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  1. Fatema KN, Jung CH, Liu Y, Sagadevan S, Cho KY, Oh WC
    ACS Biomater Sci Eng, 2020 12 14;6(12):6981-6994.
    PMID: 33320627 DOI: 10.1021/acsbiomaterials.0c00423
    In the present study, electrochemical sensing for urea was proposed utilizing graphene-based quaternary nanocomposites YInWO4-G-SiO2 (YIWGS). These YIWGS nanocomposites were utilized due to their exceptionally delicate determination of urea with the lowest detection limit (0.01 mM). These YIWGS composites were developed through a simple self-assembly method. From physical characterization, we found that the YIWGS composites are crystalline in nature (powdered X-ray diffraction), and Fourier transform infrared (FTIR) spectroscopy analysis provided the surface functionality and bonding. Scanning electron microscopy (SEM) studies indicated the morphology characteristics of the as-synthesized composites and the high-resolution transmission electron microscopy (HRTEM) image supported the formation of cubic or hexagonal morphology of the YIW nanocomposites. The YIWGS sensor showed a great electroanalytical sensing performance of 0.07 mM urea with a sensitivity of 0.06 mA cm-2, an expansive linear range of 0.7-1.5 mM with a linear response (R2 1/4 0.99), and an eminent reaction time of around 2 s. It also displayed a good linear response toward urea with negligible interferences from normal coinciding species in urine samples.
  2. Fatimah I, Purwiandono G, Hidayat H, Sagadevan S, Ghazali SAISM, Oh WC, et al.
    Nanomaterials (Basel), 2021 Nov 10;11(11).
    PMID: 34835776 DOI: 10.3390/nano11113012
    The present study reported biofabrication of flower-like SnO2 nanoparticles using Pometia pinnata leaf extract. The study focused on the physicochemical characteristics of the prepared SnO2 nanoparticles and its activity as photocatalyst and antibacterial agent. The characterization was performed by XRD, SEM, TEM, UV-DRS and XPS analyses. Photocatalytic activity of the nanoparticles was examined on bromophenol blue photooxidation; meanwhile, the antibacterial activity was evaluated against Klebsiella pneumoniae, Escherichia coli Staphylococcus aureus and Streptococcus pyogenes. XRD and XPS analyses confirmed the single tetragonal SnO2 phase. The result from SEM analysis indicates the flower like morphology of SnO2 nanoparticles, and by TEM analysis, the nanoparticles were seen to be in uniform spherical shapes with a diameter ranging from 8 to 20 nm. SnO2 nanoparticles showed significant photocatalytic activity in photooxidation of bromophenol blue as the degradation efficiency reached 99.93%, and the photocatalyst exhibited the reusability as the degradation efficiency values were insignificantly changed until the fifth cycle. Antibacterial assay indicated that the synthesized SnO2 nanoparticles exhibit an inhibition of tested bacteria and showed a potential to be applied for further environmental and medical applications.
  3. Muthu BR, Pushpa EP, Dhandapani V, Jayaraman K, Vasanthakumar H, Oh WC, et al.
    Sensors (Basel), 2021 Dec 22;22(1).
    PMID: 35009576 DOI: 10.3390/s22010033
    Aerospace equipages encounter potential radiation footprints through which soft errors occur in the memories onboard. Hence, robustness against radiation with reliability in memory cells is a crucial factor in aerospace electronic systems. This work proposes a novel Carbon nanotube field-effect transistor (CNTFET) in designing a robust memory cell to overcome these soft errors. Further, a petite driver circuit to test the SRAM cells which serve the purpose of precharge and sense amplifier, and has a reduction in threefold of transistor count is recommended. Additionally, analysis of robustness against radiation in varying memory cells is carried out using standard GPDK 90 nm, GPDK 45 nm, and 14 nm CNTFET. The reliability of memory cells depends on the critical charge of a device, and it is tested by striking an equivalent current charge of the cosmic ray's linear energy transfer (LET) level. Also, the robustness of the memory cell is tested against the variation in process, voltage and temperature. Though CNTFET surges with high power consumption, it exhibits better noise margin and depleted access time. GPDK 45 nm has an average of 40% increase in SNM and 93% reduction of power compared to the 14 nm CNTFET with 96% of surge in write access time. Thus, the conventional MOSFET's 45 nm node outperforms all the configurations in terms of static noise margin, power, and read delay which swaps with increased write access time.
  4. Oh WC, Fatema KN, Liu Y, Jung CH, Sagadevan S, Biswas MRUD
    ACS Omega, 2020 Jul 21;5(28):17337-17346.
    PMID: 32715218 DOI: 10.1021/acsomega.0c01699
    In this study, we demonstrate the fabrication and characterization of a new quaternary semiconductor nanocomposite of LiCuMo2O11/graphene oxide/polypyrrole (LCMGP) via a hydrothermal method and testing of an NH3 and H2SO4 sensor operating in gaseous states at room temperature. We used X-ray diffraction, transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy to characterize the properties of LCMGP nanostructures. Our sensor is capable of detecting NH3 and H2SO4 and quantifying their concentration in the gas flow. These results have been confirmed by exposing the sensor to different concentrations of NH3 and H2SO4 (100-1000 ppm). The obtained results confirm the exceptional sensing properties of the graphene-polymer-combined quaternary semiconductor nanocomposite related to the oxidation-reduction process that can be used for detection, identification, and quantification purposes.
  5. Sathiyanarayanan V, Prasath PV, Sekhar PC, Ravichandran K, Easwaramoorthy D, Mohammad F, et al.
    RSC Adv, 2020 Apr 23;10(28):16457-16472.
    PMID: 35692617 DOI: 10.1039/d0ra01936d
    A new series of lanthanum(iii) complexes was synthesized using a p-anisidine-appended 1-hydroxy-2-acetonapthanone (3) Schiff base and characterized via spectroscopic methods. The ligand was synthesized via sonication and the crystalline product was characterized using X-ray crystallography. The genotoxicity of the compound was assessed primarily by the bacterial reverse mutation (Ames) test and the in vitro mammalian chromosome aberration test; in both cases, the samarium complex 5 was found to be non-mutagenic. The anti-tumor activity of complexes 4, 5, and 6 was assayed against HeLa tumor cells and screened using the MTT assay. The IC50 value of complex 5 was found to be 34 ± 1.2 μg mL-1 and this compound exhibited superior activity towards the cells compared to 4 and 6. These results were further confirmed by Hoechst 33258 staining and AO/EI dual staining, which indicated that the cells underwent an apoptosis mechanism in a dose-dependent manner. The apoptosis was further confirmed by the formation of ladders in the DNA fragmentation assay, and the western blot analysis of complex 5 suggested that the cells underwent the caspase-3-dependent pathway with PARP cleavage. Furthermore, the docking studies of complex 5 with HSA showed that it was situated in a hydrophilic cavity held by the electrostatic attraction of four hydrogen-bonding interactions. PDB ID:1BNA binds with complex 5via strong π-π stacking interactions, which facilitate binding with the major grooves of DNA strands. The above-mentioned results illustrate that for complex 5, mitochondrion-mediated apoptosis occurs via caspase-3 activation. Complex 5 binds with DNA via intercalation because of S-phase cell cycle arrest in the HeLa cells.
  6. Abubakar S, Tan ST, Liew JYC, Talib ZA, Sivasubramanian R, Vaithilingam CA, et al.
    Nanomaterials (Basel), 2023 Mar 13;13(6).
    PMID: 36985919 DOI: 10.3390/nano13061025
    Zinc oxide (ZnO) nanorods have attracted considerable attention in recent years owing to their piezoelectric properties and potential applications in energy harvesting, sensing, and nanogenerators. Piezoelectric energy harvesting-based nanogenerators have emerged as promising new devices capable of converting mechanical energy into electric energy via nanoscale characterizations such as piezoresponse force microscopy (PFM). This technique was used to study the piezoresponse generated when an electric field was applied to the nanorods using a PFM probe. However, this work focuses on intensive studies that have been reported on the synthesis of ZnO nanostructures with controlled morphologies and their subsequent influence on piezoelectric nanogenerators. It is important to note that the diatomic nature of zinc oxide as a potential solid semiconductor and its electromechanical influence are the two main phenomena that drive the mechanism of any piezoelectric device. The results of our findings confirm that the performance of piezoelectric devices can be significantly improved by controlling the morphology and initial growth conditions of ZnO nanorods, particularly in terms of the magnitude of the piezoelectric coefficient factor (d33). Moreover, from this review, a proposed facile synthesis of ZnO nanorods, suitably produced to improve coupling and switchable polarization in piezoelectric devices, has been reported.
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