Displaying publications 81 - 100 of 157 in total

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  1. Siddiqui MJ, Saleh MSM, Basharuddin SNBB, Zamri SHB, Mohd Najib MHB, Che Ibrahim MZB, et al.
    J Pharm Bioallied Sci, 2018 12 21;10(4):173-180.
    PMID: 30568374 DOI: 10.4103/JPBS.JPBS_83_18
    Saffron, Crocus sativus (Iridaceae), is a perennial herb, which earned its popularity as both medicine and spice. It is an inhabitant of different mountainous regions of Asia Minor to Greece, Western Asia, Egypt, and India. The benefits of saffron as an antidepressant are well-documented. Almost 150 volatile and nonvolatile compounds are obtained from the chemical analysis of this plant. Fewer than 50 constituents elucidated and identified so far showed phytochemical characteristics. The major bioactive compounds identified are safranal, crocin, and picrocrocin, which are responsible for its aroma as well as its bitter taste. This review is an attempt to encompass the methods of analysis and pharmacodynamic and pharmacokinetic properties of saffron followed by its efficacious and safe potential.
  2. Perti S, Mansuri S, Pilli J, Kaur A, Alwithanani N, Kondreddy K
    J Pharm Bioallied Sci, 2023 Jul;15(Suppl 1):S187-S191.
    PMID: 37654361 DOI: 10.4103/jpbs.jpbs_450_22
    INTRODUCTION: Recurrent abutment substitutions may physically irritate the mucosal (soft tissue) barrier, which may cause additional toxic irritants and germs to enter the mucosal implant barrier and weaken the tissues surrounding implant. The creation of a "definitive abutment" may lessen the likelihood of tissue losses around the implant. Determining the characters of the peri-implant tissue after the placement of the definitive abutments and multiple abutment replacement was the goal of this study.

    MATERIALS AND PROCEDURES: Forty missing teeth were replaced with implants in matched subjects. Parameters assessed were "distance of cement enamel junction to alveolar crest and distance of CEJ to gingival margin; bleeding on probing, Sulcus probing depth, and peri-implant marginal bone loss." Subjects were randomly assigned for the two groups of intervention. All the measurements were documented at designated timelines and compared for the statistical variance where P < 0.05 was considered as significant.

    RESULTS: In the control and test groups, the peri-implant marginal bone level rose from baseline to 3 months. There were no appreciable differences between the CEJ-AC and CEJ-GM groups when the clinical and radiographic parameters of each group were evaluated. Throughout all of the time points, the soft tissue borders in both groups remained comparably steady.

    CONCLUSION: The study's findings suggest that using implants with definite abutments is more advantageous for obtaining better maintenance in terms of the health of the tissues that surround the implants.

  3. Karpathak S, Mansuri S, Dev SV, Pilli J, Alwithanani N, Kondreddy K
    J Pharm Bioallied Sci, 2023 Jul;15(Suppl 1):S183-S186.
    PMID: 37654403 DOI: 10.4103/jpbs.jpbs_449_22
    INTRODUCTION: In many oral procedures that involve the implants, hair implantations, "Platelet-Rich Fibrin Membrane (PRF)" is commonly applied. The advantages are many. In this study, the mechanical resistance of PRF under resistance pull on a longitudinal axis was assessed and compared.

    MATERIAL AND METHODS: For the current in vitro study, 60 volunteers donated each 10 ml of their blood and hence a total volume of 600 ml of blood was procured that was analyzed for the current study. The total volume was grouped to three groups where they receive three resistance centrifugation forces of "F-200,600,800 m/s²." In each group, 20 samples were tested for each level of the G-resistance. Each group was further divided as two subgroups of different times of wait, where they were centrifuged at baseline time and after a stand of 30 minutes. On universal testing equipment, the PRF membranes were mechanically tensioned in order to determine each membrane's resistance force. These values were compared for any statistical variance using appropriate statistical tools keeping P < 0.05.

    RESULTS: Any applied force had no statistically significant effect on the centrifugation duration for membrane resistance. When the resistance was applied for the PRP samples immediately after they were procured, no significant variation was seen at all the grades of the centrifugation forces; consequently, the T30 group showed a statistically significant variance for the centrifugation forces applied (P = 0.04), with the highest value when the greatest force was applied. According to the results, the centrifugation waiting period could be determined based on the application requirement.

    CONCLUSION: For immediate membrane usage, the centrifugation had no effect on resistance; however, after 30 minutes, a membrane with greater resistance was produced by applying more force.

  4. Majeed R, Sathi KV, Patil RS, Singh N, Duseja S, Kondreddy K
    J Pharm Bioallied Sci, 2024 Feb;16(Suppl 1):S215-S218.
    PMID: 38595612 DOI: 10.4103/jpbs.jpbs_464_23
    Antidepressants have anti-inflammatory effects and boost immunity, and dentists should be aware. This case-control study included only those patients who consented to take part and had a ham-d score of at least 16 and a diagnosis of moderate-to-severe depression. Inclusion criteria included adults, those experiencing moderate to severe depression, taking fluoxetine or venlafaxine, and those with twenty or more teeth. Exclusion criteria included tobacco chewers, smokers, women expecting or nursing, periodontal treatment, antibiotics, anti-inflammatory medication, or vitamin/nutritional supplements. Patients who had had surgery or other therapy were excluded from the study. Three groups of patients were created: Control, venlafaxine, and fluoxetine. A periodontist assisted in the dental examination, and indices were observed. The analysis was done using Statistical Package for the Social Sciences (SPSS) version 24.0. Number, percentage, mean, and standard deviation were used to present the values. Results showed that antidepressants may be a risk factor for periodontal health, with increased periodontal parameters, and concluded that It is crucial to frequently check the periodontal health of depressed people using fluoxetine or venlafaxine since these drugs put good periodontal tissues at risk.
  5. Kannaiyan K, Prasad V, Chander VB, Avinash R, Kouser A
    J Pharm Bioallied Sci, 2021 Nov;13(Suppl 2):S1737-S1740.
    PMID: 35018066 DOI: 10.4103/jpbs.jpbs_288_21
    Congenitally missing anterior teeth alters the patient's physiognomy and diction in a big way. Maxillary incisor agenesis, prominently the lateral incisor is the most common congenitally missing permanent tooth, in the anterior maxillary region, which is the esthetic zone, representing approximately 20% of all dental anomalies. Treatment planning is inclusive of; smile design, preparation, perception of the patients, and their expectations in relation to esthetics, interdisciplinary alliance that meets the functional, health, and esthetic needs. A critical factor for the overall success is that of choosing a suitable restorative recourse. The case report describes the esthetic rehabilitation for congenitally missing maxillary lateral incisor and early traumatic loss of central incisor using an all ceramic-fixed prosthesis.
  6. Trivedi K, Bhaskar V, Ganesh M, Venkataraghavan K, Choudhary P, Shah S, et al.
    J Pharm Bioallied Sci, 2015 Aug;7(Suppl 2):S474-80.
    PMID: 26538901 DOI: 10.4103/0975-7406.163508
    AIM: This study evaluates erosive potential of commonly used beverages, medicated syrup, and their effects on dental enamel with and without restoration in vitro.

    MATERIALS AND METHODS: Test medias used in this study included carbonated beverage, noncarbonated beverage, high-energy sports drink medicated cough syrup, distilled water as the control. A total of 110 previously extracted human premolar teeth were selected for the study. Teeth were randomly divided into two groups. Test specimens were randomly distributed to five beverages groups and comprised 12 specimens per group. Surface roughness (profilometer) readings were performed at baseline and again, following immersion for 14 days (24 h/day). Microleakage was evaluated. The results obtained were analyzed for statistical significance using SPSS-PC package using the multiple factor ANOVA at a significance level of P < 0.05. Paired t-test, Friedman test ranks, and Wilcoxon signed ranks test.

    RESULTS: For surface roughness high-energy sports drink and noncarbonated beverage showed the highly significant difference with P values of 0.000 and 0.000, respectively compared to other test media. For microleakage high-energy sports drink had significant difference in comparison to noncarbonated beverage (P = 0.002), medicated syrup (P = 0.000), and distilled water (P = 0.000).

    CONCLUSION: High-energy sports drink showed highest surface roughness value and microleakage score among all test media and thus greater erosive potential to enamel while medicated syrup showed least surface roughness value and microleakage among all test media.

  7. Kannaiyan K, Biradar Sharashchandra M, Kattimani S, Devi M, Vengal Rao B, Kumar Chinna S
    J Pharm Bioallied Sci, 2020 Aug;12(Suppl 1):S399-S403.
    PMID: 33149494 DOI: 10.4103/jpbs.JPBS_117_20
    Introduction: Polymethyl methacrylate (PMMA) has been widely accepted and used in dentistry owing to its working characteristics, aesthetics and stability in the oral environment, ease in manipulation, and inexpensive processing methods and equipment.

    Aim and Objectives: The aim of this study was to evaluate the flexural strength of a high-impact PMMA denture base resin material and flexural strength of a commonly available heat cure PMMA denture base material with Kevlar, glass, and nylon fibers.

    Materials and Methods: The test samples were studied under two groups. The Group I (control group) comprised pre-reinforced PMMA (Lucitone 199; Dentsply Sirona Prosthetics, York, Pennsylvania, USA) consisting of 12 samples and second group comprised regular PMMA (DPI, Mumbai, India) reinforced with different fibers. The second test group was further divided into three subgroups as Group 2, Group 3, and Group 4 comprising 12 samples each designated by the letters a-l. All the samples were marked on both ends. A total of 48 samples were tested. Results were analyzed and any P value ≤0.05 was considered as statistically significant (t test).

    Results: All the 48 specimens were subjected to a 3-point bending test on a universal testing machine (MultiTest 10-i, Sterling, VA, USA) at a cross-head rate of 2 mm/min. A load was applied on each specimen by a centrally located rod until fracture occurred; span length taken was 50 mm. Flexural strength was then calculated.

    Conclusion: Reinforcement of conventional denture base resin with nylon and glass fibers showed statistical significance in the flexural strength values when compared to unreinforced high impact of denture base resin.

  8. Jaiswal D, Kalia P, Hiremath S, Singh AK, Pani P, Kumar N
    J Pharm Bioallied Sci, 2021 Jun;13(Suppl 1):S112-S115.
    PMID: 34447056 DOI: 10.4103/jpbs.JPBS_590_20
    Background: Oral diseases such as dental caries, gingivitis, and periodontitis are common among population. The present study was conducted to assess dental caries status and oral hygiene practice among school children.

    Materials and Methods: This school-based study was conducted on 520 children of age group of 12-14 years of both genders. Location, education, and employment status of parents, use of toothbrush, frequency of brushing, dental floss, total number of meals in a day, number of snacks between meals and sugar consumption, and decayed, missing, filled teeth were recorded.

    Results: There were 266 males and 254 females. Age group 12 years had 80 males and 90 females, 13 years had 70 males and 60 females, and 14 years had 116 males and 104 females. Ninety-six males and 110 females were from urban and 170 males and 144 females were from rural. The mean plaque score in 12-year male children was 0.61 ± 0.32, in 13-year children was 0.68 ± 0.45, and in 14 years was 0.74 ± 0.48. In males, the mean plaque score was 0.70 ± 0.38 and in females was 0.66 ± 0.42. In children from urban area, the mean plaque score was 0.62 ± 0.34 and from rural area was 0.74 ± 0.40. Four hundred and eighteen children were using toothpaste and they had plaque score of 0.76 and 102 children were using floss and they had plaque score of 0.89. Three hundred and twenty children were brushing once, 90 twice, and 110 irregular and there mean plaque score was 0.70, 0.61, and 0.76, respectively. The difference was significant (P < 0.05).

    Conclusion: Authors found that oral health status of children consuming high sugar, more snacks per day, and brushing occasionally was poor.

  9. Ramesh M, Malathi N, Ramesh K, Aruna RM, Kuruvilla S
    J Pharm Bioallied Sci, 2017 Nov;9(Suppl 1):S88-S91.
    PMID: 29284943 DOI: 10.4103/jpbs.JPBS_77_17
    Background: High levels of fluoride in the drinking water, especially ground water, results in skeletal fluorosis which involves the bone and major joints. This study was conducted to assess the prevalence of skeletal fluorosis to compare with dental fluorosis in an endemically fluorosed population in the District of Salem, Tamil Nadu.

    Materials and Methods: Institutional ethical clearance was obtained. A total of 206 patients who reported to the Department of Hematology for blood investigations were the participants in this study. Age, sex, place, weight, height, dental fluorosis, and skeletal complaints were noted down. Body mass index was calculated, and statistical analysis was performed.

    Results: Dental fluorosis was present in 63.1% and absent in 36.9% of the samples reported. Skeletal fluorosis was present in 24.8% and was absent in 75.2%. A large number of the patients had knee pain and difficulty in bending. Chi-square test was used for statistical analysis. Skeletal fluorosis and age were compared and P value was 0.00 and was significant. Dental fluorosis and skeletal fluorosis were compared and P value was found to be 0.000 and significant.

    Discussion and Conclusion: There is a need to take measures to prevent dental and skeletal fluorosis among the residents of Salem district. Calcium balance should be maintained, and fluoride intake should be minimized to reduce the symptoms. The government should provide water with low fluoride level for drinking and cooking. Once the symptoms develop, treatment largely remains symptomatic, using analgesics and physiotherapy.

  10. Dua K, Pabreja K, Ramana MV, Lather V
    J Pharm Bioallied Sci, 2011 Jul;3(3):417-25.
    PMID: 21966164 DOI: 10.4103/0975-7406.84457
    The objective of the present investigation was to study the effect of β-cyclodextrin (β-CD) on the in vitro dissolution of aceclofenac (AF) from molecular inclusion complexes. Aceclofenac molecular inclusion complexes in 1:1 and 1:2 M ratio were prepared using a kneading method. The in vitro dissolution of pure drug, physical mixtures, and cyclodextrin inclusion complexes was carried out. Molecular inclusion complexes of AF with β-CD showed a considerable increase in the dissolution rate in comparison with the physical mixture and pure drug in 0.1 N HCl, pH 1.2, and phosphate buffer, pH 7.4. Inclusion complexes with a 1:2 M ratio showed the maximum dissolution rate in comparison to other ratios. Fourier transform infrared spectroscopy and differential scanning calorimetry studies indicated no interaction between AF and β-CD in complexes in solid state. Molecular modeling results indicated the relative energetic stability of the β-CD dimer-AF complex as compared to β-CD monomer-AF. Dissolution enhancement was attributed to the formation of water soluble inclusion complexes with β-CD. The in vitro release from all the formulations was best described by first-order kinetics (R(2) = 0.9826 and 0.9938 in 0.1 N HCl and phosphate buffer, respectively) followed by the Higuchi release model (R(2) = 0.9542 and 0.9686 in 0.1 N HCl and phosphate buffer, respectively). In conclusion, the dissolution of AF can be enhanced by the use of a hydrophilic carrier like β-CD.
  11. Farsalinos KE, Le Houezec J
    J Pharm Bioallied Sci, 2016;8(4):347-348.
    PMID: 28216962 DOI: 10.4103/0975-7406.199341
    Comment on: Elkalmi RM, Bhagavathul AS, Ya’u A, Al-Dubai SA, Elsayed TM, Ahmad A, et al. Familiarity, perception, and reasons for electronic-cigarette experimentation among the general public in Malaysia: Preliminary insight. J Pharm Bioallied Sci. 2016;8:240–7
  12. Hamid N, Muhamad R, Kueh YC, Zahari Z, Mohamad Nor N, Abdullah N, et al.
    J Pharm Bioallied Sci, 2020 10 08;12(4):444-448.
    PMID: 33679091 DOI: 10.4103/jpbs.JPBS_265_19
    Background: In Malaysia, the problem of marital distress is fast becoming an important public health concern. A major shortcoming is inadequate marital evaluation. There are, however, very few localized instruments for married women in Malaysia. The objective of this study was to translate the original version of the Revised Dyadic Adjustment Scale (RDAS) and to evaluate for its psychometric properties. Multiple aspects of validity and reliability were also assessed.

    Materials and Methods: The questionnaire was first translated into the Malay language (RDAS-M). In this cross-sectional study, healthy married Malay women in Kota Bharu, Kelantan, were recruited from January to April 2018. Participants were asked to complete the RDAS-M that consists of three domains, that is, dyadic consensus, dyadic satisfaction, and dyadic cohesion with a total of 14 items. The concept, content, and construct validity using exploratory factor analysis (EFA) and reliability of the RDAS-M were assessed.

    Results: Of the 164 recruited participants, 150 consented to participate. The mean age of the participants was 34.1 years (standard deviation [SD], 9.5 years), ranging from 20 to 57 years. All 14 items were considered comprehensible by more than 95% of the subjects. Based on EFA, total variance extracted was 69.08%, and the original three factors were retained. The Malay version of the RDAS was valid based on factor loadings for dyadic consensus, dyadic satisfaction, and dyadic cohesion, which ranged from 0.64 to 0.80, 0.79 to 0.98, and 0.37 to 0.78, respectively. The internal consistency was good with coefficient α of 0.87 for dyadic consensus, 0.93 for dyadic satisfaction, and 0.78 for dyadic cohesion.

    Conclusions: The Malay version of the RDAS is easy to understand, and is a reliable and valid instrument for married women. It is also comparable with the original version of the RDAS in terms of structure and psychometric properties.

  13. Alwan IA, Awadh AI, Tangiisuran B, Khan HRM, Yahaya N, Majid MI
    J Pharm Bioallied Sci, 2020 10 08;12(4):475-481.
    PMID: 33679096 DOI: 10.4103/jpbs.JPBS_340_19
    Background and Purpose: The wide availability of medications has led to an increased exposure of humans to the possibility of poisoning. An unavoidable effect due to the availability of these medications has also led to a rising increment in the number of poisoning cases. All drugs, especially when administered in large doses or overextended periods, can initiate a toxic condition. Therefore, the objective of this study was to examine nationwide, the patterns attributed to poisoning, and to describe the sociodemographic, and geographic distribution of poisoning, by identifying the category of substances implicated in these cases.

    Data Sources and Methods: A retrospective study based on telephone calls reported on poisoning caused by pharmaceutical products undertaken by the National Poisoning Centre (NPC) in Penang (Malaysia) was used as the basis of this study covering the period between 2010 and 2015. The study included the mode and type of poisoning, exposure routes as well as the incidence locations.

    Results: A total of 10,998 cases were examined, finding that females represented 5,899 cases (53.6%) being intoxicated more frequently compared to the number of males, 3,839 (34.9%). The age group of poisoning cases ranged between 20 and 29 years representing 2,579 (23.4%) of reported cases. The common mode of poisoning was attributed to suicide 5,203 (47.3%) from among the 10,998 cases and the highest poisoning agents reported were from the psychiatric group of pharmaceutical products of 2,287 (21%).

    Conclusion and Implications: These findings indicate a rising trend of suicidal poisoning attempts between 2013 and 2015, which emphasizes the need for more stringent and effective enforcement protocols to limit the rising incidence of poisoning. As such, analyzing the trends in poisoning in a particular zone periodically could help health policy-makers to develop management policies and prevention strategies.

  14. Sarangarajan R, Vaishnavi Vedam VK, Sivadas G, Sarangarajan A, Meera S
    J Pharm Bioallied Sci, 2015 Aug;7(Suppl 2):S420-3.
    PMID: 26538890 DOI: 10.4103/0975-7406.163474
    Oral ulcers are a common symptom in clinical practice. Among various causative factors, different types of ulcers in oral cavity exist. Among this, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) appears to be quite neglected by the clinicians due to the limited knowledge and awareness. On reviewing with a detailed approach to titles and abstracts of articles eliminating duplicates, 40 relevant articles were considered. Randomized studies, review articles, case reports and abstracts were included while conference papers and posters were excluded. Of importance, TUGSE cases been reported only to a minimal extent in the literature. Lack of its awareness tends to lead clinicians to a misconception of cancer. Thus, this particular lesion needs to be differentiated from other malignant lesions to provide a proper mode of treatment. The present article reviews various aspects of the TUGSE with emphasis on the clinical manifestation, pathogenesis, histological, and immunohistochemical study. This study provides the clinician contemporaries, a humble expansion to their knowledge of the disease, based on the searched literature, enabling a more comprehensive management of this rare occurrence.
  15. Ramatillah DL, Syed Sulaiman SA, Khan AH, Meng OL
    J Pharm Bioallied Sci, 2017 Oct-Dec;9(4):229-238.
    PMID: 29456373 DOI: 10.4103/jpbs.JPBS_191_17
    Background: Quality of life is one of the parameters to check the improvement of hemodialysis treatment among hemodialysed patients. Those patients will be dealing with this treatment in long term if this treatment is the only way for them to replace their kidney function and this thing will affect their quality of life.
    Objective: To evaluate the quality of life patients on hemodialysis using kidney disease quality of life-short term 24 (KDQoL-SF24) Malaysian Version.
    Materials and Methods: Cohort observational study was conducted in this study. The study included 78 hemodialysed patients in HD center Penang, Malaysia.
    Results: There were 9 components which had the lower of the mean and standard deviation (SD) than the standard form; work status (15.01 ± 35.57), cognitive function (75.66 ± 13.75), quality of life social interaction (76.32 ± 16.11), sleep (55.86 ± 15.30), social support (59.61 ± 22.08), patient satisfaction (43.24 ± 15.32), physical functioning (50.06 ± 42.81), general health (29.62 ± 25.56), and role emotional (54.27 ± 49.92). In this HD center, the group of patient's age who had the lower mean ± SD from the KDQoL-SF Manual Standard were the first and the sixth groups of patient's age (≤20 and 61-70).
    Conclusion: The study conducted in HD center, Penang, Malaysia showed that the scoring of work status, cognitive function, quality of social interaction, sleep, social support, patient satisfaction, physical functioning, general health, and role emotional were low than standard form.
  16. Abu Bakar NA, Sulaiman MR, Lajis N, Akhtar MN, Mohamad AS
    J Pharm Bioallied Sci, 2020 Nov;12(Suppl 2):S711-S717.
    PMID: 33828366 DOI: 10.4103/jpbs.JPBS_344_19
    Introduction: Pain is a major global health issue, where its pharmacotherapy prompts unwanted side effects; hence, the development of effective alternative compounds from natural derivatives with lesser side effects is clinically needed. Chalcone; the precursors of flavonoid, and its derivatives have been widely investigated due to its pharmacological properties.

    Objective: This study addressed the therapeutic effect of 3-(2,5-dimethoxyphenyl)-1-(5-methyl furan-2-yl) prop-2-en-1-one (DMPF-1); synthetic chalcone derivative, on antinociceptive activity in vivo.

    Materials and Methods: The antinociceptive profile was evaluated using acetic-acid-induced abdominal writhing, hot plate, and formalin-induced paw licking test. Capsaicin, phorbol 12-myristate 12 acetate (PMA), and glutamate-induced paw licking test were carried out to evaluate their potential effects toward different targets.

    Results: It was shown that the doses of 0.1, 0.5, 1, and 5 mg/kg of DMPF-1 given via intraperitoneal injection showed significant reduction in writhing responses and increased the latency time in hot-plate test where reduced time spent on licking the injected paw in formalin and dose contingency inhibition was observed. The similar results were observed in capsaicin, PMA, and glutamate-induced paw licking test. In addition, the challenge with nonselective opioid receptor antagonist (naloxone) aimed to evaluate the involvement of the opioidergic system, which showed no reversion in analgesic profile in formalin and hot-plate test.

    Conclusion: Collectively, this study showed that DMPF-1 markedly inhibits both peripheral and central nociception through the mechanism involving an interaction with vanilloid and glutamatergic system regardless of the activation of the opioidergic system.

  17. Elkalmi RM, Bhagavathul AS, Ya'u A, Al-Dubai SA, Elsayed TM, Ahmad A, et al.
    J Pharm Bioallied Sci, 2016 Jul-Sep;8(3):240-7.
    PMID: 27413354 DOI: 10.4103/0975-7406.180768
    OBJECTIVES: The objectives of this study were to assess the general public views and familiarity toward electronic cigarette (e-cigarette) in Kuantan, Malaysia.
    METHODOLOGY: A total of 277 Kuantan people were involved in this study. The questionnaire was distributed at random in shops, businesses, and public places in Kuantan. Statistical analysis was performed using SPSS (version 17.0).
    RESULTS: From 400 participants, a total number of 277 (160, 57.7% men and 117, 42.4% women) respondents completed the questionnaire. The mean age was 26.89 ± 9.8 years old. The majority of the study participants were male (57.7%), Malay (83.8%), Muslims (83.8%), singles (69%), and employed (75.8%), with about 83 (29.9%) of the respondents were smokers. The prevalence of e-cigarettes smokers was found to be only 1.4% (n = 4). About one-third of the respondents (n = 72, 26%) have tried e-cigarette before. Job status was significantly associated with smoking e-cigarette among the population (P = 0.02). Main factors for a person to start e-cigarette smoking were curiosity (37.5%) and cheaper price (40.8%). Majority of respondents agreed that e-cigarette would not affect health as normal cigarette, and that variety of flavors contribute to better enjoyment (51.6% and 66.7%, respectively).
    CONCLUSION: The results of the current study demonstrate that the prevalence of e-cigarettes smoking and its popularity, familiarity, and knowledge are still insufficient among Kuantan population. Further studies should be done to tackle this problem before it getting worse.
    KEYWORDS: Electronic-cigarette; Malaysia; experimentation; perception; prevalence
    Comment in: Farsalinos KE, Le Houezec J. Electronic cigarette experimentation in the Malaysian city of Kuantan: Was there an association with the smoking status? J Pharm Bioallied Sci. 2016 Oct-Dec;8(4):347-348
  18. Abdullah SN, Mohmad Sabere AS
    J Pharm Bioallied Sci, 2020 12 21;13(1):143-147.
    PMID: 34084061 DOI: 10.4103/jpbs.JPBS_463_20
    One of the major concerns in any pharmacological treatment is the patients' adherence to medication. However, different types of ocular dosage forms might result in different response and compliance from the patients. This study investigated and compared public willingness on different types of dosage forms available for ocular treatment. The study also evaluated their willingness on new approach for the treatment based on their knowledge, attitude, and perception. This study was conducted between October and December 2017 through a set of questionnaires applied to 90 respondents between the age of 18 and 60 years who lived in Muar and Kuantan, Malaysia. The results were analyzed using SPSS software version 22.0 including inferential and descriptive statistics. There was no significant difference in the knowledge level between all age groups towards different types of dosage forms available; eye drops (P = 0.09), eye ointment (P = 0.252), medicated contact lens (P = 0.05), ocular mini-tablets (P = 0.06), and ocular inserts (P = 0.075). There is a variation of results among the public towards different types of dosage forms with their willingness to try conventional and novel approach. Eye drops show the highest willingness followed by eye ointment (less willingness). However, most of them showed no willingness towards medicated contact lens, ocular mini-tablets, and ocular insert. This research hopes to provide an overview on the development process of new formulation and dosage forms based on the patients' willingness level in an attempt to increase patient compliance.
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