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Assessment of transboundary macro-litter on the remote island of Andaman and Nicobar: Unveiling the governing factors and risk assessment

Shankar VS, De K, Mandal S, Jacob S, Satyakeerthy TR

Mar Pollut Bull, 2024 Dec;209(Pt A):117145.
PMID: 39461182 DOI: 10.1016/j.marpolbul.2024.117145

The increasing occurrence of mismanaged plastic litter along India's coastline and the ominous challenges it poses to biodiversity and ecosystem health is a growing environmental concern. To address this issue, we comprehensively investigated the abundance, composition, and probable sources of marine litter on North Cinque Island, a remote uninhabited island in the Andaman and Nicobar archipelago, Bay of Bengal. This island is a designated wildlife sanctuary and serves as an important nesting site for Green, Hawksbill and Leatherback turtles. A total of 6227 litter items were enumerated, with an average concentration of 0.12 items/m2, representing 20 diverse litter types, with plastic dominating the litter composition (86 %). The cleanliness and environmental hazards of the coast due to the litter were assessed using different indices such as the Clean Coast Index (CCI), Plastic Accumulation Index (PAI), Hazardous Item Index (HII), and Clean Environment Index (CEI). CCI indicates the moderately clean-to-clean status of the surveyed sites. PAI points to low to moderate accumulation of plastic litter. HII of all five coasts fell in category II, suggesting a moderate abundance of hazardous items that can inflict injuries to the foraging turtle and their hatchlings. The CEI articulates the moderately clean to very clean status of the sites. Litter brand audit suggests a considerable amount of stranded litter on the coasts was transboundary and originated from six Indian Ocean Rim Countries (IORC), namely Thailand, Myanmar, Malaysia, Indonesia, Sri Lanka, and UAE. Joint solid waste management by the IORC is the need of the hour to avert litter accumulation on the pristine, remote islands.
Fulltext Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India

Das S, Kar A, Manna S, Mandal S, Mandal S, Das S, et al.

Sci Rep, 2021 05 11;11(1):9946.
PMID: 33976269 DOI: 10.1038/s41598-021-89295-0

Artemisinin is the frontline fast-acting anti-malarial against P. falciparum. Emergence and spread of resistant parasite in eastern-India poses a threat to national malaria control programs. Therefore, the objective of our study is to evaluate the artesunate-sulfadoxine-pyrimethamine efficacy in Central India. 180 monoclonal P. falciparum-infected patients received standard ASSP therapy during August 2015-January 2017, soon after diagnosis and monitored over next 42-days. Artemisinin-resistance was assessed through in-vivo parasite clearance half-life (PC1/2), ex-vivo ring-stage survivability (RSA), and genome analysis of kelch13 and other candidate gene (pfcrt, pfmdr1, pfatpase 6, pfdhfr and pfdhps). Of 180 P. falciparum positive patients, 9.5% showed increased PC1/2 (> 5.5 h), among them eleven isolates (6.1%) showed reduced sensitivity to RSA. In 4.4% of cases, parasites were not cleared by 72 h and showed prolonged PC1/2(5.6 h) (P
Graphene-like emerging 2D materials: recent progress, challenges and future outlook

Uddin MM, Kabir MH, Ali MA, Hossain MM, Khandaker MU, Mandal S, et al.

RSC Adv, 2023 Nov 07;13(47):33336-33375.
PMID: 37964903 DOI: 10.1039/d3ra04456d

Owing to the unique physical and chemical properties of 2D materials and the great success of graphene in various applications, the scientific community has been influenced to explore a new class of graphene-like 2D materials for next-generation technological applications. Consequently, many alternative layered and non-layered 2D materials, including h-BN, TMDs, and MXenes, have been synthesized recently for applications related to the 4th industrial revolution. In this review, recent progress in state-of-the-art research on 2D materials, including their synthesis routes, characterization and application-oriented properties, has been highlighted. The evolving applications of 2D materials in the areas of electronics, optoelectronics, spintronic devices, sensors, high-performance and transparent electrodes, energy conversion and storage, electromagnetic interference shielding, hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and nanocomposites are discussed. In particular, the state-of-the-art applications, challenges, and outlook of every class of 2D material are also presented as concluding remarks to guide this fast-progressing class of 2D materials beyond graphene for scientific research into next-generation materials.
Aetiology, practice patterns and burden of end-stage kidney disease in South Asia and South-East Asia: A questionnaire-based survey

Sahay M, Jasuja S, Tang SCW, Alexander S, Jha V, Vachharajani T, et al.

Nephrology (Carlton), 2021 Feb;26(2):142-152.
PMID: 33169890 DOI: 10.1111/nep.13825

AIM: There is paucity of data on the epidemiology of end-stage kidney disease (ESKD) from South Asia and South-East Asia. The objective of this study was to assess the aetiology, practice patterns and disease burden and growth of ESKD in the region comparing the economies.
METHODS: The national nephrology societies of the region; responded to the questionnaire; based on latest registries, acceptable community-based studies and society perceptions. The countries in the region were classified into Group 1 (High|higher-middle-income) and Group 2 (lower|lowermiddle income). Student t-test, Mann-Whitney U test and Fisher's exact test were used for comparison.
RESULTS: Fifteen countries provided the data. The average incidence of ESKD was estimated at 226.7 per million population (pmp), (Group 1 vs. Group 2, 305.8 vs. 167.8 pmp) and average prevalence at 940.8 pmp (Group 1 vs. Group 2, 1306 vs. 321 pmp). Group 1 countries had a higher incidence and prevalence of ESKD. Diabetes, hypertension and chronic glomerulonephritis were most common causes. The mean age in Group 2 was lower by a decade (Group 1 vs. Group 2-59.45 vs 47.7 years).
CONCLUSION: Haemodialysis was the most common kidney replacement therapy in both groups and conservative management of ESKD was the second commonest available treatment option within Group 2. The disease burden was expected to grow >20% in 50% of Group 1 countries and 78% of Group 2 countries along with the parallel growth in haemodialysis and peritoneal dialysis.