MyMedR

Displaying all 3 publications

Abstract:

Sort:

Fulltext Good anatomical outcome of orbital plasmacytoma following chemo-radiotherapy

Aimy Mastura, Z. Y., Othmaliza, O., Khairunisa, A. A., Norshamsiah, M. D.

Medicine & Health, 2017;12(2):341-347.
MyJurnal

Plasmasitoma ekstramedulari adalah komplikasi myeloma berbilang yang sangat
jarang berlaku. Kami melaporkan kes seorang wanita berumur 56 tahun yang
menghidap myeloma berbilang yang telah mengalami bengkak pada mata kiri. Ia
menyebabkan bola mata beliau tersembul, luka pada kornea dan juga kemerosotan
penglihatan. Biopsi tisu menunjukkan perebakan plasma sel neoplastik yang positif
kepada CD138 dan rantai ringan Kappa yang menepati ciri-ciri plasmasitoma.
Setelah melalui rawatan radio-kemoterapi, pembengkakan mata susut dengan
ketara sekali namun kemerosotan penglihatan beliau tidak berubah.
Case series of children with steroid-Induced glaucoma

Lam CS, Umi Kalthum MN, Norshamsiah MD, Bastion M

Malays Fam Physician, 2018;13(3):32-37.
PMID: 30800232

Steroid-induced glaucoma is the most serious complication of the injudicious use of steroids, particularly among children affected by allergic conjunctivitis. This condition is steroid-dependent, and children are commonly being prescribed topical anti-inflammatories, including topical steroids, by general practitioners. Furthermore, topical steroids are also available over the counter, and this availability contributes to overuse without proper monitoring by an ophthalmologist. We present a series of five cases illustrating the devastating effect of unmonitored, long-term use of steroids among children for vernal keratoconjunctivitis. The medications were prescribed initially by general ophthalmologists and were continually bought over the counter by parents. At the presentation to our center, these patients were already compromised visually, exhibiting glaucomatous optic disc changes and high intraocular pressure. The series highlights the optic nerve damage resulting in irreversible visual compromises among children on long-term, topical steroids and the importance of regular monitoring with a low threshold for ophthalmologist referral.
Randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease

Atikah A, Suzana M, Wan Haslina WAH, Norshamsiah MD, Mushawiahti M, Birinder KSS, et al.

Cont Lens Anterior Eye, 2024 Dec 15.
PMID: 39676005 DOI: 10.1016/j.clae.2024.102346

PURPOSE: To assess the short-term effects of topical insulin (TI) as compared to topical Systane UltraTM (Alcon, USA) as artificial tears (AT) and topical normal saline (NS) on tear inflammatory mediators; interleukin 1-alpha (IL-1a), interleukin 6 (IL-6) and matrix metalloproteinase 9 (MMP-9) and clinical dry eye parameters in diabetics with dry eye disease (DDED).
METHODS: In this randomized, multi-arm parallel single-centre trial, 73 diabetics with dry eye disease (30 female and 43 male) aged 18 to 50 years were recruited. They were randomly assigned to four weeks of treatment of either TI 0.5 unit/drop, AT or NS four times per day. Tear sample analysis and clinical parameters of dry eye (Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), corneal Oxford score and Schirmers test) were evaluated at baseline and four weeks later. Objective clinical parameters for corneal Oxford score and tear break-up time were assessed by two masked investigators.
RESULTS: Significant reduction was seen in all inflammatory biomarkers (IL-1a, IL-6 and MMP-9) in all treatment groups at 4 weeks. In addition, inflammatory biomarkers demonstrated a significant reduction with TI (p

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links