In this work, an innovative integrated system that is incorporated from solid oxide electrolysis cells and an oxygen separator membrane is assessed and optimized from the techno-economic aspects to respond to oxygen, hydrogen, and nitrogen demands for hospitals and other health care applications. Besides, a parametric comparison is conducted to apprehend the weights of parameters changes on the performance of criteria. Relying on the assessments, from the hydrogen production of 1 kg/s, 23.19 kg/s of oxygen, and 50.22 kg/s of nitrogen are produced. The parametric study shows that by raising the working temperature of the electrolyzer, the cell voltage variation has descending trend and the power consumption of the system is decreased by 19%. Finally, the results of multi-criteria optimization on the Pareto front reveal that in the optimal case, the system payback period is attained at about 5.32 years and the exergy efficiency of 92.47%, which are improved 16.6% and 16.2% compared to the base case, sequentially. Consequently, this system is proposed to consider as a cost-effective and reliable option towards its vital and valuable productions, in the pandemic period and after's.
Fibrinogen is one of the key proteins that participate in the protein corona composition of many types of nanoparticles (NPs), and its conformational changes are crucial for activation of immune systems. Recently, we demonstrated that the fibrinogen highly contributed in the protein corona composition at the surface of zeolite nanoparticles. Therefore, understanding the interaction of fibrinogen with zeolite nanoparticles in more details could shed light of their safe applications in medicine. Thus, we probed the molecular interactions between fibrinogen and zeolite nanoparticles using both experimental and simulation approaches. The results indicated that fibrinogen has a strong and thermodynamically favorable interaction with zeolite nanoparticles in a non-cooperative manner. Additionally, fibrinogen experienced a substantial conformational change in the presence of zeolite nanoparticles through a concentration-dependent manner. Simulation results showed that both E- and D-domain of fibrinogen are bound to the EMT zeolite NPs via strong electrostatic interactions, and undergo structural changes leading to exposing normally buried sequences. D-domain has more contribution in this interaction and the C-terminus of γ chain (γ377-394), located in D-domain, showed the highest level of exposure compared to other sequences/residues.