MyMedR

A case report of severe mycoplasma pneumonia with autoimmune haemolytic anaemia

Roshan S, Tan SW

Med J Malaysia, 2020 09;75(5):600-602.

Mycoplasma pneumonia is a common cause of respiratory disease and more so in school going children. The spectrum of the manifestations range from haematological, dermatological, neurological, musculoskeletal, renal, cardiac and also gastrointestinal. The treatment approach has varied over time. In this report we would like to share our experience in a case of M.pneumonia with autoimmune haemolytic anaemia (AIHA).

Matched MeSH terms: Pneumonia, Mycoplasma/diagnosis; Pneumonia, Mycoplasma/physiopathology*; Pneumonia, Mycoplasma/surgery

Fulltext Isolation of Mycoplasma hyosynoviae from pneumonic lung of swine

Dahlia H, Tan LJ, Zarrahimah Z, Maria J

Trop Biomed, 2009 Dec;26(3):341-5.

PMID: 20237449 MyJurnal

The isolation of Mycoplasma hyosynoviae from a piglet with severe pneumonia is described. This is the first report of M. hyosynoviae isolation in the country. The lung sample where the isolation was made was severely consolidated, suppurative and pleurisy. The pathogenicity of the M. hyosynoviae isolated has yet to be determined.

Matched MeSH terms: Pneumonia, Mycoplasma/diagnosis; Pneumonia, Mycoplasma/microbiology; Pneumonia, Mycoplasma/veterinary*

Fulltext A 'target' skin lesion

Loh KY

Aust Fam Physician, 2008 Nov;37(11):946.

PMID: 19037470

A boy, 12 years of age, was being treated for pneumonia. The cold haemagglutination test was positive for Mycoplasma pneumoniae. He developed an isolated asymptomatic skin lesion on his lower limb which disappeared completely after 1 week.

Matched MeSH terms: Pneumonia, Mycoplasma/diagnosis

The first isolate of Mycoplasma pneumoniae in Malaysia

Cheong YM, Jegathesan M, Singh M, Wong S, Ong L

Malays J Pathol, 1985 Aug;7:51-2.

PMID: 3939616

Matched MeSH terms: Pneumonia, Mycoplasma/diagnosis

Fulltext Mycoplasma pneumoniae infection complicated by empyema: a rare presentation

Othman N, Yip CW, Samat NA

Med J Malaysia, 2005 Aug;60(3):389-91.

PMID: 16379202

Mycoplasma pneumoniae is a common causative agent for childhood pneumonia. However, empyema is a rare presentation. We report a case of a previously well child who presented with a right-sided empyema. M. pneumoniae was confirmed serologically with evidence of a four-fold rise in Mycoplasma IgM titre. The empyema required drainage procedures for more than two weeks. The infection resolved with a course of six weeks of treatment with erythromycin.

Matched MeSH terms: Pneumonia, Mycoplasma/complications*; Pneumonia, Mycoplasma/drug therapy

Prevalence and molecular detection of contagious bovine pleuropneumonia in large ruminants in Punjab, Pakistan

Anjum A, Usman S, Aslam A, Faiz M, Usman S, Imran MS, et al.

Trop Biomed, 2020 Jun 01;37(2):273-281.

PMID: 33612797

Contagious bovine pleuropneumonia (CBPP) is a highly contagious disease of cattle caused by Mycoplasma mycoides subsp. mycoides. It is characterized by anorexia, fever, dyspnea, polypnea, cough, and nasal discharges. Gross lesions in the lung such as marbling, sequestra, thickening of interlobular septa, and consolidation are evident. Serological tests including complement fixation test and competitive enzyme-linked immunosorbent assay and molecular tests such as polymerase chain reactions are used for diagnostic purposes. In this study, lung samples of suspected large ruminants (cattle n=560, buffalo n=293) were collected from abattoirs of three districts of Punjab namely Lahore, Kasur and Jhang. PCR was performed with specific primers, targeting the 16S ribosomal RNA gene to detect the positive cases. The results indicated that 49 samples (8.75%) of cattle were positive, with maximum prevalence was observed in Jhang with 16 positive samples (10.06%), but CBPP was not detected in any buffalo sample. High prevalence of disease was seen in cattle of more than seven years of age, in female cattle, and in cross-bred cattle. Age and gender were found significantly associated (P<0.05) with the prevalence of the disease. Gene sequencing of identified 5 isolates of Mycoplasma mycoides subsp. mycoides had more than 99% similarities with the strains isolated from China, Italy, Australia and Tanzania and were categorized into a monophyletic group but strain isolated from Portugal had more than 55% variable regions, hence clustered separately. This study confirms the presence of contagious bovine pleuropneumonia in the country which can be a threat to the livestock export market and warrants the implementation of control measures to mitigate the economic losses associated with the disease.

Matched MeSH terms: Pneumonia, Mycoplasma/enzymology; Pneumonia, Mycoplasma/veterinary*

Transient parkinsonism following mycoplasma pneumoniae infection with normal brain magnetic resonance imaging (MRI)

Tay CG, Fong CY, Ong LC

J Child Neurol, 2014 Dec;29(12):NP193-5.

PMID: 24309239 DOI: 10.1177/0883073813510741

Parkinsonism caused by infection is uncommon in children. We report 2 previously healthy children with acute self-limiting parkinsonism following Mycoplasma pneumoniae infection, with normal brain magnetic resonance imaging (MRI). Our case report expands the phenotype of parkinsonism associated with M. pneumoniae infection. We recommend that children with acute parkinsonism preceded by a period of febrile illness, even with a normal brain MRI, should be investigated for M. pneumoniae infection.

Matched MeSH terms: Pneumonia, Mycoplasma/complications*

A review of the serological results obtained in a routine diagnostic laboratory for Mycoplasma pneumoniae infections

Tay ST, Cheong YM

Malays J Pathol, 1995 Jun;17(1):35-7.

PMID: 8907003

The results of a Mycoplasma pneumoniae serology test performed routinely at the Bacteriology Division, Institute for Medical Research were reviewed. A total of 1402 patients were screened over a period of 4 years (January, 1990-December, 1993), of which 327 (23.3%) were seropositive. The seropositivity rates among Malays, Chinese and Indians were 25.2, 25.4 and 17.8% respectively. The male to female ratio was 1:1. The age specific rate was highest amongst patients of the 6-12 years (35.1%) followed by the 13-20 years age groups (35.0%). In general, infection with M. pneumoniae appears to be relatively common in this country.

Matched MeSH terms: Pneumonia, Mycoplasma/diagnosis*; Pneumonia, Mycoplasma/ethnology

Ameliorative effect of Albizia chinensis synthesized ZnO-NPs on Mycoplasma pneumoniae infected pneumonia mice model

Yu L, Lu M, Zhang W, Alarfaj AA, Hirad AH, Zhang H

Microb Pathog, 2020 Apr;141:103960.

PMID: 31953224 DOI: 10.1016/j.micpath.2019.103960

BACKGROUND: Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia (CAP) among the children and adults that results upper and lower respiratory tract infections.

OBJECTIVE: This study was aimed to inspect the ameliorative action of A. chinensis synthesized ZnONPs against M. pneumoniae infected pneumonia mice model.

MATERIALS AND METHODS: ZnO NPs was synthesized from Albizia chinensis bark extract and characterized by UV-Vis spectroscopy, Fourier Transform Infrared (FTIR), Transmission Electron Microscopy (TEM), energy dispersive X-ray (EDX) and atomic force microscope (AFM) analyses. The antibacterial effectual of synthesized ZnONPs were examined against clinical pathogens. The pneumonia was induced to BALB/c mice via injecting the M. pneumoniae and treated with synthesized ZnONPs, followed by the total protein content, total cell counts and inflammatory mediators level was assessed in the BALF of experimental animals. The Histopathological investigation was done in the lung tissues of test animals.

RESULTS: The outcomes of this work revealed that the formulated ZnONPs was quasi-spherical, radial and cylindrical; the size was identified as 116.5 ± 27.45 nm in diameter. The in vitro antimicrobial potential of formulated ZnO-NPs displayed noticeable inhibitory capacity against the tested fungal and bacterial strains. The administration of synthesized ZnO-NPs in MP infected mice model has significantly reduced the levels of total protein, inflammatory cells, inflammatory cytokines such as IL-1, IL-6, IL-8, tumour necrosis factor-alpha (TNF-a) and transforming growth factor (TGF). Besides, the histopathological examination of MP infected mice lung tissue showed the cellular arrangements were effectively retained after administration of synthesized ZnO-NPs.

CONCLUSION: In conclusion, synthesized ZnO-NPs alleviate pneumonia progression via reducing the level of inflammatory cytokines and inflammatory cells in MP infected mice model.

Matched MeSH terms: Pneumonia, Mycoplasma/microbiology; Pneumonia, Mycoplasma/pathology

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