Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells

Nurlelasari 1 , Parulian SS 1 , Naini AA 1 , Hilmayanti E 1 , Farabi K 1 , Harneti D 1 Show all authors , Darwati 1 , Mayanti T 1 , Maharani R 1 , Herlina T 1 , Supratman U 1 , Anwar R 2 , Fajriah S 3 , Azmi MN 4 , Prescott T 5 , Shiono Y 6

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
  • 2 Herbal Medicine Research, Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang 50272, Indonesia
  • 3 Research Center for Chemistry, National Research and Innovation Agency (BRIN) Kawasan PUSPIPTEK Serpong Tangeran Selatan, Banten 15314, Indonesia
  • 4 School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia
  • 5 Royal Botanic Gardens, Kew, Richmond TW9 3AB, United Kingdom
  • 6 Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka 997-8555, Japan
J Asian Nat Prod Res, 2023;25(8):803-809.
PMID: 36409205 DOI: 10.1080/10286020.2022.2143353

Abstract

Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures of compounds 1-3 were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound 1 showed the most potent activity (IC50 26.56 ± 1.01 µM) and was two-fold more active than the positive control.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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