Tumour cells behave differently than normal cells in the body. They grow and
divide in an uncontrolled manner (actively proliferating) and fail to respond to signal.
However, there are cells that become inactive and reside in quiescent phase (G0). These
cells are known as quiescence cells that are less sensitive to drug treatments (radiotherapy
and chemotherapy) than actively proliferation cells. This paper proposes a new mathe-
matical model that describes the interaction of tumour growth and immune response by
considering tumour population that is divided into three different phases namely inter-
phase, mitosis and G0. The model consists of a system of delay differential equations
where the delay, represents the time for tumour cell to reside interphase before entering
mitosis phase. Stability analysis of the equilibrium points of the system was performed
to determine the dynamics behaviour of system. Result showed that the tumour popu-
lation depends on number of tumour cells that enter active (interphase and mitosis) and
G0phases. This study is important for treatment planning since tumour cell can resist
treatment when they refuge in a quiescent state.
Analyzed the effects of thermal radiation, chemical reaction, heat gener-
ation/absorption, magnetic and electric fields on unsteady flow and heat transfer of
nanofluid. The transport equations used passively controlled. A similarity solution is
employed to transformed the governing equations from partial differential equations to
a set of ordinary differential equations, and then solve using Keller box method. It was
found that the temperature is a decreasing function with the thermal stratification due to
the fact the density of the fluid in the lower vicinity is much higher compared to the upper
region, whereas the thermal radiation, viscous dissipation and heat generation enhanced
the nanofluid temperature and thermal layer thickness.
Coxmodel is popular in survival analysis. In the case of time-varying covariate;
several subject-specific attributes possibly to change more frequently than others. This
paper deals with that issue. This study aims to analyze survival data with time-varying
covariate using a time-dependent covariate Cox model. The two case studies employed in
this work are (1) delisting time of companies from IDX and (2) delisting time of company
from LQ45 (liquidity index). The survival time is the time until a company is delisted
from IDX or LQ45. The determinants are eighteen quarterly financial ratios and two
macroeconomics indicators, i.e., the Jakarta Composite Index (JCI) and BI interest rate
that changes more frequent. The empirical results show that JCI is significant for both
delisting and liquidity whereas BI rate is significant only for liquidity. The significant
firm-specific financial ratios vary for delisting and liquidity.
A new topic of Zero Energy Building (ZEB) is getting famous in research area
because of its goal of reaching zero carbon emission and low building cost. Renewable
energy system is one of the ideas to achieve the objective of ZEB. Genetic Algorithm (GA)
is widely used in many research areas due to its capability to escape from a local minimal
to obtain a better solution. In our study, GA is chosen in sizing optimization of the
number of photovoltaic, wind turbine and battery of a hybrid photovoltaic-wind-battery
system. The aim is to minimize the total annual cost (TAC) of the hybrid energy system
towards the low cost concept of ZEB. Two GA parameters, which are generation number
and population size, have been analysed and optimized in order to meet the minimum
TAC. The results show that the GA is efficient in minimizing cost function of a hybrid
photovoltaic-wind-battery system with its robustness property.
The proposed modified methods of Cramer's rule consider the column vector as well as the coefficient matrix concurrently in the linear system. The modified methods can be applied since Cramer's rule is typically known for solving the linear systems in $WZ$ factorization to yield Z-matrix. Then, we presented our results to show that there is no tangible difference in performance time between Cramer's rule and the modified methods in the factorization from improved versions of MATLAB. Additionally, the Frobenius norm of the modified methods in the factorization is better than using Cramer's rule irrespective of the version of MATLAB used.
Life table is a table that shows mortality experience of a nation. However, in Malaysia, the information in this table is provided in the five-years age groups (abridged) instead of every one-year age. Hence, this study aims to estimate the one-year age mor- tality rates from the abridged mortality rates using several interpolation methods. We applied Kostaki method and the Akima spline method to five sets of Malaysian group mortality rates ranging from period of 2012 to 2016. The result were then compared with the one-year mortality rates. We found that the method by Akima is the best method for Malaysian mortality experience as it gives the least minimum of sum of square errors. The method does not only provide a good fit but also, shows a smooth mortality curve.
This paper revisits the comrade matrix approach in finding the greatest com-
mon divisor (GCD) of two orthogonal polynomials. The present work investigates on the
applications of the QR decomposition with iterative refinement (QRIR) to solve certain
systems of linear equations which is generated from the comrade matrix. Besides iterative
refinement, an alternative approach of improving the conditioning behavior of the coeffi-
cient matrix by normalizing its columns is also considered. As expected the results reveal
that QRIR is able to improve the solutions given by QR decomposition while the nor-
malization of the matrix entries do improves the conditioning behavior of the coefficient
matrix leading to a good approximate solutions of the GCD.
In this paper, we propose a method how to manage the convergence of
Newton’s method if its iteration process encounters a local extremum. This idea establishes
the osculating circle at a local extremum. It then uses the radius of the
osculating circle also known as the radius of curvature as an additional number of
the local extremum. It then takes that additional number and combines it with the
local extremum. This is then used as an initial guess in finding a root near to that
local extremum. This paper will provide several examples which demonstrate that the
proposed idea is successful and they perform to fulfill the aim of this paper.
Dengue is a mosquito-borne disease caused by virus and found mostly in urban and semi-urban areas, in many regions of the world. Female Aedes mosquitoes, which usually bite during daytime, spread the disease. This flu-like disease may progress to severe dengue and cause fatality. A generic reaction-diffusion model for transmission of mosquito-borne diseases was proposed and formulated. The motivation is to explore the ability of the generic model to reproduce observed dengue cases in Borneo, Malaysia. Dengue prevalence in four districts in Borneo namely Kuching, Sibu, Bintulu and Miri are compared with simulations results obtained from the temporal and spatio-temporal generic model respectively. Random diffusion of human and mosquito populations are taken into account in the spatio-temporal model. It is found that temporal simulations closely resemble the general behavior of actual prevalence in the three locations except for Bintulu. The recovery rate in Bintulu district is found to be the lowest among the districts, suggesting a different dengue serotype may be present. From observation, the temporal generic model underestimates the recovery rate in comparison to the spatio-temporal generic model.
Subsea cable laying process is a difficult task for an engineer due to many
uncertain situations which occur during the operation. It is very often that the cable being
laid out is not perfectly fit on the route being planned, which results in the formation of
slack. In order to control wastages during installation, the slack needs to be minimized
and the movement of a ship/vessel needs to be synchronized with the cable being laid out.
The current problem was addressed using a mathematical model by considering a number
of defining parameters such as the external forces, the cable properties and geometry. Due
to the complexity, the model is developed for a steady-state problem assuming velocity
of the vessel is constant, seabed is flat and the effect of wind and wave is insignificant.
Non-dimensional system is used to scale the engineering parameters and grouped them
into only two main parameters which are the hydrodynamic drag of the fluid and the
bending stiffness of the cable. There are two solutions generated in this article; numerical
and asymptotic solutions. The result of these solutions suggests that the percentage of
slack can be reduced by the increase of the prescribed cable tension, and also the increase
in either the drag coefficient of the sea water or the bending stiffness of the cable, similarly
will result in lower slack percentage
Simulation is used to measure the robustness and the efficiency of the forecasting
techniques performance over complex systems. A method for simulating multivariate
time series was presented in this study using vector autoregressive base-process. By
applying the methodology to the multivariable meteorological time series, a simulation
study was carried out to check for the model performance. MAPE and MAE performance
measurements were used and the results show that the proposed method that consider
persistency in volatility gives better performance and the accuracy error is six time smaller
than the normal hybrid model.
The box plot has been used for a very long time since 70s in checking the existence
of outliers and the asymmetrical shape of data. The existing box plot is constructed
using five values of statistics calculated from either the discrete or continous data. Many
improvement of box plots have deviated from the elegant and simplier approach of exploratory
data analysis by incorporating many other statistic values resulting the turning
back of the noble philosophy behind the creation of box plot. The modification using
range value with the minimum and maximum values are being incorporated to suit the
need of selected discrete distribution when outliers is not an important criteria anymore.
The new modification of box plot is not based on the asymmetrical shape of distribution
but more on the spreading and partitioning data into range measure. The new propose
name for the box plot with only three values of statistics is called range-box plot.
In this paper we consider a harvesting model of predator-prey fishery in which
the prey is directly infected by some external toxic substances. The toxic infection is
indirectly transmitted to the predator during the feeding process. The model is a modified
version from the classic Lotka-Volterra predator-prey model. The stability and bifurcation
analyses are addressed. Numerical simulations of the model are performed and bifurcation
diagrams are studied to investigate the dynamical behaviours between the predator and
the prey. The effects of toxicity and harvesting on the stability of steady states found in
the model are discussed.
It has come to attention that Malaysia have been aiming to build its own
nuclear power plant (NPP) for electricity generation in 2030 to diversify the national
energy supply and resources. As part of the regulation to build a NPP, environmental
risk assessment analysis which includes the atmospheric dispersion assessment has to
be performed as required by the Malaysian Atomic Energy Licensing Board (AELB)
prior to the commissioning process. The assessment is to investigate the dispersion of
radioactive effluent from the NPP in the event of nuclear accident. This article will focus
on current development of locally developed atmospheric dispersion modeling code
based on Gaussian Plume model. The code is written in Fortran computer language
and has been benchmarked to a readily available HotSpot software. The radionuclide
release rate entering the Gaussian equation is approximated to the value found in the
Fukushima NPP accident in 2011. Meteorological data of Mersing District, Johor of
year 2013 is utilized for the calculations. The results show that the dispersion of radionuclide
effluent can potentially affect areas around Johor Bahru district, Singapore
and some parts of Riau when the wind direction blows from the North-northeast direction.
The results from our code was found to be in good agreement with the one
obtained from HotSpot, with less than 1% discrepancy between the two.
Logging activity is one of the most important activities for tropical countries
including Malaysia, as it produces quality trees for papers. One of the important tree
species is the Acacia Mangium which it produces a soft tree for papermaking enterprises.
The papers are exported to Europe and countries which have high demand for paper
due to the rapid development of the printing industry. Thus we analyzed the height for
individual trees. We investigate the maximum height of the trees from 1990 to 2006
and we fit the data using extreme value model. Some of the data are missing and three
imputation methods we used to solve this problem.
The well-known geostatistics method (variance-reduction method) is commonly used to determine the optimal rain gauge network. The main problem in geostatistics method to determine the best semivariogram model in order to be used in estimating the variance. An optimal choice of the semivariogram model is an important point for a good data evaluation process. Three different semivariogram models which are Spherical, Gaussian and Exponential are used and their performances are compared in this study. Cross validation technique is applied to compute the errors of the semivariograms. Rain-fall data for the period of 1975 – 2008 from the existing 84 rain gauge stations covering the state of Johor are used in this study. The result shows that the exponential model is the best semivariogram model and chosen to determine the optimal number and location of rain gauge station.
Invadopodia are finger-like protrusions located at subcellular membrane which can lead to cancer cell invasion. The formation of invadopodia involves several steps such as actin polymerizations, degradation of extracellular matrix which produce ligand and signal stimulation that is occurred from the binding of ligand with epidermal growth factor receptor. In this paper, a mathematical model of signal transduction is investigated. Both signal and ligand are represented by Laplace equation with Dirichlet boundary condition for each region. The cell membrane is treated as free boundary surface to separate any activity that occurred in intracellular and extracellular regions. The motion of the interface is taken as gradient of interior signal and the cell membrane is set as zero level set function. The problem is solved numerically using finite difference scheme of upwind, interpolation and extrapolation methods. The results showed that the formation of invadopodia is formed when protrusions exist on the cell membrane.
The hydromagnetic mixed convection flow of Cassonnano fluid under the influence of chemical reaction,thermal radiation and heat generation or absorption is investigated. The flow is induced due to unsteady nonlinearly stretching sheet saturated in a porous medium. The governing nonlinear coupled partial differential equations are converted into the system of coupled ordinary differential equations using similarity transformations and then solved numerically via Keller box method. The effects of pertinent parameters on velocity, temperature and nanoparticles concentration as well as wall shear stress, heat and mass transfer rate are analyzed and displayed graphically. The results for skin friction coefficient and local Nusselt number are compared with previously published work and found to be in good agreement. Findings demonstrate that increase in Casson parameter enhanced the friction factor and heat transfer rate. It is noticed that the heat transfer rate is declined with increment in Brownian motion and thermophoresis parameters. The nanoparticles concentration is seen to be higher in generative chemical reaction and opposite effect is observed in destructive chemical reaction. Increase in unsteadiness parameter decreased the fluid velocity, temperature and nanoparticles concentration. The magnitude of wall shear stress is also reduced with increase in unsteadiness and porous medium parameters.
The constraint of two ordered extreme minima random variables when one
variable is consider to be stochastically smaller than the other one has been carried
out in this article. The quantile functions of the probability distribution have been
used to establish partial ordering between the two variables. Some extensions and
generalizations are given for the stochastic ordering using the important of sign of the
shape parameter.
1Malaysia
2 (UKM)43600 Bangi, Selangor, Malaysia
∗Corresponding author:
Numerous studies have linked biodiversity with zoonotic disease control. However, researchers have warned against simply believing that the increase in biodiversity can reduce the infection disease in the community. They proposed that amplification effect (increase in biodiversity accompanied by an increase in disease prevalence) might sometimes occur. Thus, we formulated a deterministic model to consider the impact of an amplification or dilution agent on the SNV transmission in the deer mouse population. Bifurcation analysis was carried out to examine the combined influences of the environmental carrying capacity, the interspecific competition strength and the impact of amplification or dilution agent on the deer mouse population. Our results showed that the system with amplification agent required a higher carrying capacity or stronger interspecific strength to compensate for its amplification effect in suppressing the SNV prevalence; this situation explains the lack of reduction in SNV prevalence despite the presence of high biodiversity in some empirical studies. In this study, we highlight the importance of investigating the roles of the additional species in an assemblage to better understand their relationship with the SNV prevalence in deer mouse population.