Pachyphylinin A-B: two novel seco-apotirucallane triterpenoids with cytotoxic activities from the stem bark of Aglaia pachyphylla

Safriansyah W 1 , Hilmayanti E 2 , Rustaman 3 , Farabi K 3 , Nafiah MA 4 , Azmi MN 5 Show all authors , Fajriah S 6 , Kabayama K 2 , Shimoyama A 2 , Manabe Y 2 , Fukase K 2 , Kuncoro H 7 , Supratman U 3 , Harneti D 8

Affiliations 

  • 1 Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Jalan Raya Bogor Km. 46, Cibinong, Bogor, 16911, Indonesia
  • 2 Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, 560-0043, Japan
  • 3 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia
  • 4 Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education University, Tanjung Malim, 35900, Perak, Malaysia
  • 5 School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang, 11800, Malaysia
  • 6 Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK, Serpong, Tangerang Selatan, 15314, Indonesia
  • 7 Faculty of Pharmacy, Mulawarman University, Samarinda, 75119, Indonesia
  • 8 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia. desi.harneti@unpad.ac.id
J Nat Med, 2026 Jan;80(1):199-206.
PMID: 41444468 DOI: 10.1007/s11418-025-01976-6

Abstract

New seco-apotirucallane triterpenoids, pachyphylinin A (1) and B (2), were isolated from the stem bark of Aglaia pachyphylla alongside nine triterpenoid compounds (3-11). The structures were elucidated and identified through various spectroscopic analyses, including 1D and 2D NMR, HRTOF-MS, FTIR, as well as ECD, complemented by computational calculation using TD-DFT. In the process, pachyphylinin A (1) and B (2) were tested for cytotoxic activity against the breast cancer cell line (MCF-7). The results showed cytotoxic activities against MCF-7 with IC50 values in the range of 98.8-500 µM.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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