A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp

Murtihapsari M 1 , Salam S 1 , Kurnia D 1 , Darwati D 1 , Kadarusman K 2 , Abdullah FF 3 Show all authors , Herlina T 1 , Husna MH 4 , Awang K 4 , Shiono Y 5 , Azmi MN 6 , Supratman U 1

Affiliations 

  • 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia
  • 2 Department of Aquatic Resources Management, Fisheries Higher School, KKD PSP, SRBE, Jakarta, Indonesia
  • 3 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, Indonesia
  • 4 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 5 Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, Japan
  • 6 School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
Nat Prod Res, 2021 Mar;35(6):937-944.
PMID: 31210054 DOI: 10.1080/14786419.2019.1611815

Abstract

A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 and 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds 1 and 2 exhibited antiplasmodial activity with IC50 values of 359 and 0.250 nM, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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