Torque Teno Virus (TTV) is a human-infected virus that is present ubiquitously in nature. Globally, it infects up to 95% of the healthy individuals without any clinical manifestations. The widely used laboratory diagnosis of TTV infection is Polymerase chain reaction (PCR). Nevertheless, several other methods have been developed. The rapid growth of TTV variants over time has posed a challenge in estimating the global TTV infection as none of the PCR protocol has the ability to detect the entire spectrum of TTV variants. Multiple TTV epidemiological studies have been conducted among Asian population, whereas other continents showed a limited number of studies. The horizontal and vertical transmission of TTV among humans population, as well as interspecies transmission are potentially related to the global widespread of TTV infection.
Semiconductor metal oxide (SMO) as a sensing layer for gas detection has been widely used. Many researches have been performed to enhance the sensing performance including its sensitivity, reliability and selectivity. Electrical sensors that use resistivity as an indicator of its sensing are popular and well established. However, the optical based sensor is still much to explore in detecting gas. By integrating it with SMO, the sensor offers good alternative to overcome some drawbacks from electrical sensors.
In the recent decades, lactic acid bacteria (LAB) in aquatic organism have been one of the major interesting research subjects due to their various existence strains in fish microbiota. Moreover, LABs are sometimes abundant in the intestine of several fish species. Many recent papers indicated that several LAB strains are harmless and have been reported for beneficial effects on fish health. There was also converging evidence that led us for more research and findings regarding LAB as a promising probiotics in aquaculture. This article provides an overview of the variability of LAB in gastrointestinal (GI) tract of fish and the development of this species as probiotics. LAB was known able to colonise the gut, and has antagonistic activity against some fish pathogens. This harmless bactreriocin-producing strain may confer benefits in increasing disease resistance, improving nutrient digestibility and growth of the host animals. In addition, these strains may reduce the need of antibiotics usage in future aquaculture industry.
Naturally, plant habitats are exposed to several potential effects of biotic and different abiotic environmental challenges. Several types of micro-organisms namely; bacteria, viruses, fungi, nematodes, mites, insects, mammals and other herbivorous animals are found in large amounts in all ecosystems, which lead to considerable reduction in crop productivity. These organisms are agents carrying different diseases that can damage the plants through the secretion of toxic-microbial poisons that can penetrate in the plant tissues. Toxins are injurious substances that act on plant protoplast to influence disease development. In response to the stress effect, plants defend themselves by bearing some substances such as phytoalexins. Production of phytoalexins is one of the complex mechanisms through which plants exhibit disease resistance. Several findings specifically on phytoalexins have widen the understanding in the fields of plant biochemistry and molecular biology. However, this review reports the interaction of toxins and phytoalexins in plant-pathogen cycle, research progress on the association of phytoalexins with plant disease resistance as well as the role of the phytoalexins in plant disease control.
The purpose of this article is to illustrate the links between the three factors of parental attachment (i.e., communication, trust, and alienation) and cyberbullying experiences among school- going children. A total of 375 students aged 9 to 16 years old were selected using stratified sampling method from 8 schools in Selangor. The authors adapted a 10-item instrument from the previous studies of Youth Internet Safety Survey (YISS) and EUkidsonline scales to assess the cyberbullying prevalence based on two sub-dimensions (online harassment and sex-based bullying). The confirmatory factor analysis (CFA) was used to analyse the construct validity of the scales. Structural equation modelling (SEM) then was used to test the study hypotheses. The final model has an estimated that 10% (R2=.95) of the variance in cyberbullying is explained by parental attachment, indicating only the alienation factor predicted the children’s cyberbullying experiences. The findings, however, supported a differentiated approach to positive parenting.
Waterbirds serve as an important bio-indicator of ecosystem changes and have been used widely throughout the world. This is because they exhibit conspicuous and meaningful responses to the changes of the environment around them. Other qualities that make them a good bio-indicator are also highlighted. Thus, important information on their biology and ecology are essential to make informed decisions. This is crucial in order to better conserve them and their habitats. Currently they are facing new challenges that arise from continuous development throughout the world. In addition, many endangered species continue to declines and could be extinct if they are not protected and conserved. The development of artificial habitat such as wetlands to compensate natural habitat loss could be an alternative. However, detailed information on the waterbirds and their interactions with the new environment are needed in order to do so. It is further highlighted that few researches have been conducted and focused on the waterbirds particularly in Malaysia. Thus, we encourage more local young scientists to take up this challenge and equip themselves with the right knowledge and necessary skills as well as to remain relevant with the international research standards. Proper planning, funding and focus should also be considered by the government and local authorities to maximize the impact of the country’s conservation effort.
Psychological health as one of the most crucial indicators of successful adolescents has received considerable attention in the literature. High prevalence rates of various psychological problems amongst adolescents emphasize the significance of identifying paternal parenting behaviour that may reduce the risk of these problems. However, little attention has been given to how fathers influence their adolescents’ psychological health, especially in an Asian context. To address this issue, this paper presents a thorough discussion of past literature related to paternal parenting behaviour and psychological health of adolescents. The discussion begins with a review related to psychological health, paternal parenting behaviour, and followed by the relationships between paternal parenting behaviour and psychological health. Based on the review of the literature, several research gaps will be addressed at the end of this paper.
Commercialisation of glyphosate [N-(phosphonomethyl)glycine] in the early 1970s has left a big leap in the agriculture sector. This is due to its effectiveness in controlling a wide range of weeds. Glyphosate translocates well in plants. In addition, with added surfactant in its formulae, it can also be used in wet conditions. Its ability to kill weeds by targeting the 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSPS) makes no competing herbicide analogs in its class. Considering its cost effectiveness, only small amount is needed to cover a large sector in agricultural land. The most important aspect in the success of glyphosate is the introduction of transgenic, glyphosate-resistant crops in 1996. However, glyphosate is not an environmental friendly herbicide. This systematic herbicide has raised environmental concern due to its excessive use in agriculture. Studies have shown traces of glyphosate found in drinking water. Meanwhile, it's rapid binding on soil particles possesses adverse effect to soil organisms. Glyphosate degradation in soil usually carried out by microbial activity. Microbes’ capable utilising glyphosate mainly as phosphate source. However, the activity of C-P lyase in breaking down glyphosate have not clearly understood. This review presents a collective summary on the understanding on how glyphosate works and its environmental fate.
It is hard to identify the local Malay identity in a design context compared to other cultural oriented design in several countries. This paper tries to uncover how designers interpret local identity embodied agent based on local items influences and understood and the influence of incremental, radical design that changes respective to preceding designs. A descriptive study through the literature reviews focusses on a type of artefact initiated through cultural-oriented design. Based on the preliminary study, a sampling taken from the Chinese, Indian, Japanese or European consistently apply the same fundamental understanding in regards to the culture-oriented design. From the same point of view, teapot seems to be used as one of the dominant artefact indicating the design preferences. This research will benefit both the academia and the industry and identify significant identity based on the local context and become an embodied agent to give impact in establishing the state-of-the-art of brand, the identity of local design, establish new trademark towards generating domestic, international economy and promote the nation worldwide throughout design platform.
Ki-67 expression is strongly correlated with tumour cell proliferation and growth. It is widely used as a proliferation marker in the routine pathological investigation. The nuclear protein Ki- 67 (pKi67) is recognised prognostic and predictive indicator for the biopsies assessment for cancer patients. Clinically, pKi67 has been revealed to associate with metastasis and the clinical stage of tumours. Furthermore, it has been presented that the expression of Ki-67 is significantly higher in malignant tissues with poorly differentiated tumour cells, as compared with normal tissue. The Ki-67 labelling index plays a vital role as an independent prognostic factor for survival rate, which includes all stages and grade categories. There is an association between the ratios of Ki-67 positive malignant cells and patient survival. This review provides an overview of recent advances in detecting Ki-67 in ovarian carcinoma.
Substance abuse is an epidemic that spreads among adults, adolescents and even children in Malaysia. Substance abuse is categorized as a mental disorder, whereby, Cognitive Behavioural Therapy (CBT) is an approach that provides face to face physiological therapy for patients could resolve this issue. Computerized Cognitive Behavioural Therapy (CCBT) is a progression of information technology that is provided for patients encounter substance abuse. CCBT is a computerized therapy conducted at patient’s own pace. Ensuring patient’s continuous engagement towards CCBT becomes an issue. Patients that experience early gains, loss of interest and improvement symptom would sign up for alternative services that eventually causes disengagement and dropout from CCBT program. Interface design for CCBT is known as one of the important elements that effects patient’s engagement along CCBT program. Therefore, in this study, influential factors regarding CCBT’s interface design was investigated, whereby, five prominent models was reviewed. Content analysis methodology was employed to discover influential factors regarding CCBT’s interface design. Four influential factors was discovered namely engagement, dropout, culture and interface. These factors are known to ensure patient’s continuous engagement towards CCBT program. CCBT’s interface design plays a vital role in delivering the therapy program. Indirectly, CCBT’s interface design plays an important role to ensure patient’s continuous engagement till the completion of CCBT program. Therefore, these factors would guide researcher, service provider, developers and clinicians in designing engaging interface for CCBT.
Zakah is an Islamic financial instrument anchored within the Islamic economic system. Its establishment is to reduce inequalities within the Muslim community so that fair and social justice would be attained. In Malaysia, the administration of all religious matters including zakah is under the auspice of State Islamic Religious Council (SIRC). There are 14 states in Malaysia, and every state has its SIRC. As a religious and zakah agent, the institution is entrusted to govern zakah funds so that the beneficiary’s living standard could be transformed to a higher level. This paper conceptually reviews the role of zakah institution in governing and transforming the beneficiary’s living standard from daruriyyat (dire necessities) to higher level that is hajiyyat (comfort living) in relation to Maqasid al Syariah. As to ensure the success of the transformation, zakah institution should play proactive roles and be optimistic in formulating and initiating potential programmes that would generate income and make the beneficiary wealthy. Hence, the objective of Maqasid al Syariah under zakah jurisprudence will be achieved, if zakah funds are channelled to productive programs that would transform the beneficiary’s living standard and eventually free him/her from the shackles of poverty.
Ergogenic aids usage by athletes is a common scenario that can be seen in any level of athletes and any types of sports nowadays. Ergogenic aids can range from drugs, food, hormone, mechanical aid and herbs. Traditionally, ergogenic aids can be classified into categories namely: physiological, psychological, mechanical, pharmacological and nutrition. Despite all these classification, all ergogenic aids had one common purpose, which is to improve physical performance. Herbs consumption as ergogenic aids had been practiced since years ago by athletes as either nutritional or pharmacological aids. Using herbs as physical performance booster has gained popularity since it was claimed safer and natural. One of local herb that gets attention as energy booster is Ficus deltoidea (Mas Cotek). Ficus deltoidea had been used traditionally to restore energy. Few studies had reveal that Ficus deltoidea had medicinal properties such anti-nociceptive, antioxidant, wound healing enhancer and blood glucose regulation properties. There is no direct study on Ficus deltoidea as energy booster or ergogenic aids, but this medicinal value might be beneficial to increase athlete’s physical performance. Ergogenic aids, especially those that been produce using herbs, rarely have scientific evidence to determine its effectiveness, safety, dosage and mechanism of action. Ergogenic aids were normally marketed with claims and report as their reference, not scientific evidence. The most frequent claim used by traders is that ergogenic aids can increase and sustain body’s energy. This review will discuss on how ergogenic aids might help athletes to increase their physical performance and possibility of using Ficus deltoidea as ergogenic aids based on its medicinal properties.
The demand of fruits and vegetables across the world had increased throughout the years which urge the need to have better and proper way to increase produce safety, quality and postharvest life. Traditionally pesticides or other chemicals had been used to encounter microbes related to postharvest diseases. Over time, consumers are concern towards health effect of consuming those produce treated with chemicals. Ozone is one of the approach that provide both of the needs to deal with pathogenic microbes and also give no harmful residue throughout the process. Several reports had proven that ozone can almost kill or inhibit all pathogenic microbes on treated commodity which promote higher quality and postharvest life during storage. This review focus and summarise the use of ozone in the form of aqueous and gaseous towards fresh produces, its benefits and also the precaution during ozone application.
This paper discusses the three most prevalent elements of Islamic art that a r e embedded in modern furniture. This study is isolated from three design thinking approaches. A comparative study has been executed between three most apparent elements of Islamic art, which are arabesque, geometric and calligraphy. Those three types of design are applicable and relevant to modern furniture design nowadays. Therefore, the Islamic model was the paradigm in defining the furniture design character. The unstructured parameter within the appropriate method is a significant way of collecting the findings and usually used in the area of furniture design. The main results of this study are on how Islamic pattern is linked with the artistic design elements. The outcome of this investigation also contributes to a significant tendency in contemporary furniture design thinking solutions. Finally, this paper ends with discussions from three types of design thinking, which is the normative, reflective and hermeneutic design that collaborates with the current modern furniture design.
Living in today's era, artists’ practice in creating artwork is different from those practiced 20 years ago. With the existence of digital art followed by electronic art in the local art scene, the presentation, style and approach have evolved. Back in 2005 and 2007, some exhibitions brought hybrid art concept into an art exhibition. One of the shows was ‘Hybrid+ism’ which highlighted in various disciplines, media, applying unlimited processes and medium. The purpose of this paper is to study the artists’ practice in the hybrid art based on selected artworks. The artworks are selected based on some criteria ranging from experimental, mixed media, multi-disciplines, integration and technology as well as culture aspects. This paper is discussing the hybrid art practice among artists in the Malaysian art scene and the challenges to creating awareness on hybrid practice among audiences.
Red seaweeds (Rhodophyta) produce a variety of sulfated galactans in their cell wall matrix and intercellular space, contributing up to 50-60 % of their total dry weight. These sulfated polysaccharides are made up of galactose disaccharides substituted with sulfate, methoxyl, pyruvic acid, or non-galactose monosaccharides (e.g. xylose, glucose and mannose). They are required by the Rhodophytes for protection against pathogen, desiccation, tidal waves and extreme changes in pH, temperature and salinity. Since ancient times, sulfated galactans from red seaweeds, such as agar and carrageenan, have been consumed as human foods and later being used in traditional medicine. Nowadays, some red seaweeds are cultivated and exploited for commercial uses in various fields. In this review, different types of sulfated galactans found in red seaweeds and their current and potential uses in food, biotechnology, medical and pharmaceutical industries are discussed.
Hospitals have a complex environment setting which may cause confusion amongst visitors and the tendency of them getting lost is possibly high. This article aims to highlight the wayfinding aids used by visitors in hospitals. However, there are barriers and challenges that may affect the success of wayfinding experience amongst hospital visitors. Three targeted factors, namely poor and unfriendly signage; inconsistent utilisation of the numbering system; and difficulty in navigating the hospital premise have been identified to be improved. Therefore, by incorporating these factors with a constant stimuli method with fixed images in an indoor public hospital environment, this may improve visitors’ experiences when navigating in a hospital.
Unemployment and poverty are seriously issue of concern globally, especially in developing countries like Nigeria. Unemployment and poverty among university graduates in Nigeria, the trends on rising every year, major corporations are cutting down jobs and graduates who were interested to work can’t seem to find a job. However, entrepreneurship and business formation have been recognised around the World as a remedy for unemployment and pivotal for economies to grow. Therefore, promotion of entrepreneurial activity becomes the most top priority on the government agenda. Despite the unique role played by entrepreneurship to the economy as a whole and to the person that established business, in Nigeria, the rate of university graduates in entrepreneurship is far below expected. This led to many research efforts on factors that are having an effect on student’s entrepreneurial intentions. This review paper proposed the intention to be an entrepreneur can be explained by Ajzen, (1991) theory of planned behaviour, institutional, and core self-evaluation theories. Psychological (self-efficacy, risk-taking propensity, locus of control, innovativeness, need for achievement) and institutional (university environment, government support programmes) factors will have an effect on attitudes, subjective norms, perceived behavioural control. Consequently, the study predicted the entrepreneurial intentions of the Nigerian university students.
Cervical cancer is one of the leading causal cancer-related fatalities in the world. Cervical cancer patients can be treated by conventional treatment such as surgery, radiotherapy, chemotherapy, medications and combination treatments. Currently, more targeted treatments are being developed to cure cervical cancer. The treatments include immunotherapy, virotherapy and gene therapy which will be discussed in this paper. In immunotherapy, the synergy of CTLA-4 suppression and PD-1/PDL-1 immune checkpoint inhibition targeting their corresponding pathways enhanced the human immune system resulting a promising treatment effects. Oncolytic viruses such as Newcastle disease virus selectively infect and kill cancerous cells/tissues without harming normal cells/tissues. This character has made them a potential modality in combating cancer which popularly known as oncolytic virotherapy. Gene therapy delivers modified genetic materials to the target cancer cells via viral and non-viral vectors. It is used to target the abnormal gene, to increase cells’ susceptibility towards drugs or conventional therapy, to induce tumour cells apoptosis, to enhance tumour cell immunogenicity recognition and to inhibit the oncogene expression. The objective of this minireview is to add to the general knowledge on aforementioned therapeutic strategies against cervical cancer.