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  1. Goh SM, Dassanayake MK, Foan CC, Wiart C, Symonds R, Khoo TJ, et al.
    Microb Pathog, 2025 Jan;198:107134.
    PMID: 39566830 DOI: 10.1016/j.micpath.2024.107134
    BACKGROUND AND OBJECTIVES: Plants contain a wide variety of bioactive compounds, which have attracted the interest of researchers in finding novel sources of natural medicine. In the following paper, we aim to evaluate the antibacterial potential of extract fractions associated with Parkia speciosa pods and beans against human pathogenic bacteria.

    METHODS: Antimicrobial activity was determined with disc diffusion and broth microdilution assays against eight skin colonising microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia followed by further fractionation of the pods ethyl acetate fraction by column chromatography along with preparative thin-layer chromatography. Quantification of bacterial death mechanism was elucidated by the measurement of hole size in cell wall that has been induced by extract constituents via field-emission scanning electron microscopy (FESEM).

    RESULTS: Four fractions showed significant antimicrobial activity against the six microorganisms tested (p 

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