals with various disease progression profiles against a panel of 30 pseudoviruses. Among the seven samples that exhibited a neutralization breadth of ≥70 %, four were identified as 'elite neutralizers', and three of these were from viraemic non-progressors while the fourth was from a typical progressor. Analysis of the neutralization specificities revealed that none of the four elite neutralizers were reactive to epitopes in the membrane proximal external region (MPER), CD4-binding site and V1V2 or V3 glycan. However, two of the four elite neutralizers exhibited enhanced sensitivity towards viruses lacking N332 glycan, indicating high neutralization potency. Overall, our findings indicate that the identification of potent neutralization responses with distinct epitope specificities is possible from the as yet unexplored Indian population, which has a high prevalence of HIV-1 subtype C infection.