MyMedR

Displaying all 5 publications

Abstract:

Sort:

Fulltext RETRACTED ARTICLE: Social media analytics and their applications to evaluate an activity in online health interventions using CRITIC and TOPSIS techniques

Lin Y, Alshehri Y, Alnazzawi N, Abid M, Khan SA, Jabeen F, et al.

Soft comput, 2024 Dec;28(Suppl 2):481.
PMID: 37362268 DOI: 10.1007/s00500-023-08004-3
Fulltext Axial Compressive Strength Models of Eccentrically-Loaded Rectangular Reinforced Concrete Columns Confined with FRP

Isleem HF, Abid M, Alaloul WS, Shah MK, Zeb S, Musarat MA, et al.

Materials (Basel), 2021 Jun 23;14(13).
PMID: 34201659 DOI: 10.3390/ma14133498

The majority of experimental and analytical studies on fiber-reinforced polymer (FRP) confined concrete has largely concentrated on plain (unreinforced) small-scale concrete columns, on which the efficiency of strengthening is much higher compared with large-scale columns. Although reinforced concrete (RC) columns subjected to combined axial compression and flexural loads (i.e., eccentric compression) are the most common structural elements used in practice, research on eccentrically-loaded FRP-confined rectangular RC columns has been much more limited. More specifically, the limited research has generally been concerned with small-scale RC columns, and hence, the proposed eccentric-loading stress-strain models were mainly based on the existing concentric-loading models of FRP-confined concrete columns of small scale. In the light of such demand to date, this paper is aimed at developing a mathematical model to better predict the strength of FRP-confined rectangular RC columns. The strain distribution of FRP around the circumference of the rectangular sections was investigated to propose equations for the actual rupture strain of FRP wrapped in the horizontal and vertical directions. The model was accomplished using 230 results of 155 tested specimens compiled from 19 studies available in the technical literature. The test database covers an unconfined concrete strength ranging between 9.9 and 73.1 MPa, and section's dimension ranging from 100-300 mm and 125-435 mm for the short and long sides, respectively. Other test parameters, such as aspect ratio, corner radius, internal hoop steel reinforcement, FRP wrapping layout, and number of FRP wraps were all considered in the model. The performance of the model shows a very good correlation with the test results.
Fulltext Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches

Ahsan N, Rao RSP, Wilson RS, Punyamurtula U, Salvato F, Petersen M, et al.

Proteomics, 2021 05;21(10):e2000279.
PMID: 33860983 DOI: 10.1002/pmic.202000279

While protein-protein interaction is the first step of the SARS-CoV-2 infection, recent comparative proteomic profiling enabled the identification of over 11,000 protein dynamics, thus providing a comprehensive reflection of the molecular mechanisms underlying the cellular system in response to viral infection. Here we summarize and rationalize the results obtained by various mass spectrometry (MS)-based proteomic approaches applied to the functional characterization of proteins and pathways associated with SARS-CoV-2-mediated infections in humans. Comparative analysis of cell-lines versus tissue samples indicates that our knowledge in proteome profile alternation in response to SARS-CoV-2 infection is still incomplete and the tissue-specific response to SARS-CoV-2 infection can probably not be recapitulated efficiently by in vitro experiments. However, regardless of the viral infection period, sample types, and experimental strategies, a thorough cross-comparison of the recently published proteome, phosphoproteome, and interactome datasets led to the identification of a common set of proteins and kinases associated with PI3K-Akt, EGFR, MAPK, Rap1, and AMPK signaling pathways. Ephrin receptor A2 (EPHA2) was identified by 11 studies including all proteomic platforms, suggesting it as a potential future target for SARS-CoV-2 infection mechanisms and the development of new therapeutic strategies. We further discuss the potentials of future proteomics strategies for identifying prognostic SARS-CoV-2 responsive age-, gender-dependent, tissue-specific protein targets.
Fulltext Diagnostic utility of electrocardiogram for screening of cardiac injury on cardiac magnetic resonance in post-hospitalised COVID-19 patients: a prospective multicenter study

Samat AHA, Cassar MP, Akhtar AM, McCracken C, Ashkir ZM, Mills R, et al.

Int J Cardiol, 2024 Nov 15;415:132415.
PMID: 39127146 DOI: 10.1016/j.ijcard.2024.132415

BACKGROUND: The role of ECG in ruling out myocardial complications on cardiac magnetic resonance (CMR) is unclear. We examined the clinical utility of ECG in screening for cardiac abnormalities on CMR among post-hospitalised COVID-19 patients.
METHODS: Post-hospitalised patients (n = 212) and age, sex and comorbidity-matched controls (n = 38) underwent CMR and 12‑lead ECG in a prospective multicenter follow-up study. Participants were screened for routinely reported ECG abnormalities, including arrhythmia, conduction and R wave abnormalities and ST-T changes (excluding repolarisation intervals). Quantitative repolarisation analyses included corrected QT (QTc), corrected QT dispersion (QTc disp), corrected JT (JTc) and corrected T peak-end (cTPe) intervals.
RESULTS: At a median of 5.6 months, patients had a higher burden of ECG abnormalities (72.2% vs controls 42.1%, p = 0.001) and lower LVEF but a comparable cumulative burden of CMR abnormalities than controls. Patients with CMR abnormalities had more ECG abnormalities and longer repolarisation intervals than those with normal CMR and controls (82% vs 69% vs 42%, p
Fulltext Expert Opinion: Patient Selection for Premixed Insulin Formulations in Diabetes Care

Kalra S, Czupryniak L, Kilov G, Lamptey R, Kumar A, Unnikrishnan AG, et al.

Diabetes Ther, 2018 Dec;9(6):2185-2199.
PMID: 30390228 DOI: 10.1007/s13300-018-0521-2

Premixed insulins are an important tool for glycemic control in persons with diabetes. Equally important in diabetes care is the selection of the most appropriate insulin regimen for a particular individual at a specific time. Currently, the choice of insulin regimens for initiation or intensification of therapy is a subjective decision. In this article, we share insights, which will help in rational and objective selection of premixed formulations for initiation and intensification of insulin therapy. The glycemic status and its variations in a person help to identify the most appropriate insulin regimen and formulation for him or her. The evolution of objective glucometric indices has enabled better glycemic monitoring of individuals with diabetes. Management of diabetes has evolved from a 'glucocentric' approach to a 'patient-centered' approach; patient characteristics, needs, and preferences should be evaluated when considering premixed insulin for treatment of diabetes.Funding: Novo Nordisk, India.