Displaying publications 21 - 40 of 159 in total

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  1. The quality of life among coronary heart disease patients at a teaching hospital
    Ho SE, Ting CK, Das S, Loo CY, Rohayu AB, Khor SY, et al.
    Clin Ter, 2011;162(3):217-22.
    PMID: 21717045
    Quality of life after acute coronary heart disease amongst patients is important outcome factor in deliberations of patient's care. The main aim of the study was to examine the quality of life amongst acute CHD patients.
  2. The preventive effect of physical activity on weight maintenance in overweight and obese women
    Dashti S, Esfehani AJ, Leonard Joseph HJ
    Clin Ter, 2014;165(3):155-61.
    PMID: 24999570 DOI: 10.7417/CT.2014.1715
    Prevalence of obesity has increased recently especially in women. Obesity is related to mortality due to non-communicable diseases and has become a public health issue. Among the two important factors to reduce weight calorie limitation alone is modestly effective in initial weight but can result in weight gain after primary weight reduction is common. Therefore adding physical activity to weight maintenance program can reduce weight gain rebound. The aim of this review article was to identify the preventive effect of physical activity on weight maintenance in overweight women. Articles were selected from PubMed database and screened for the relativity to the study objectives, using scoring systems. Eleven studies were found appropriate. No statistical test was done on the data except simple mean and some descriptive analyses. Physical activity is proved to have a significant effect in weight loss/maintenance both in induction and maintenance period. This effect was more significant in higher intensities. Sever intensity physical activity can be effective in weight maintenance in long term but the effect of moderate and light physical activity could not be evaluated due to lack of data.
  3. The predictive values of urinalysis in intravenous urogram. Is intravenous urography really necessary in mild hydronephrotic patient?
    Hamzaini AH, Helmee MN, Masoud S, Suraya A, Nazri MS, Das S
    Clin Ter, 2009;160(6):473-5.
    PMID: 20198290
    BACKGROUND AND AIMS: Many patients who presented to Universiti Kebangsaan Malaysia Medical Centre (UKMMC) with signs and symptoms of urolithiasis had mild hydronephrosis with non visualization of calculus on ultrasound examination. These patients underwent an intravenous urogram (IVU) in order to determine the presence of urolithiasis and most of them had normal IVU. The main aim of this study was to determine the predictive value of urinalysis in this group of patients in determining the need for IVU examinations.
    MATERIALS AND METHODS: Retrospectively the ultrasound, urinalysis and intravenous urography reports of 53 patients were reviewed and evaluated.
    RESULTS: The positive predictive and negative predictive value of urinalysis was found to be 68% and 96.4%, respectively. CONCLUSIONS; The results indicate that the urinalysis was an excellent negative predictor for IVU. In view of high radiation dose, risk of contrast reaction and contrast induced nephropathy of IVU, we suggest that it should not be performed in patient with non visualization of calculus mild hydronephrosis when the urinalysis is negative for blood.

    Study site: Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
  4. Fulltext The potential role of herbal products in the treatment of Parkinson's disease
    Amro MS, Teoh SL, Norzana AG, Srijit D
    Clin Ter, 2018 2 16;169(1):e23-e33.
    PMID: 29446788 DOI: 10.7417/T.2018.2050
    Parkinson's disease (PD) is a multifactorial disorder of the nervous system in which there is a progressive loss of dopaminergic neurons. There is a disturbance in the movement in PD and these include resting tremors, rigidity, bradykinesia or akinesia, disturbance, posture and freezing (motor block). The substantia nigra and other parts of the brain are commonly affected. The disorder could be related to oxidative stress and there is an important role of reactive oxygen species (ROS). A number of herbal products contain active components which are known to possess antioxidant action. Hence, the potential role of herbal products in treating PD cannot be undermined. In the present narrative review, the main aim is to discuss the pathogenesis of PD, define the role of different potential herbal extracts on its pathogenesis which may form the basis of treatment. We also discuss in detail the active chemical compounds present each herb which are effective in the treatment of PD. These herbs include Baicalei, Erythrina velutin, Resveratrol, Peganum Harmal, Curcuma longa (Zingiberaceae), Carthamus tinctorius L. (Safflower), Pueraria lobate, Juglandis Semen (Walnut), Tianma Gouteng Yin (TGY), Lycium barbarum L fruit, Mucuna pruriens (Velvet bean), Chunghyuldan (CHD), Paeoniae Alba Radix. The present review may be beneficial for designing future drugs for effective treatment of PD.
  5. The patients' understanding on the status and role of anaesthesiologists
    Budiman M, Izaham A, Abdul Manap N, Zainudin K, Kamaruzaman E, Masdar A, et al.
    Clin Ter, 2015 Nov-Dec;166(6):227-35.
    PMID: 26794808 DOI: 10.7417/CT.2015.1892
    OBJECTIVES: To evaluate patients' understanding on the status and role of anaesthesiologists.
    MATERIALS AND METHODS: This was a prospective, questionnaire-based cross-sectional study. The interview had three segments which questioned on (i) patients' knowledge of the qualification, training and role of anaesthesiologists, (ii) attitude of patients towards anaesthesia and anaesthesiologists and (iii) the demographic data of patients.
    RESULTS: Of 384 patients interviewed, 59.4% had prior anaesthesia experience. Most patients (95.6%) knew that anaesthesiologists were medical doctors, but only 27.1% knew the duration of training required to attain this specialist qualification. Patients' awareness of the various anaesthetic responsibilities was 12.2% in managing labour pain, 25.5% in intensive care units, 49.2% in chronic pain and 99.5% in postoperative pain management. During surgery, 73.7% of patients knew that anaesthesiologists were monitoring their vital signs, but only 42.2% thought anaesthesiologists also treated medical problems intraoperatively. Most patients (95.1%) would like to meet their anaesthesiologists prior to the operation and 97.7% want them to inform all possible anaesthesia complications.
    CONCLUSIONS: Our patients' understanding and awareness of the status and roles of anaesthesiologists are still limited and variable. This can be further improved with patient interaction and public education.
    KEYWORDS: Anaesthesiologist; Attitudes; Patient’s knowledge; Patient’s perception; Survey
  6. The ideal measurement of the quality of life in post stroke patients: an urban study
    Samsiah M, Das S, Chee SY, Rashidah R, Siti H, Ruth P, et al.
    Clin Ter, 2011;162(3):209-15.
    PMID: 21717044
    There is paucity of literature on the measurement of the quality of life in post stroke patients in the developing countries. The main objective of this study was to determine the quality of life (QOL) of post stroke patients.
  7. The harmful effects of consumption of repeatedly heated edible oils: a short review
    Ku SK, Muhamad Ruhaifi MS, Fatin SS, Saffana M, Taty Anna K, Das S, et al.
    Clin Ter, 2014;165(4):217-21.
    PMID: 25203337 DOI: 10.7417/CT.2014.1737
    It has been a regular practice to repeatedly heat the cooking oil and consume it without knowing the harmful effects of such. The procedure to use repeatedly heated cooking oil is aimed to curb the cost of expenses. Heating results is the formation of free reactive oxygen species (ROS) which is responsible for the oxidative stress and damage to various organs in the body. The present review article discusses the harmful events occurring due to consumption of repeated heating of edible oil. A strong message is aimed to generate public awareness of the deleterious effects of consumption of heated edible oil which may help in curbing hypertension and atherosclerosis.
  8. The effect of Piper betel extract on the wound healing process in experimentally induced diabetic rats
    Keat EC, Razak SS, Fadil NM, Yusof FM, Chan LH, Chyi FK, et al.
    Clin Ter, 2010;161(2):117-20.
    PMID: 20499023
    Piper betel (PB) possesses antimicrobial, antifungal, antioxidant and wound healing properties due to its powerful antioxidant effect. Diabetes mellitus (DM) is a metabolic disorder which is associated with complications like impaired wound healing, nephropathy and neuropathy. The main aim of the study was to study the wound healing properties of PB.
  9. The accessory foramen ovale of the skull: an osteological study
    Abd Latiff A, Das S, Sulaiman IM, Hlaing KP, Suhaimi FH, Ghazalli H, et al.
    Clin Ter, 2009;160(4):291-3.
    PMID: 19795082
    The sphenoid bone is known to have several foramina and the foramen ovale is one amongst them. The foramen ovale transmits the mandibular nerve, accessory meningeal artery, lesser petrosal nerve and the emissary veins. There have been past reports on the variations of the different foramina present in the skull but there are no reports on the variations of the skull foramina from any of the South-East Asian countries. The present study aims to highlight the presence of an accessory foramen ovale in the skull in Malaysian population. Both sides of fifteen adult skulls (n = 30) were taken for observation of any variations in the foramen ovale. We observed the presence of accessory foramen ovale on the left side of a single skull (3.33%). The minute accessory foramen ovale was located 0.1 cm medial to the normal foramen ovale. The anomalous accessory foramen ovale was circular in shape and measured 0.1 cm in diameter. Anatomical knowledge of the foramen ovale is important for all neurosurgical procedures involving the trigeminal nerve and administration of anaesthesia in the mandibular nerve. Interestingly, the percutaneous biopsy of the cavernous sinus is also performed through the foramen ovale. Prior knowledge of the presence of an accessory foramen ovale may be important for academic, anthropological, forensic and clinical purpose and the present study aims to highlight such.
  10. The Internal Reliability of Family Crisis Oriented Personal Evaluation Scale (F-COPES) in Malay version among caregivers of individual with learning disabilities
    Alwi N, Harun D, Omar B, Ahmad M, Zagan M, Leonard JH
    Clin Ter, 2015 Nov-Dec;166(6):e361-4.
    PMID: 26794817 DOI: 10.7417/T.2015.1901
    Caregivers face challenges to adapt while handling individual with learning disabilities (LD). The Family Crisis Oriented Personal Evaluation Scale (F-COPES) is a widely used instrument to measure coping strategies among caregivers. The current study performed cross cultural translation of F-COPES in Malay language. This study aims to examine the reliability by testing internal consistency of Malay version of F-COPES which is developed through back to back translation method from original English version.
  11. The Accuracy of Sex Estimation on Metatarsal Bones in a Northeastern Thai Population
    Phatsara M, Das S, Laowatthanaphong S, Tuamsuk P, Mahakkanukrauh P
    Clin Ter, 2016 May-Jun;167(3):72-6.
    PMID: 27424506 DOI: 10.7417/CT.2016.1929
    BACKGROUND: This study was carried out to evaluate the accuracy of sex estimation by discriminant analysis and stepwise discriminant analysis equations generated from metatarsal bones in a Thai population.
    MATERIAL AND METHODS: The testing samples utilized in this study consisted of 50 skeletons (25 males and 25 females) obtained from the Khon Kaen University Skeletal Collection, Department of Anatomy, Faculty of Medicine, Khon Kaen University. Seven measurements of metatarsal bones were measured in centimeters, using either a mini-osteometric board (MOB) or a sliding caliper. The values measured from the Khon Kaen Skeletal Collection were used to determine the accuracy and applicability of sex determination, as predicted by Y1-Y6 equations which were generated from a Chiang Mai Skeletal Collection.
    RESULTS: The percentage of sex determination accuracies predicted from the Y1-Y6 equations demonstrated accuracy rates of 80-95.6.
    CONCLUSIONS: The Chiang Mai sex determination equations, generated from metatarsal bones by discriminant analysis (Y1-Y3) and stepwise discriminant analysis (Y4-Y6), demonstrated high accuracy rates of prediction, suggesting that these equations may be useful for sex determination within the Thai population.
    KEYWORDS: Foot; Metatarsal bones; Sex determination; Thailand
  12. Test of Sex Estimation Equations on Carpal Bones in a Northeastern Thai Population
    Laowatthanaphong S, Das S, Phatsara M, Tuamsuk P, Mahakkanukrauh P
    Clin Ter, 2016 Mar-Apr;167(2):29-32.
    PMID: 27212569 DOI: 10.7417/CT.2016.1917
    Sex assessment is an essential step in person identification, both in forensic and anthropological contexts. Many parts of skeletal remains such as skull, pelvis and long bones have been proven to be useful in determining sex. However, literature has shown that short bones such as carpal bones are also sexually dimorphic. In the last few years, there was an unpublished study using lunate, scaphoid and hamate from bone collection in Northern Thailand to create 6 discriminant equations to assess sex. The objective of this study was to investigate the application of those equations in the sample from other parts of Thailand.
  13. Tear evaluation of subjects wearing rigid gas permeable contact lens for six months: the Asian context
    Mohd-Ali B, Leong SF, Abdul-Mutalib H, Mohidin N
    Clin Ter, 2011;162(4):327-30.
    PMID: 21912820
    OBJECTIVE: Asians are known to have different tear characteristics compared to Caucasians that may affect contact lens wear. There are scanty research studies that have evaluated tears during continuous wear contact lens in Asia. The present study aims to evaluate changes in tears in subjects wearing continuous wear rigid gas permeable contact lens (CWRGP) for 6 months.
    MATERIALS AND METHODS: Thirty five neophyte subjects (21 females, 14 females) were recruited for this study. Subjects were fitted with CWRGP lenses with Dk of 163 on both eyes. Tear was evaluated using Phenol red thread test (PRT), tear break up time (TBUT) test and tear meniscus height (TMH) measurement. Non parametric and parametric analyses were used to compare the parameters.
    RESULTS: Values at baseline (BL) and six months (6M) were as follow: PRT, BL=19.10 ± 3.86 mm, 6M= 21.02 ± 4.27 mm, TBUT, BL= 8.58 ± 4.90 sec, 6M=8.08 ± 5.32 sec, TMH, BL= 0.38 ± 0.12 mm, 6M= 0.34 ± 0.07 mm. Statistical analysis showed significant difference in tear volume for PRT only at 6 months (p=0.007).
    CONCLUSION: Our analysis showed minimal change in the tear characteristics after six months of CWRGP lens wear, which indicated low impact of CWRGP contact lens on tears characteristics of Asian eyes. However, careful monitoring is required to prevent development of adverse events during contact lens wear.
  14. Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts
    Durani LW, Jaafar F, Tan JK, Tajul Arifin K, Mohd Yusof YA, Wan Ngah WZ, et al.
    Clin Ter, 2016;166(6):e365-73.
    PMID: 26794818 DOI: 10.7417/T.2015.1902
    Tocotrienols have been known for their antioxidant properties besides their roles in cellular signalling, gene expression, immune response and apoptosis. This study aimed to determine the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing cellular senescence of human diploid fibroblasts (HDFs) by targeting the genes in senescence-associated signalling pathways.
  15. Fulltext Susceptibility of Bacillus subtilis to Zinc Oxide Nanoparticles Treatment
    Djearamane S, Sundaraji A, Eng PT, Liang SXT, Wong LS, Senthilkumar B
    Clin Ter, 2023;174(1):61-66.
    PMID: 36655646 DOI: 10.7417/CT.2023.2498
    AIM: With the characteristics such as low toxicity, high total surface, ability to inhibit the growth of pathogenic microorganisms, zinc oxide nanoparticles (ZnO NPs), as one of the metallic nanoparticles, have been chosen as an antibacterial agent to treat various skin infections. The present study was aimed to determine the antibacterial potential of ZnO NPs on Bacillus subtilis, the Gram-positive bacterium that can cause skin and wound infections.

    METHODS: B. subtilis was exposed to 5 to 150 μg/mL of ZnO NPs for 24 h. The parameters employed to evaluate the antimicrobial potential of ZnO NPs were the growth inhibitory effect on B. subtilis, the surface interaction of ZnO NPs on the bacterial cell wall, and also the morphological alterations in B. subtilis induced by ZnO NPs.

    RESULTS: The results demonstrated a significant (p <0.05) inhibition of ZnO NPs on B. subtilis growth and it was in a dose-dependent manner for all the tested concentrations of ZnO NPs from 5 to 150 μg/mL at 24 h. Fourier transformed infrared (FTIR) spectrum confirmed the involvement of polysaccharides and polypeptides of bacterial cell wall in surface binding of ZnO NPs on bacteria. The scanning electron microscopy (SEM) was used to visualize the morphological changes, B. subtilis illustrated several surface alterations such as distortion of cell membrane, roughening of cell surface, aggregation and bending of cells, as well as, the cell rupture upon interacting with ZnO NPs for 24 h.

    CONCLUSION: The results indicated the potential of ZnO NPs to be used as an antibacterial agent against B. subtilis. The findings of the present study might bring insights to incorporate ZnO NPs as an antibacterial agent in the topical applications against the infections caused by B. subtilis.

  16. Successful free omental flap and skin graft reconstruction of scalp avulsion injury
    Ramzisham AR, Somasundaram S, Nasir ZM, Ali F, Das S
    Clin Ter, 2010;161(5):453-5.
    PMID: 20949243
    For the management of a full-thickness scalp avulsion injury, thorough wound debridement and immediate primary revascularization or a split-thickness skin graft may be necessary. Graft failure may be common situation thereby predisposing the individuals to unnecessary multiple operations. In the recent times, the use of omental graft has gained much popularity. In the present study, we describe an interesting case of chronic non healing scalp ulcer in a young woman who eventually underwent a free omental flap reconstruction with split-thickness skin graft and had satisfactory outcome.
  17. Study on advanced life support devices in the ambulances for emergency cases in Klang Valley, Malaysia
    Ismail MS, Hasinah AB, Syaiful MN, Murshidah HB, Thong TJ, Zairi Z, et al.
    Clin Ter, 2012;163(2):115-22.
    PMID: 22555825
    In an effort to improve pre-hospital care, the authors assessed the availability and utility of ambulance devices. The study aimed to identify commonly used devices for managing emergency cases in Klang Valley of Malaysia.
  18. Stature Estimation from Lower Limb Anthropometry using Linear Regression Analysis: A Study on the Malaysian Population
    Abu Bakar SN, Aspalilah A, AbdelNasser I, Nurliza A, Hairuliza MJ, Swarhib M, et al.
    Clin Ter, 2017 Mar-Apr;168(2):e84-e87.
    PMID: 28383619 DOI: 10.7417/CT.2017.1988
    INTRODUCTION: Stature is one of the characteristics that could be used to identify human, besides age, sex and racial affiliation. This is useful when the body found is either dismembered, mutilated or even decomposed, and helps in narrowing down the missing person's identity.

    AIM: The main aim of the present study was to construct regression functions for stature estimation by using lower limb bones in the Malaysian population.

    MATERIALS AND METHODS: The sample comprised 87 adult individuals (81 males, 6 females) aged between 20 to 79 years. The parameters such as thigh length, lower leg length, leg length, foot length, foot height and foot breadth were measured. They were measured by a ruler and measuring tape. Statistical analysis involved independent t-test to analyse the difference between lower limbs in male and female. The Pearson's correlation test was used to analyse correlations between lower limb parameters and stature, and the linear regressions were used to form equations. The paired t-test was used to compare between actual stature and estimated stature by using the equations formed.

    RESULTS: Using independent t-test, there was a significant difference (p< 0.05) in the measurement between males and females with regard to leg length, thigh length, lower leg length, foot length and foot breadth. The thigh length, leg length and foot length were observed to have strong correlations with stature with p= 0.75, p= 0.81 and p= 0.69, respectively. Linear regressions were formulated for stature estimation. Paired t-test showed no significant difference between actual stature and estimated stature.

    CONCLUSIONS: It is concluded that regression functions can be used to estimate stature to identify skeletal remains in the Malaysia population.
  19. Spot urine potassium as a potential screening test for aldosterone breakthrough
    Sakthiswary R, Wong M, Isa ZM, Nor Azmi K
    Clin Ter, 2012;163(3):195-8.
    PMID: 22964690
    Treatment with angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) may suppress aldosterone production only in the initial phase of treatment and subsequently lead to a rising level of aldosterone to baseline or higher. This phenomenon is described as aldosterone breakthrough. Apart from serial plasma aldosterone levels, there are no other test to identify this condition. The purpose of this study was to evaluate the role of spot urine potassium as a potential screening test for aldosterone breakthrough.
  20. Spinal arteriovenous malformation presenting with prolapsed intervertebral disc: a diagnostic dilemma
    Farina MY, Harunarashid H, Faridzal F, Jegan T, Das S
    Clin Ter, 2012 Nov;163(6):491-3.
    PMID: 23306743
    The availability of multiple investigating modalities should be utilized to arrive at the correct diagnosis of the spinal arteriovenous malformation (AVM). We hereby report the case of a 21-year-old, obese female, who presented with paraplegia and impaired bowel control two years after an episode of the fall. The Magnetic Resonance Imaging (MRI) of her spine not only revealed disc prolapse at T11-T12, but also tortuous dilated spinal veins and cord oedema. A diagnosis of a spinal arterio-venous fistula was confirmed after a spinal angiogram. The dilemma of treating the right pathology for the clinical signs and symptoms are being discussed.
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