Displaying all 3 publications

Abstract:
Sort:
  1. Nugraha MW, Zainal Abidin NH, Supandi, Sambudi NS
    Chemosphere, 2021 Aug;277:130300.
    PMID: 33774232 DOI: 10.1016/j.chemosphere.2021.130300
    In this present study, the tungsten oxide/amino-functionalized sugarcane bagasse derived-carbon quantum dots (WO3/N-CQDs) composite has successfully been prepared through a simple mixing process. The WO3 was synthesized through a precipitation method, and CQDs were amino-functionalized using ethylenedinitrilotetraacetic acid (EDTA) and ethylenediamine (EDA) through one-pot hydrothermal method. It is revealed that N-CQDs incorporation into WO3 alters the bandgap energy, crystallinity, surface area, and photoluminescence (PL) properties. The produced composites exhibit higher monoclinic WO3 crystallinity, larger surface area, lower bandgap energy and quenched photoluminescence intensity. The as-prepared WO3/N-CQDs composites exhibit better adsorption and photocatalytic degradation performance of methylene blue (MB) than the pristine WO3. It shows that the combination of N-CQDs and WO3 enhanced visible light absorption, by lowering the bandgap energy of WO3 from 2.175 to 1.495 eV. The best performance composite is WO3/N-CQDs EDA 2.5% with an efficiency of 96.86%, removal rate constant of 0.02017/min, and chemical oxidation demand (COD) removal efficiency achieved 84.61%. Moreover, the WO3/N-CQDs EDA 2.5% shows a significant photocatalytic activity even at higher MB initial concentration with 92.93% removal for 50 ppm MB. Subsequently, the composite also has good stability after a sequential 3-times cycle of degradation with 86.85% removal. The increasing photocatalytic performance is affected by the quenching effect of PL and lower bandgap energy. The lower intensity of the PL indicates the reduced charge carrier recombination resulting in increased photocatalytic activity. The combination of N-CQDs and WO3 resulted in improved photodegradation, which shows its significant potential to be utilized for wastewater treatment.
  2. Ibrahim NN, Mohd Noor N, Bahari R, Mohamed Nor L, Zainal Abidin NH
    Malays J Med Sci, 2024 Apr;31(2):199-207.
    PMID: 38694585 DOI: 10.21315/mjms2024.31.2.18
    BACKGROUND: Inpatient hyperglycaemia is common and associated with poor outcomes such as increased mortality and prolonged hospital stay. This study aimed to determine the prevalence of inpatient hyperglycaemia and glycaemic control in Putrajaya Hospital, Malaysia. Secondary objectives were to compare the length of stay (LOS), 30-day readmission rate, and death between controlled and uncontrolled glycaemic groups.

    METHODS: This cross-sectional study was conducted between 1 July and 31 December 2019 among patients in medical wards who had a blood glucose (BG) level of > 7.8 mmol/L and stayed in the wards for ≥ 24 h. We retrieved information on demographics, diabetes history and BG profiles. The definition of controlled glycaemic status is when ≥ 80% of BG readings were between 4.0 mmol/L and 10.0 mmol/L during the hospital stay.

    RESULTS: The prevalence of inpatient hyperglycaemia was 55.2%. There were 841 patients who met the eligibility criteria; their mean age was 60 (13.8) years old. Most (79.4%) of the patients were Malay and 53.9% were male. There were 452 (53.7%) patients in the uncontrolled group. They were younger and admitted with more kidney complications compared to those in the controlled group. The median LOS for both groups was 3 (2) days. The uncontrolled group showed a higher percentage of readmission within 30 days (7.5% versus 4.6 %) and death during admission (3.3% versus 1.6 %) (P = 0.100 and P = 0.082).

    CONCLUSION: The prevalence of inpatient hyperglycaemia was high. More than half of them had uncontrolled BG. Both groups had a similar average length of stay. The 30-day readmission rate and death during admission were higher in the uncontrolled group, although statistically not significant.

  3. Mohamad Razif MI, Nizar N, Zainal Abidin NH, Muhammad Ali SN, Wan Zarimi WNN, Khotib J, et al.
    Expert Rev Vaccines, 2023;22(1):629-642.
    PMID: 37401128 DOI: 10.1080/14760584.2023.2232450
    INTRODUCTION: mRNA vaccines have been developed as a promising cancer management. It is noted that specification of the antigen sequence of the target antigen is necessary for the design and manufacture of an mRNA vaccine.

    AREAS COVERED: The steps involved in preparing the mRNA-based cancer vaccines are isolation of the mRNA cancer from the target protein using the nucleic acid RNA-based vaccine, sequence construction to prepare the DNA template, in vitro transcription for protein translation from DNA into mRNA strand, 5' cap addition and poly(A) tailing to stabilize and protect the mRNA from degradation and purification process to remove contaminants produced during preparation.

    EXPERT OPINION: Lipid nanoparticles, lipid/protamine/mRNA nanoparticles, and cell-penetrating peptides have been used to formulate mRNA vaccine and to ensure vaccine stability and delivery to the target site. Delivery of the vaccine to the target site will trigger adaptive and innate immune responses. Two predominant factors of the development of mRNA-based cancer vaccines are intrinsic influence and external influence. In addition, research relating to the dosage, route of administration, and cancer antigen types have been observed to positively impact the development of mRNA vaccine.

Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links