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  1. Polyphenols rich fraction of Dicranopteris linearis promotes fibroblast cell migration and proliferation in vitro
    Ponnusamy Y, Chear NJ, Ramanathan S, Lai CS
    J Ethnopharmacol, 2015 Jun 20;168:305-14.
    PMID: 25858509 DOI: 10.1016/j.jep.2015.03.062
    Dicranopteris linearis is a fern used traditionally for the treatment of skin afflictions such as external wounds, boils and ulcers. However, there are no scientific studies to date to demonstrate its ability to induce wound recovery. The objective of the present study was to explore the wound healing properties of an active fraction of D. linearis through several in vitro assays and to determine its chemical profile.
  2. The potentiation of beta-lactam and anti-bacterial activities of lipophilic constituents from Mesua ferrae leaves against methicillin-resistant Staphylococcus aureus
    Alagasamy SV, Ramanathan S, Chear NJ, Tan WN, Ramachandram DS, Ching-Ga AT, et al.
    J Complement Integr Med, 2021 Jan 01;18(2):339-345.
    PMID: 34187118 DOI: 10.1515/jcim-2019-0316
    OBJECTIVES: Mesua ferrae, from the family of Calophyllaceae, is traditionally used for the treatment of piles, fever and renal disorders. The present study was aimed to examine the antibacterial compounds from the leaves of M. ferrae and their β-lactam antibiotic potentiate activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).

    METHODS: Stigmasterol (1) and β-caryophyllene oxide (2) were isolated from the n-hexane fraction of the leaves of M. ferrae using a bioassay-guided fractionation approach.

    RESULTS: The isolated compounds displayed anti-Staphylococcus and anti-MRSA activities. It is worth to note that both compounds demonstrated synergism with β-lactam antibiotics against S. aureus and MRSA. Gas chromatography-mass spectrometry (GC-MS) analysis indicated the n-hexane fraction was dominated by triterpenes and sesquiterpenes, suggesting the total antibacterial activity exhibited by the fraction.

    CONCLUSION: Based on the findings, it could conclude that M. ferrae is a promising natural source for the discovery of new anti-MRSA lead compounds.

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