New dammarane-type triterpenoids from Aglaia elliptica (C.DC.) blume

Farabi K 1 , Harneti D 1 , Darwati 1 , Nurlelasari 1 , Mayanti T 1 , Maharani R 1 Show all authors , Supratman U 1 , Fajriah S 2 , Kuncoro H 3 , Azmi MN 4 , Shiono Y 5

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, West Java, Indonesia
  • 2 Research Center for Raw Materials for Medicine and Traditional Medicine, National Research and Innovation Agency (BRIN), Tangerang Selatan, Banten, Indonesia
  • 3 Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
  • 4 School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
  • 5 Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan
Nat Prod Res, 2024;38(2):227-235.
PMID: 35994369 DOI: 10.1080/14786419.2022.2114472

Abstract

Three new dammarane-type triterpenoids, namely elliptaglin A-C (1-3) were isolated from the stem bark of Aglaia elliptica (C.DC.) Blume along with three known derivatives, namely (20S)-hydroxydammar-24-en-3-on (4), cabralealactone (5), and E-25-hydroperoxydammar-23-en-20-ol-3-one (6). Subsequently, their chemical structures were determined using HR-ESI-MS, FTIR, 1D and 2D-NMR spectroscopic analysis as well as comparison with previous studies. The cytotoxicity activities of the isolated compounds against MCF-7 breast cancer and B16-F10 melanoma cell lines were then tested using PrestoBlue reagent. The analysis results showed that elliptaglin B (2) had the strongest activity against both cell lines with IC50 values of 60.98 and 51.83 µM, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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