Displaying publications 1081 - 1100 of 55674 in total

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  1. Hu S, Anschuetz L, Hall DA, Caversaccio M, Wimmer W
    Trends Hear, 2021 3 6;25:2331216520986303.
    PMID: 33663298 DOI: 10.1177/2331216520986303
    Residual inhibition, that is, the temporary suppression of tinnitus loudness after acoustic stimulation, is a frequently observed phenomenon that may have prognostic value for clinical applications. However, it is unclear in which subjects residual inhibition is more likely and how stable the effect of inhibition is over multiple repetitions. The primary aim of this work was to evaluate the effect of hearing loss and tinnitus chronicity on residual inhibition susceptibility. The secondary aim was to investigate the short-term repeatability of residual inhibition. Residual inhibition was assessed in 74 tinnitus subjects with 60-second narrow-band noise stimuli in 10 consecutive trials. The subjects were assigned to groups according to their depth of suppression (substantial residual inhibition vs. comparator group). In addition, a categorization in normal hearing and hearing loss groups, related to the degree of hearing loss at the frequency corresponding to the tinnitus pitch, was made. Logistic regression was used to identify factors associated with susceptibility to residual inhibition. Repeatability of residual inhibition was assessed using mixed-effects ordinal regression including poststimulus time and repetitions as factors. Tinnitus chronicity was not associated with residual inhibition for subjects with hearing loss, while a statistically significant negative association between tinnitus chronicity and residual inhibition susceptibility was observed in normal hearing subjects (odds ratio: 0.63; p = .0076). Moreover, repeated states of suppression can be stably induced, reinforcing the use of residual inhibition for within-subject comparison studies.
    Matched MeSH terms: Humans
  2. Azizan E, Brown M
    Malays J Pathol, 2020 Dec;42(3):363-367.
    PMID: 33361716
    In 2003, it was discovered that the entry receptor for the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) is a protein called the angiotensin-converting enzyme 2 (ACE2). This protein is present in a number of cell types, including those from the respiratory tract. Soon after the emergence of SARS-CoV-2 that is responsible for the disease Covid-19, scientists found that ACE2 was also used by the new coronavirus to infect cells. This opened some interesting possibilities to explain the striking variation in risks of catching and dying from Covid-19. The best recognised of these are the much higher risk of serious illness in older than younger people, in men than women, and in those with pre-existing comorbidities such as hypertension and cardiovascular diseases. There are several ways in which the ACE2 protein might contribute to this variation. The most obvious would be if there is more ACE2, there would be more entry points for the virus to infect the cell, e.g. in older people or in men. However, the evidence for this is rather small, partly because it is not that easy to obtain representative healthy tissues. Alternatively, it could be related to ACE2 membership of a family of proteins that has one end of the protein anchored inside the cell while most of the protein protrudes from the outside of the cell which therefore can be shed when cleaved by proteases at the cell membrane. Herein we review current evidence and theories of ACE2 role on SARS-CoV-2 infectivity and Covid-19 severity.
    Matched MeSH terms: Humans
  3. Ahmad Nabir Amir
    MyJurnal
    Kertas ini mengkaji sumbangan Ibn Abī Dunyā (208-281/894) dalam mengembangkan pemikiran tasawuf Islam dan peranannya dalam merumuskan falsafah kesufian yang diungkapkan oleh ahli-ahli sufi yang besar yang berkembang dengan meluas di abad ke 3 Hijrah. Penulisan dan karya-karya tasawuf yang dihasilkan oleh Ibn Abī Dunyā banyak memberikan pengaruh kepada perkembangan ilmu tasawuf di abad pertengahan dan pemikirannya dikutip oleh ulama sufi yang muktabar yang mengasaskan manhaj kesufian Islam yang utama seperti Imām al-Ghazālī, al-Qushayrī, al-Shādhilī, Ibn ‘Arabī, al-Sulamī, al-Kutubī, al-Birgivī dan sebagainya. Cetusan dan fikrah tasawuf yang digagaskannya dizahirkan dalam karya-karyanya yang monumental seperti Dhamm al-Dunyā, Dhamm al-Malāḥī, al-‘Uqūbāt, al-Jū‘, Makārim al-Akhlāq, al-Riqqah wa’l-Bukā’, al-Ṣabr, Iṣṭinā‘ al-Ma‘rūf, al-Muḥtaḍirīn, al-Mutamannīn, Ṣifat al-Nār dan sebagainya. Kertas ini akan menganalisis pemikiran dan sumbangannya yang signifikan ini dalam disiplin tasawuf dan melihat relevensinya dengan idealisme tasawuf moden.
    Matched MeSH terms: Humans
  4. Ashraf K, Ng CJ, Teo CH, Goh KL
    J Glob Health, 2019 Jun;9(1):010405.
    PMID: 30701069 DOI: 10.7189/jogh.09.010405
    Background: Population health indices such as disability adjusted life years (DALY) and quality adjusted life years (QALY) are often used in an effort to measure health of populations and identify areas of concern that require interventions. There has been an increase of number of population health indices since the last review published more than a decade ago. Therefore, this study aims to provide an overview of existing population health indices and examine the methods used to develop them.

    Methods: The search was conducted across three databases: PubMed, CINAHL and Emerald using four key concepts: 'health', 'index', 'context', 'develop', which was supplemented with Google searching and reference scanning. A researcher screened the titles, abstracts and subsequently full texts and confirmed the findings with the research team at each stage. Data charting was performed according to the included publications and identified indices. The collation was performed by describing the indices and made observation on its development method using a priori framework consist of four processes: underpinning theory, model or framework; data selection and processing; formation of index; testing of index.

    Results: Twenty-six publications describing population health indices were included, and 27 indices were identified. These indices covered the following health topics: overall health outcomes (n = 15), outcomes for specific health topics (n = 4), diseases outcome (n = 6), assist health resource allocation for priority minority subgroup or geographic area (n = 4), quality of health or health care (n = 2). Twenty-one indices measure health for general populations while six measure defined subpopulations. Fourteen of the indices reported at least one of the development processes according to the a priori framework: underpinning theory, model or framework (n = 7); data selection and processing (n = 8); formation of index (n = 12); testing of index (n = 9).

    Conclusions: Few population health indices measure specific health topics or health of specific sub-population. There is also a lack of usage of theories, models or framework in developing these indices. Efforts to develop a guideline is proposed on how population health indices can be developed systematically and rigorously to ensure validity and comprehensive assessment of the indices.

    Matched MeSH terms: Humans
  5. Malaya Medical Journal, 1911;9:55-57.
    Matched MeSH terms: Humans
  6. Viswalingam A
    Matched MeSH terms: Humans
  7. Stanton AT, Fletcher W
    Matched MeSH terms: Humans
  8. Sivasambandan R
    Matched MeSH terms: Humans
  9. Tratman EK
    Matched MeSH terms: Humans
  10. Veerasingham KV, Rasanayagam S
    Matched MeSH terms: Humans
  11. Veerasingham KV, Somasundaram A
    Matched MeSH terms: Humans
  12. Simpson IA, Lim EC
    Malayan Medical Journal, 1935;10:138-9.
    Matched MeSH terms: Humans
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