METHOD: A cross-sectional design was employed approximately three months after a major military escalation. A stratified proportional sample of 343 Iranian mothers (aged 24 years and older) with at least one child aged 5-10 years living in conflict-affected areas completed validated self-report measures. Data were analyzed using partial least squares structural equation modeling (PLS-SEM).
RESULTS: The extends model explained substantial variance in maternal anxiety (R ² = .80) and child anxiety (R ² = .72). War-related stressors were significantly and positively associated with both maternal anxiety and child anxiety. In addition, maternal anxiety was significantly associated with child anxiety. Challenge appraisal, problem-focused coping, and cognitive restructuring mediated the relationship between war-related stressors and maternal anxiety. Emotion-focused coping positively mediated the relationship between war-related stressors and child anxiety. Religiosity and social support were found to buffer the association between war-related stressors and maternal anxiety, such that higher levels of religiosity and social support weakened the positive relationship between war-related stressors and anxiety among mothers.
CONCLUSIONS: This study extends the transactional model of stress and coping by supporting an integrated framework within a conflict-affected Middle Eastern population. The findings indicate distinct pathways linking war-related stressors to maternal and child anxiety and highlight the importance of interventions that address cognitive appraisal, strengthen adaptive coping strategies, and mobilize spiritual and social resources in conflict-affected families.
METHODS: We performed a cross-sectional study of IBD demographics, disease phenotype, and treatment across 38 centers in 15 countries of South Asia, South-East Asia, and Middle East. Intergroup comparisons included gross national income (GNI) per capita.
RESULTS: Among 10 400 patients, ulcerative colitis (UC) was twice as common as Crohn's disease (CD), with a male predominance (UC 6678, CD 3495, IBD unclassified 227, and 58% male). Peak age of onset was in the third decade, with a low proportion of elderly-onset IBD (5% age > 60). Familial IBD was rare (5%). The extent of UC was predominantly distal (proctitis/left sided 67%), with most being treated with mesalamine (94%), steroids (54%), or immunomodulators (31%). Ileocolic CD (43%) was the commonest, with low rates of perianal disease (8%) and only 6% smokers. Diagnostic delay for CD was common (median 12 months; interquartile range 5-30). Treatment of CD included mesalamine, steroids, and immunomodulators (61%, 51%, and 56%, respectively), but a fifth received empirical antitubercular therapy. Treatment with biologics was uncommon (4% UC and 13% CD), which increased in countries with higher GNI per capita. Surgery rates were 0.1 (UC) and 2 (CD) per 100 patients per year.
CONCLUSIONS: The IBD-ENC cohort provides insight into IBD in South-East Asia and the Middle East, but is not yet population based. UC is twice as common as CD, familial disease is uncommon, and rates of surgery are low. Biologic use correlates with per capita GNI.