Present research investigated the impact of executive dysfunction on academic performance among
students in their middle childhood. It was hypothesized that school teacher’s rating of executive
dysfunction in students can significantly predict their performance in Mathematics and Science
subjects. The study used primary data which was collected from public schools of Lahore. An
indigenized executive dysfunction inventory was constructed for this purpose and psychometric
properties were established. It was postulated that student’s performance in Science and Math will vary
based on their executive dysfunction and the results attested to this hypothesis. Demographic properties
were also evaluated through age, number of siblings, gender, family system, and mother profession.
Statistical findings revealed that higher level of executive dysfunction is associated with lower level of
science and math performance.
A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba. Currently, no therapeutic agent can completely eradicate or prevent GAE. Synthetic compounds are a likely source of bioactive compounds for developing new drugs. This study synthesized seventeen 1,4-benzothiazine derivatives (I -XVII) by a base-catalyzed one-pot reaction of 2-amino thiophenol with substituted bromo acetophenones. Different spectroscopic techniques, such as EI-MS, 1H-, and 13C NMR (only for the new compounds), were used for the structural characterization and conformation of compounds. These compounds were assessed for the first time against Acanthamoeba castellanii. All compounds showed anti-amoebic potential in vitro against A. castellanii, reducing its ability to encyst and excyst at 100 μM. Compounds IX, X, and XVI showed the most potent activities among all derivatives and significantly reduced the viability to 5.3 × 104 (p