Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae)

Katja DG 1 , Farabi K 1 , Nurlelasari 1 , Harneti D 1 , Mayanti T 1 , Supratman U 1 Show all authors , Awang K 2 , Hayashi H 3

Affiliations 

  • 1 a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia
  • 2 c Faculty of Science, Department of Chemistry , University of Malaya , Kuala Lumpur 59100 , Malaysia
  • 3 d Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences , Osaka Prefecture University , Osaka 599-8531 , Japan
J Asian Nat Prod Res, 2016 Jun 22.
PMID: 27329305 DOI: 10.1080/10286020.2016.1196671

Abstract

A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost-9(11),24(24')-diene (1), along with 3β-hydroxy-lanost-7-ene (2) and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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