Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity

Safriansyah W 1 , Juliansyah E 1 , Rustaman 1 , Naini AA 1 , Farabi K 1 , Azmi MN 2 Show all authors , Nafiah MA 3 , Kuncoro H 4 , Supratman U 1 , Fajriah S 5 , Harneti D 1

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
  • 2 School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang 1180, Malaysia
  • 3 Department of Chemistry, Faculty of Sciences and Mathematic, Sultan Idris Education University, Tg Malim, Perak 35900, Malaysia
  • 4 Faculty of Pharmacy, Mulawarman University, Samarinda 75119, Indonesia
  • 5 Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK, Serpong, Tangerang Selatan 15314, Indonesia
J Asian Nat Prod Res, 2025 Jan 10.
PMID: 39791902 DOI: 10.1080/10286020.2024.2446280

Abstract

Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 with IC50 values ranging from 160.74 to 299.75 μM.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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