Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts

Durani LW 1 , Jaafar F 1 , Tan JK 1 , Tajul Arifin K 1 , Mohd Yusof YA 1 , Wan Ngah WZ 1 Show all authors , Makpol S 1

Affiliations 

  • 1 Department of Biochemistry, Faculty of Medicine, Level 17, Preclinical Building, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
Clin Ter, 2016;166(6):e365-73.
PMID: 26794818 DOI: 10.7417/T.2015.1902

Abstract

Tocotrienols have been known for their antioxidant properties besides their roles in cellular signalling, gene expression, immune response and apoptosis. This study aimed to determine the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing cellular senescence of human diploid fibroblasts (HDFs) by targeting the genes in senescence-associated signalling pathways.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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