A new limonoid from stem bark of Chisocheton pentandrus (Meliaceae)

Supriatno; Nurlelasari; Herlina T; Harneti D; Maharani R; Hidayat AT; Mayanti T; Supratman U; Azmi MN; Shiono Y

doi:10.1080/14786419.2018.1428600

A new limonoid from stem bark of Chisocheton pentandrus (Meliaceae)

Supriatno ¹ , Nurlelasari ¹ , Herlina T ¹ , Harneti D ¹ , Maharani R ¹ , Hidayat AT ¹ Show all authors , Mayanti T ¹ , Supratman U ¹ , Azmi MN ² , Shiono Y ³

Affiliations

¹ a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor , Indonesia
² c School of Chemical Sciences , Universiti Sains Malaysia , Minden , Malaysia
³ d Faculty of Agriculture, Department of Food, Life and Environmental Science , Yamagata University , Tsuruoka , Japan

Nat Prod Res, 2018 Nov;32(21):2610-2616.

PMID: 29368952 DOI: 10.1080/14786419.2018.1428600

Abstract

A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures of the new compound were elucidated on the basis of spectroscopic evidence. All of the compounds were tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1-4 showed weak and no cytotoxicity against MCF-7 breast cancer cells with IC50 values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.