Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 with IC50 values ranging from 160.74 to 299.75 μM.
New seco-apotirucallane triterpenoids, pachyphylinin A (1) and B (2), were isolated from the stem bark of Aglaia pachyphylla alongside nine triterpenoid compounds (3-11). The structures were elucidated and identified through various spectroscopic analyses, including 1D and 2D NMR, HRTOF-MS, FTIR, as well as ECD, complemented by computational calculation using TD-DFT. In the process, pachyphylinin A (1) and B (2) were tested for cytotoxic activity against the breast cancer cell line (MCF-7). The results showed cytotoxic activities against MCF-7 with IC50 values in the range of 98.8-500 µM.