METHODS: Firstly, grounded theory (GT) was used to analyze interview data to extract consumer demand indicators and construct a design evaluation hierarchical model. Secondly, the Analytical Hierarchy Process (AHP) was used to calculate the weights of the indicators, determine their priority of importance, and obtain several indicators that have a greater impact on the tea set design to guide innovative design practice. Lastly, the tea set design schemes were evaluated using the fuzzy comprehensive evaluation method to select the optimal design scheme and also to act as a guideline for further design optimization.
CONCLUSION: This study explores the innovative design and evaluation method for tea set products based on GT-AHP-FCE and validates the feasibility of this approach through a practical example of tea set design inspired by "The Classic of Mountains and Seas.". It provides innovative theoretical and practical guidance for designers of subsequent tea set products and also provides a new path for the inheritance and innovation of traditional culture.
METHODS: University students from Jiangsu Province participated in this study. Participants completed self-report surveys assessing emotion regulation strategies. It was conducted from May 2022 to July 2022. The study employed confirmatory factor analysis (CFA) to assess the two-factor model of ERQ-8 and measurement invariance across male and female samples.
RESULTS: The mean age of 1534 participants was 19.83 years (SD = 1.54), and the majority were female (70.4%). The initial ERQ-10 model with ten items demonstrated good fit for all indicators, CFI (Comparative Fit index) = 0.967, TLI (Tucker-Lewis Index) = 0.957, RMSEA (Root Mean Square Error of Approximation) = 0.043, SRMR (Standardised Root Mean Square Residual) = 0.029. However, to assess the fit of the previously proposed ERQ-8 model, two items (Q1 and Q3) were excluded. The fit of the ERQ-8 model was further improved (CFI = 0.989, TLI = 0.984, RMSEA = 0.029, SRMR = 0.021). All item loadings exceeded or were equal to 0.573. Internal consistency analysis based on the ERQ-8 model revealed Cronbach's alpha values of 0.840 for reappraisal and 0.745 for suppression, and corresponding composite reliability (CR) values of 0.846 and 0.747, respectively. Test-retest reliability, assessed using the intraclass correlation coefficient (ICC) (95% CI) within a one-week interval, ranged from 0.537 to 0.679. The correlation coefficient between the two factors was 0.084, significantly below 0.85, which suggested a low correlation between the two factors. The results of the invariance analysis across gender demonstrated that the values of ΔCFI and ΔTLI were both below 0.01. It was supported the gender invariance of the ERQ-8 among university students.
CONCLUSION: The eight-item ERQ demonstrated validity and reliability in evaluating emotion regulation strategies, and measurement invariance was observed across gender among university students. The ERQ-8 may prove to be a practical and cost-effective tool, particularly in time-constrained situations.
OBJECTIVE: This study aimed to translate the Smartphone Addiction Scale-Short Version (SAS-SV) into Chinese and evaluate the psychometric characteristics of the Smartphone Addiction Scale- Chinese Short version (SAS-CSV) among Chinese college students.
METHODS: The SAS-SV was translated into Chinese using the forward-backward method. The SAS-CSV was completed by 557 Chinese college students (sample 1: n = 279; sample 2: n = 278). 62 college students were randomly selected from the 557 Chinese college students to be meas- ured twice, with an interval of two weeks. The reliability of the SAS-CSV was evaluated by internal consistency reliability and test-retest reliability, and the validity of the SAS-CSV was evaluated by content validity, structural validity, convergent validity, and discriminant validity.
RESULTS: The SAS-CSV presented good content validity, high internal consistency (sample 1: α = 0.829; sample 2: α = 0.881), and good test-retest reliability (ICC: 0.975; 95% CI: 0.966-0.985). After one exploratory factor analysis, three components (tolerance, withdrawal, and negative effect) with eigenvalues greater than 1 were obtained, and the cumulative variance contribution was 50.995%. The results of confirmatory factor analysis indicated that all the fit indexes reached the standard of good model fit (χ2/df = 1.883, RMSEA = 0.056, NFI = 0.954, RFI = 0.935, IFI = 0.978, TLI = 0.969, CFI = 0.978). The SAS-CSV presented good convergent validity for the factor loading of all the items ranged from 0.626 to 0.892 (higher than 0.50), the three latent variables' AVE ranged from 0.524 to 0.637 (higher than 0.50), and the three latent variables' CR ranged from 0.813 to 0.838 (higher than 0.70). Moreover, the square roots of the AVE of component 1 (tolerance), component 2 (withdrawal) and component 3 (negative effect) were 0.724, 0.778, and 0.798, respectively, higher than they were with other correlation coefficients, indicating that the SAS-CSV had good discrimination validity.
CONCLUSION: The SAS-CSV is a valid instrument for measuring smartphone addiction among Chinese college students.
OBJECTIVE: To examine the associations of change in body mass index (BMI), waist circumference, and percent fat mass with change in intraocular pressure (IOP) in a large sample of Korean adults.
DESIGN, SETTING AND PARTICIPANTS: Cohort study of 274,064 young and middle age Korean adults with normal fundoscopic findings who attended annual or biennial health exams from January 1, 2002 to Feb 28, 2010 (577,981 screening visits).
EXPOSURES: BMI, waist circumference, and percent fat mass.
MAIN OUTCOME MEASURE(S): At each visit, IOP was measured in both eyes with automated noncontact tonometers.
RESULTS: In multivariable-adjusted models, the average increase in IOP (95% confidence intervals) over time per interquartile increase in BMI (1.26 kg/m2), waist circumference (6.20 cm), and percent fat mass (3.40%) were 0.18 mmHg (0.17 to 0.19), 0.27 mmHg (0.26 to 0.29), and 0.10 mmHg (0.09 to 0.11), respectively (all P < 0.001). The association was stronger in men compared to women (P < 0.001) and it was only slightly attenuated after including diabetes and hypertension as potential mediators in the model.
CONCLUSIONS AND RELEVANCE: Increases in adiposity were significantly associated with an increase in IOP in a large cohort of Korean adults attending health screening visits, an association that was stronger for central obesity. Further research is needed to understand better the underlying mechanisms of this association, and to establish the role of weight gain in increasing IOP and the risk of glaucoma and its complications.
METHOD: In this cross-sectional study, 9432 community-dwelling elderly people aged 60 years and older living in rural or urban areas in Haikou were investigated. The interviews collected self-reported information on the presence of four major chronic diseases, as well as socio-demographic characteristics, lifestyle factors and self-reported height and weight.
FINDINGS: Overall, 31.7% (2961/9344) reported at least one of the four chronic diseases. The prevalence of hypertension, diabetes mellitus, COPD, and stroke was 26.0% (2449/9407), 8.0% (749/9371), 1.0% (95/9360), and 1.9% (175/9382), respectively. Common correlates of the four major chronic diseases were older age, being engaged in intellectual work, currently being a smoker and obesity. Gender, locality of residence, and alcohol consumptions were also found to be associated to some of the chronic conditions.
CONCLUSION: This finding indicates that multiple chronic conditions among elderly people in Haikou are prevalent and warrant special attention to reduce diseases burden and align health care services to cater the holistic elderly patients' need.
METHODS AND ANALYSIS: Initially, during Phase I of the study, the serum level of IL-1β, IL-6 and TNF-α; ERP changes in the EEG and fecal microbiota content will be compared between 120 AUD patients and 120 healthy controls. Subsequently in Phase II of the study, 120 AUD patients will be randomized by stratified permuted block randomization into the probiotic, ACT and placebo groups in a 1:1:1 ratio. Participants in the probiotic and placebo groups will be administered one sachet per day of Lactobacillus spp. probiotic and placebo, respectively for 12 weeks. While those in the ACT group will receive one session per week of ACT for 8 weeks. Outcome measures will be administered at four timepoints, such as t0 = baseline assessment prior to intervention, t1 = 8 weeks after intervention began, t2 = 12 weeks after intervention and t3 = 24 weeks after intervention. Primary outcomes are the degrees of alcohol craving, alcohol withdrawal during abstinence and AUD. Secondary outcomes to be assessed are the severity of co-morbid depression and anxiety symptoms; the serum levels of IL-1β, IL-6 and TNF-α; changes in ERP and fecal microbiota content.
TRIAL REGISTRATION NUMBER: NCT05830708 (ClinicalTrials.gov). Registered on April 25, 2023.
METHODS: A cross-sectional study was conducted in Amman, the capital and largest city of Jordan, using a validated questionnaire. It was distributed to pharmacists working in community and hospital pharmacies using a convenience sampling technique. Descriptive and inferential statistics were performed in this study.
RESULTS: A total of 340 questionnaires distributed, 300 (88%) pharmacists responded. Over 50% of pharmacists claimed that they have sufficient knowledge regarding FDI. Virtually, the overall median (interquartile range) knowledge score was 18 (15-21), approximately 60%. The highest knowledge scores were for alcohol-drug interactions section (66.6%) followed by both common food-drug interactions and the timing of drug intake to food consumption sections with a score of (58.3%) for each, reflecting a suboptimal knowledge of FDIs among the pharmacists.
CONCLUSION: Pharmacists had unsatisfactory knowledge about common FDIs, with no significant difference between hospital and community pharmacists. Therefore, more attention and efforts should be played to improve awareness about potential food-drug interactions.
MATERIALS AND METHODS: The OncoCarta(™) panel v1.0 assay was used to characterize oncogenic mutations. In addition, exons 4-11 of the TP53 gene were sequenced. Statistical analyses were conducted to identify associations between mutations and selected clinico-pathological characteristics and risk habits.
RESULTS: Oncogenic mutations were detected in PIK3CA (5.7%) and HRAS (2.4%). Mutations in TP53 were observed in 27.7% (31/112) of the OSCC specimens. Oncogenic mutations were found more frequently in non-smokers (p = 0.049) and TP53 truncating mutations were more common in patients with no risk habits (p = 0.019). Patients with mutations had worse overall survival compared to those with absence of mutations; and patients who harbored DNA binding domain (DBD) and L2/L3/LSH mutations showed a worse survival probability compared to those patients with wild type TP53. The majority of the oncogenic and TP53 mutations were G:C > A:T and A:T > G:C base transitions, regardless of the different risk habits.
CONCLUSION: Hotspot oncogenic mutations which are frequently present in common solid tumors are exceedingly rare in OSCC. Despite differences in risk habit exposure, the mutation frequency of PIK3CA and HRAS in Asian OSCC were similar to that reported in OSCC among Caucasians, whereas TP53 mutations rates were significantly lower. The lack of actionable hotspot mutations argue strongly for the need to comprehensively characterize gene mutations associated with OSCC for the development of new diagnostic and therapeutic tools.