MyMedR

Fulltext Oral speckled leukoplakia--report of two cases

Yaacob HB, Mahfuz Ali MA, Hamid JA

Med J Malaysia, 1983 Jun;38(2):118-20.

Two cases of oral speckled leukoplakia with differing behaviour are presented. This precancerous lesion of unknown aetiology requires early diagnosis for proper management. Candida albicans are frequently found in these lesions. The significance of epithelial dysplasia in relation to treatment is discussed. Surgical removal is the treatment of choice.

Matched MeSH terms: Middle Aged

Fulltext Carotid body tumour--a case report

Mohamad AS, Rejab E, Said H

Med J Malaysia, 1989 Jun;44(2):174-7.

PMID: 2626128

A case of carotid body tumour is presented. Pathology, diagnostic investigations, modalities of treatment and prognosis are discussed. With greater awareness of this condition and improvement in diagnostic investigations and surgical techniques, the outlook in managing this condition should be better.

Matched MeSH terms: Middle Aged

Fulltext Faecaloma of the rectum: a case report

Krishnan MMS

Med J Malaysia, 1984 Dec;39(4):320-2.

PMID: 6544943

Matched MeSH terms: Middle Aged

Report of a rare case of tracheal foreign-body in an adult

Majeed AR

Med J Malaysia, 1978 Dec;33(2):146-8.

PMID: 755166

Matched MeSH terms: Middle Aged

Basaloid Nasopharyngeal Carcinoma: An Entity That Remains Oblivious

Ganeson SK, Saniasiaya J, Mohamad I, Abdul Gani N

Gulf J Oncolog, 2020 Sep;1(34):83-86.

PMID: 33431368

INTRODUCTION: Basaloid squamous cell carcinoma of the nasopharynx is a rare entity with only scarce cases reported in the English Literature. It is a histological variant of squamous cell carcinoma with aggressive nature and comprises of both basal cell carcinoma and squamous cell carcinoma.

CASE PRESENTATION: Herein, we report on a middleaged male who presented with left-sided spontaneous epistaxis and aural fullness with no neck node which turned out to be basaloid cell carcinoma of nasopharynx.

DISCUSSION AND CONCLUSION: We highlight high clinical suspicion of rare variant of nasopharyngeal carcinoma although no palpable node was evident upon presentation.

Matched MeSH terms: Middle Aged

Carotid body tumour -- a case report

Rajapaksa AC, Kwee NK

Med J Malaysia, 1976 Sep;31(1):73-4.

PMID: 1023018

Matched MeSH terms: Middle Aged

Fulltext Duodenal leiomyosarcoma: a report of a rare and aggressive tumour

Ho YN, Leong YP, Sakijan AS, Swaminathan M, Sarvananthan K

Singapore Med J, 1992 Jun;33(3):297-8.

PMID: 1631594

A 45-year-old Malay lady who presented with intermittent abdominal pain and a left hypochondrial mass was found to have a 10 x 8 x 5 cm duodenal tumour without local invasion at laparotomy. En bloc resection of the tumour with adequate margin of clearance was done and histopathological diagnosis of low grade leiomyosarcoma was made. Fourteen months later, she returned with multiple metastases in the liver and needed palliative chemotherapy for pain relief. Duodenal leiomyosarcomata are very rare tumour. Their prognostic indicators include biological grading, tumour size and presence of metastases. Recognition of its high malignant potential calls for close surveillance calls even after apparent curative surgery.

Matched MeSH terms: Middle Aged

Fulltext Idiopathic CD4 lymphopenia in a case of disseminated cryptococcosis with brain, vertebral spine and reproductive organ involvement

Sim BNH, Hui LY, Krishnan D, Joseph JP

Clin Med (Lond), 2019 Mar;19(2):133-134.

PMID: 30872296 DOI: 10.7861/clinmedicine.19-2-133

Cryptococcosis is an opportunistic fungal infection commonly seen in HIV cases. We present a case of disseminated cryptococcosis with multiple non-continuous infective foci in a non-HIV, non-transplant case.

Matched MeSH terms: Middle Aged

A rare case of pigmented seborrhoeic keratosis of scalp

Arosish D

Med J Malaysia, 2025 Jan;80(Suppl 1):80-83.

PMID: 39773948

Seborrheic keratosis (SK) is a prevalent hyperkeratotic dermatological condition characterized by benign proliferation of epidermal keratinocytes, typically occurring in the middle to advanced stages of life. While the trunk is the primary site for lesions, they can also manifest on the extremities, face, and scalp. Although SK is typically benign, there can be morphological overlap with malignant skin lesions, necessitating meticulous differentiation for an accurate diagnosis. This case report describes a 63-year-old male presenting with scalp swelling that was, initially suspected to be malignant. However, histopathological examination revealed pigmented seborrheic keratosis, prompting the need for a comprehensive management approach. Surgical excision with a rotational flap cover was performed successfully, highlighting the importance of precise diagnosis and management in addressing cutaneous lesions. The exact etiology of SK remains elusive, with potential genetic associations implicated in its pathogenesis. Although treatment may not always be necessary, various modalities are available for lesion removal or symptom management, with surgical intervention reserved for cases exhibiting signs of malignancy. Clinicians should be aware of the atypical presentations of SK and, emphasize the need for a multidisciplinary approach involving dermatologists, pathologists, and surgeons for optimal outcomes.

Matched MeSH terms: Middle Aged

Report on two cases of hyperosmolar, hyperglycaemic nonketotic diabetic coma

Gip LS, Chong KF, Omar AR

Med J Malaysia, 1978 Dec;33(2):150-3.

PMID: 755167

Matched MeSH terms: Middle Aged

T3 toxicosis--a case report

Mahadev V, Seng NT, Woo LG

Med J Malaysia, 1976 Jun;30(4):328-30.

PMID: 979740

Matched MeSH terms: Middle Aged

Fulltext Popeye's sign: biceps tendon rupture

Lim CH, Lee KA, Liew JW

BMJ Case Rep, 2020 Feb 04;13(2).

PMID: 32024720 DOI: 10.1136/bcr-2019-234205

Matched MeSH terms: Middle Aged

Fulltext Inflammatory bowel disease and associated cardiovascular disease outcomes: A systematic review

Jaiswal V, Batra N, Dagar M, Butey S, Huang H, Chia JE, et al.

Medicine (Baltimore), 2023 Feb 10;102(6):e32775.

PMID: 36820570 DOI: 10.1097/MD.0000000000032775

BACKGROUND: There is limited and conflicting data available regarding the cardiovascular disease outcomes associated with inflammatory bowel disease (IBD).

OBJECTIVE: We aim to perform a systematic review to evaluate the cardiovascular outcomes and mortality associated with IBD patients.

METHODS: A systematic literature search has been performed on PubMed, Embase, Cochrane, and Scopus from inception till May 2022 without any language restrictions.

RESULTS: A total of 2,029,941 patients were included in the analysis from 16 studies. The mean age of the patients was 45.6 years. More females were found compared with males (57% vs 43%). The most common risk factors for cardiovascular disease (CVD) included smoking (24.19%) and alcohol (4.60%). The most common comorbidities includes hypertension (30%), diabetes mellitus (14.41%), dyslipidemia (18.42%), previous CVD (22%), and renal disease (10%). Among outcomes, all-cause mortality among IBD patients was 1.66%; ulcerative colitis (UC): 15.92%; and Crohn disease (CD): 0.30%. Myocardial Infarction (MI) among IBD patients were 1.47%, UC: 30.96%; and CD: 34.14%. CVD events among IBD patients were 1.95%. Heart failure events among IBD patients were 5.49%, stroke events among IBD patients were 0.95%, UC: 2.63%, and CD: 2.41%, respectively.

CONCLUSION: IBD patients are at higher risk for adverse cardiovascular outcomes, especially in women. Although there remains a lack of concrete treatment algorithms and assessment parameters that better characterize IBD risk factors, nutritional modifications and physical activity should be at the forefront of CVD prevention in IBD.

Matched MeSH terms: Middle Aged

Fulltext Gestational trophoblastic disease in a 54-year old woman--a case report

Tharmaseelan NK

Singapore Med J, 1990 Dec;31(6):627-8.

PMID: 2177919

A rare case of gestational trophoblastic disease (GTD) in a 54-year old Malay woman is described. A total abdominal hysterectomy with bilateral salphingo-oopherectomy was done. She was given methotrexate therapy as she had persistent high levels of serum B hCG.

Matched MeSH terms: Middle Aged

Female urethral diverticulum complicated with urethral calculi

Noor Affendi NF, Mohd Yusoff F, Ghazali H, Abd Kadir NJ

BMJ Case Rep, 2025 Feb 11;18(2).

PMID: 39933841 DOI: 10.1136/bcr-2024-264043

Female urethral diverticulum is a rare phenomenon, which is often discovered due to its associated complications. Delayed diagnosis is not uncommon due to the varied non-specific symptoms and clinical features. We are highlighting a case of female urethral diverticulum complicated with urethral calculi. She had recurrent lower urinary tract symptoms for the past 3 years and presented with recent dyspareunia. Transvaginal diverticulectomy and local extraction of the calculi successfully treated the condition. A high index of suspicion is required to successfully diagnose this condition early, not only for symptom relief but also to prevent complications.

Matched MeSH terms: Middle Aged

Fulltext Meningioma En Plaque Associated with Cerebrospinal Fluid Rhinorrhea: A Systematic Review of the Literature with Case Presentation

Abouammo MD, Alsavaf MB, Biswas C, Narayanan MS, Mansur G, Gehrke RD, et al.

World Neurosurg, 2025 Feb;194:123371.

PMID: 39486580 DOI: 10.1016/j.wneu.2024.10.100

BACKGROUND: Meningiomas are the most frequently diagnosed benign intracranial tumors. However, meningioma en plaque (MEP) is a rare subset accounting for 2.5% of all meningiomas and is characterized by flat, carpetlike proliferation along the dura, typically arising in the spheno-orbital region, and, therefore, causes proptosis, decreased visual acuity, and orbital pain. We present a unique case of a patient with MEP presenting with cerebrospinal fluid (CSF) rhinorrhea and conduct a systematic review of the literature.

METHODS: Following PRISMA guidelines, a systematic search was conducted in PubMed and Embase databases. Keywords and standardized index terms related to MEP were used. The search was performed without restriction on the publication date. Screening, data extraction, and quality assessment were carried out. Data on demographics, clinical presentations, management modalities, and treatment outcomes were analyzed.

RESULTS: The search yielded 487 titles, with 36 studies eligible for inclusion. A total of 530 patients with MEP were reported, with a mean age of 50.1 ± 11.62 years. Proptosis was the most common symptom (95%), followed by visual impairment (57.3%), orbital pain (38.3%), ophthalmoplegia (28.6%), and headache (23%). Our patient represented the only case of a patient with a spontaneous CSF leak. Surgical resection was performed in 85%, adjuvant radiotherapy in 15.7%, and 1 patient received primary radiotherapy, and 8 patients were closely followed up with no intervention.

CONCLUSIONS: MEP associated with spontaneous CSF rhinorrhea is extremely rare and poses diagnostic and therapeutic challenges. Conservative management for select cases of MEP can be a good choice, sparing the patient from surgical complications, especially for skull base areas that are difficult to access.

Matched MeSH terms: Middle Aged

Mismanagement of cat bite wound: lessons to learn

Muthupalaniappen L, Siti Aishah MA, Wong YP, Jamil A

Clin Ter, 2013 May-Jun;164(3):225-7.

PMID: 23868624 DOI: 10.7417/CT.2013.1553

Animal inflicted wounds, left untreated may result in chronic bacterial or fungal infection. Clinical features of these infections may overlap leading to a delay in diagnosis and treatment. We report a case of chronic non-healing cat bite wound treated with several antibiotics without improvement. Later patient developed the classical "sporotrichoid spread" and a presumptive diagnosis of sporotrichosis was made. Laboratory investigation for fungal culture and skin biopsy failed to identify the underlying pathogen. A trial of oral antifungal agent resulted in complete recovery of the lesions implicating fungus as the causative pathogen. Physicians should have a high index of suspicion for fungal infections when managing animal inflicted wounds.

Matched MeSH terms: Middle Aged

An interesting case of autonomic dysreflexia

Ohnmar H, Das S, Naicker AS

Clin Ter, 2009;160(5):371-3.

PMID: 19997683

Autonomic dysreflexia (AD) is not an uncommon clinical condition and it is usually detected in patients with complete spinal injuries at or above thoracic 6th vertebral level (T 6). This condition is reported to occur in 48- 60% of cases of spinal cord injury at or above the level of T6. But AD due to injury below T6 is rare. The basic mechanism is thought to be due to excessive, uncontrolled activation of sympathetic system. In the present case, we discuss a persistent AD in 55-yr-old tetraplegic patient with C5 American Spinal Injury Association (ASIA) grade A lesion due to a fall from 10 metre height. MRI examination showed C5 and C6 bi-facets fracture and dislocation with canal compromise. Wiring and fusion was performed but recurrent mucous plugging and aspiration pneumonia and urinary tract infection happened during the hospital stay. Three months later, he was re-admitted with multiple pressure sores, pneumonia, sepsis and high blood pressure. He was administered with nifedepine but the blood pressure kept fluctuating. The present study highlights how the precipitating factors like concomitant urinary tract infection, decubitus ulcers, spasticity triggered the AD attack. The knowledge of the AD and its proper diagnosis and management may be beneficial to all clinicians and the present article attempts to highlight such.

Matched MeSH terms: Middle Aged

Anatomical study of anomalous posterior horn of lateral ventricle of brain and its clinical significance

Srijit D, Shipra P

Bratisl Lek Listy, 2007;108(9):422-4.

PMID: 18225483

The present cadaveric study, describes asymmetrical right cerebral hemisphere and anomalous posterior horn of the right lateral ventricle and discusses its clinical implications. The occipital lobe of right cerebral hemisphere extended more posteriorly as compared to the left and so did the posterior horn of the lateral ventricle, resulting in the thinning of the occipital cortex. Till now, the dimension and volumetric study of the lateral ventricles have been usually performed by MRI and CT scans. A gross anatomical study of such a case, is the rarest of its kind. The abnormal anatomy of the lateral ventricles may be of great academic interest regarding CSF circulation and also important for clinical, radiological and surgical interventions (Fig. 2, Ref 8). Full Text (Free, PDF) www.bmj.sk.

Matched MeSH terms: Middle Aged

Fulltext A rare case of chondrosarcoma of the clavicle

Amalourde A, Vinayaga P, Naveed N, Jamal A, Looi LM, Sengupta S

Med J Malaysia, 2004 Dec;59 Suppl F:60-2.

PMID: 15941166 MyJurnal

Although all types of tumour and tumour-like conditions have been described to occur in the clavicle, they only contribute to less then 0.5% of all skeletal tumours. The incidence of primary chondrosarcoma of the clavicle is extremely rare. To our knowledge it has not been reported in Malaysia. We would like to highlight the possibility of chondrosarcoma as a differential diagnosis for a clavicular lesion.

Matched MeSH terms: Middle Aged

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