Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss

Riyadi SA 1 , Naini AA 1 , Mayanti T 2 , Lesmana R 2 , Azmi MN 3 , Fajriah S 4 Show all authors , Jungsuttiwong S 5 , Supratman U 6

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
  • 2 Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
  • 3 School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800, Penang, Malaysia
  • 4 Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK Serpong Tangerang, Selatan, 15314, Indonesia
  • 5 Department of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand
  • 6 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia. unang.supratman@unpad.ac.id
J Nat Med, 2024 Mar 22.
PMID: 38517622 DOI: 10.1007/s11418-024-01794-2

Abstract

A total of five new mexicanolides (1-5), namely alliaxylines A-E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC50 values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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