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Fulltext A systematic review on the anti-oxidative and anti-inflammatory properties of Ficus carica

Norfarah, I.R., Adlina, M., Nadia, M.E.

ASM Science Journal, 2018;11(2):124-145.
MyJurnal

Oxidative stress (OXS) has been associated with many diseases such as neurodegenerative diseases, cancer, diabetes and osteoporosis as it can alter cellular components in the body. Oxidative stress can be neutralised by anti-oxidative compounds found in many natural products such as berries, turmeric and figs. The objective of this paper is to evaluate the anti-oxidative and anti-inflammatory properties of figs. Fig, or its scientific name Ficus carica (F. carica), is one of the fruits mentioned in the Quran and is known among the Malays as ‘buah tin’. Electronic databases used were Scopus, Ovid, Proquest and Science Direct. The inclusion criteria were studies that utilised the fresh, dried, juice, extract of F. carica, written in English, published within 2007 to 2017, studies carried out in tissue culture and animal studies. Anti-oxidative effect, lipid peroxidation inhibition and anti-inflammatory were the key outcomes in this review. A total of 19 studies met all the criteria. The results showed that treatment with F. carica increased anti-oxidative enzymes such as catalase, superoxide dismutase, glutathione peroxidase and decreased lipid peroxidation activity. F. carica also reported to reduce pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in acute and chronic inflammation. In conclusion, F. carica exhibited anti-oxidative and anti-inflammatory properties.
Fulltext The effects of ficus caricafruit on bone markers and oestrogen level of post-menopausal osteoporotic rats.

Norfarah Izzaty R, Nur Adlina M,, Mohd Dzulkhairi MR, Muhammad Shamsir MA,, Nadia ME

IIUM Medical Journal Malaysia, 2019;18(1):97-104.
MyJurnal

Post-menopausal osteoporosis is the most common type of osteoporosis, which occurs due to a deficiency of oestrogen following menopause. Considering the adverse effects of oestrogen replacement therapy, natural products may serve to replace the current conventional treatment. Ficus carica (FC) which is commonly known as fig may have a potential in treating post-menopausal osteoporosis due to their abundance of important minerals and bioactive compounds such as phenolic, flavonoid and anthocyanins. This study aimed to evaluate the effects of FC on bone metabolism of ovariectomized rats. Materials and Methods:Fifty-six female Spraque-Dawley rats were randomly divided into seven groups; SHAM operated (SHAM), ovariectomized control (OVX), ovariectomized + 64.5 μg/kg oestrogen (ERT), ovariectomized + 50 mg/kg aqueous extract of FC(AQ50), ovariectomized + 100 mg/kg aqueous extract of FC (AQ100), ovariectomized + 50 mg/kg raw FC (RW50), and ovariectomized + 100 mg/kg raw FC (RW100). After eight weeks of treatments, rats were euthanized and femurs were dissected out to measure bone osteocalcin, C-telopeptide of type 1 collagen and bone estrogen level. Results:RW50 and RW100 showed an increasing trend in osteocalcin levels and also oestrogen level, but no significant difference between all groups. RW50 and RW100 also showed significantly reduced C-telopeptide of type 1 collagen levels compared to OVX group. Conclusion:These findings suggested that raw FC at the doses of 50 mg/kg and 100 mg/kg have potential to improve bone in treating post-menopausal osteoporosis. However, this need to be confirmed with higher doses.
Prevalence of COVID-19 among healthcare workers in the paediatric department: Estimates from a multicenter cross-sectional survey in Negeri Sembilan

David NCE, Juliana H, Chok M, Gan YZ, Tan YC, Nur Adlina MN, et al.

Med J Malaysia, 2023 Jan;78(1):80-86.
PMID: 36715196

INTRODUCTION: The COVID-19 pandemic has reached a phase where many have been infected at least once. Healthcare workers were not spared from being infected. This study aimed to determine the period prevalence of COVID-19 among the paediatric healthcare workers in Negeri Sembilan as the country transitioned into an endemic phase of the pandemic. Additionally, we investigate potential sociodemographic and occupational characteristics associated with SARS-CoV-2 infection among healthcare workers.
MATERIALS AND METHODS: A cross-sectional study was conducted among the healthcare workers in the paediatric department at three public specialist hospitals in Negeri Sembilan between 15 and 21 April 2022. Data were collected through a self-administered questionnaire.
RESULTS: Out of the 504 eligible healthcare workers, 493 participated in this study (response rate 97.8%). The overall prevalence of COVID-19 (11 March 2020-15 April 2022) among healthcare workers was 50.9%. The majority (80.1%) were infected during the Omicron wave two months before the survey. Household contacts accounted for 35.9% of infection sources. The proportion of non-doctors in the COVID-19-infected group was significantly higher compared to the non-infected group (74.1% vs 64.0%, p=0.016). The COVID-19-infected group had a higher proportion of schoolgoing children (44.6% vs 30.6%, p=0.001) and children who attended pre-school/sent to the babysitter (49.0% vs 24.4%, p<0.001). There were no significant differences between infection rates among the healthcare workers working in the tertiary hospital and the district hospitals. There were also no significant differences in the proportion of COVID-19- infected doctors and nurses when analysed by seniority.
CONCLUSION: Our study provided an estimate on the prevalence of COVID-19 among paediatric healthcare workers in Negeri Sembilan and the factors associated with infection, which captures the extent and magnitude of this pandemic on the state's paediatric department. Most infections resulted from household contact, with a higher proportion of infected healthcare workers having young children.

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