Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae)

Katja DG 1 , Hilmayanti E 2 , Nurlelasari 2 , Mayanti T 2 , Harneti D 2 , Maharani R 2 Show all authors , Farabi K 2 , Darwati 2 , Lesmana R 3 , Fajriah S 4 , Supratman U 2 , Azmi MN 5 , Shiono Y 6

Affiliations 

  • 1 Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia
  • 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, West Java, Indonesia
  • 3 Central Laboratory of Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia
  • 4 Research Center for Chemistry, Indonesian Science Institute, Serpong 15311, South Tangerang, Indonesia
  • 5 School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang 11800, Malaysia
  • 6 Department of Bioresources Engineering, Faculty of Agriculture Yamagata University, Tsuruoka-shi, Yamagata 997-8555, Japan
J Asian Nat Prod Res, 2023 Jan;25(1):36-43.
PMID: 35128999 DOI: 10.1080/10286020.2022.2032678

Abstract

Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3-5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC50 value of 43.38 μM.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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