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Fulltext Stress, psychological well-being and coping strategies among nurses in Sabah

Chin Lee Mei @ Mary Tan, Mohd Dahlan A. Malek, Ismail Maakip

Malaysian Journal of Medicine and Health Sciences, 2020;16(105):30-0.
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Introduction: Nursing is a highly stressful profession that affects the nurses’ physical and mental health. To maintain the quality of health services, nurses must have physically and mentally healthy. Given this, the present study aimed to examine the level of Stress and Psychological Well-Being among nurses and the methods used by nurses to cope with them. Methods: A self-administered questionnaire was used to assess psychological well-being and coping strat- egies with stress which include Ryff’s Psychological Well-Being (RPWB), Ways of Coping Questionnaire (WOCQ) and Nursing Stress Scales (NSS) for the data collection on 637 nurses in nine hospitals in Sabah. Results: The results revealed that the main Sources of Stress among nurses was Conflict with Other Nurses. Also, Purpose in Life was found to have the highest mean score in terms of psychological well-being among nurses. Furthermore, Positive Re- appraisal was found to be employed by nurses in dealing with stress. The study also revealed there was relationship between the sources of stress and the psychological well-being among nurses. Conclusion: Thus, to reduce work stress among nurses, hospital administration should keep themselves aware of the work dynamics and address the negative conflict occurred in nurses as soon as it is recognized. Recognizing the impact of work stress and using the technique of coping plays a vital role in minimizing the stress of nurses.
Fulltext The effect of integrative therapy treatment on depression and aggresion among inmates

Azahar Che Latiff, Mohd Dahlan A. Malek, Wan Anor Wan Sulaiman, Puteri Hayati Megat Ahmed

Malaysian Journal of Social Sciences and Humanities, 2018;3(4):73-82.
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The purpose of this study is to identify the effectiveness of integrative therapy treatment towards
depression and aggression among prison inmates. Integrative therapy in this study refers to treatment
module which are consisted of four integrated theories in a counselling process. It involved the
combined therapy of Person Client Centred (PCC), Rational Emotions Behaviour Therapy (REBT)
and Choice Theory Reality Therapy (CTRT) as technical treatment. Meanwhile, Stimulus Organism
Response (SOR) act as educational principle or training. Integrative therapy is conducted on the
respondents for six session of group counselling. This study is a quasi-experiment involving 160 depressed prison inmates (80 treatment; 80 control) and 140 aggressive inmates (70 treatment; 70
control) from five prison institutions as the respondent for this study using purposive sampling.
Inmates are identified as respondents using high cutting point of depression using Beck Depression
Inventory (BDI) and high aggression using Aggressive Questionnaires (AQ). For the data analysis, nonparametric
test such as Mann-Whitney Test and Wilcoxon Signed Rank Test were used based on the
normality test using Kolmogorov-Smirnov and Shapiro-Wilk test. Result from the Mann-Whitney Test
shows that the treatment group had higher declining rate as compared to the controlled group for
depression and aggression. Wilcoxon Signed Rank Test also shows the same result as the treatment
group indicates a decline in rate from the pre and post of the treatment compared to the controlled
group. The results of this study are hope to act as the medium for using integrative model which is
rarely use in studies in this country especially in the field of treatment for prison inmates. It is also
expected that it can be applied in different setting which offer treatment service such as hospitals,
social work institution, police institute, schools, higher learning institutions and others.
Fulltext Development and characterization of liposomal doxorubicin hydrochloride with palm oil

Sabeti B, Noordin MI, Mohd S, Hashim R, Dahlan A, Javar HA

Biomed Res Int, 2014;2014:765426.
PMID: 24795894 DOI: 10.1155/2014/765426

The usage of natural products in pharmaceuticals has steadily seen improvements over the last decade, and this study focuses on the utilization of palm oil in formulating liposomal doxorubicin (Dox). The liposomal form of Dox generally minimizes toxicity and enhances target delivery actions. Taking into account the antiproliferative and antioxidant properties of palm oil, the aim of this study is to design and characterize a new liposomal Dox by replacing phosphatidylcholine with 5% and 10% palm oil content. Liposomes were formed using the freeze_thaw method, and Dox was loaded through pH gradient technique and characterized through in vitro and ex vivo terms. Based on TEM images, large lamellar vesicles (LUV) were formed, with sizes of 438 and 453 nm, having polydispersity index of 0.21 ± 0.8 and 0.22 ± 1.3 and zeta potentials of about -31 and -32 mV, respectively. In both formulations, the entrapment efficiency was about 99%, and whole Dox was released through 96 hours in PBS (pH = 7.4) at 37°C. Comparing cytotoxicity and cellular uptake of LUV with Caelyx(R) on MCF7 and MDA-MBA 231 breast cancer cell lines indicated suitable uptake and lower IC50 of the prepared liposomes.
Fulltext Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials

Sitalaksmi RM, Azharpratomo R, Irsan SN, Rahmania PN, Wati SM, Adam SS, et al.

J Oral Biol Craniofac Res, 2025;15(1):63-68.
PMID: 39758354 DOI: 10.1016/j.jobcr.2024.12.002

BACKGROUND: Tooth extraction without socket preservation will lead to reduction in the dimensions and volume of the alveolar bone. Bone defects resulting from tooth extraction not only hinder prosthetic reconstruction but also present aesthetic issues and complicating dental implant treatment. Purple leaves contains flavonoids, steroids, tannins, saponins,and non-toxic alkaloids. These compounds play roles as antimicrobials, immunomodulators, antioxidants, anti-inflammatories, analgesics. Hydroxyapatite has good biocompatibility, and can induce osteoblast differentiation.
AIM: To investigate the effects of the combining nanoemulsion extract of purple leaves and hydroxyapatite on the expression of RUNX2, OSX, OPN, ALP, and calcium deposition.
METHOD: This research used MTT Assay, ICC, and Alizarin Red staining. The study groups were as follows: Group 1: Ad-MSCs; Group 2: Ad-MSCs + αmem; Group 3: Ad-MSCs + osteogenic medium + 1 % nano-extract of Purple leaves & Hydroxyapatite; Group 4: Ad-MSCs + osteogenic medium + 2 % nano-extract of Purple leaves & Hydroxyapatite. Observations were conducted on days 7, 14, and 21.
RESULTS: The combination of nanosuspension extract of Purple leaves and hydroxyapatite significantly increased the expression of RUNX2, OSX, OPN,ALP and calcium deposition compared to other groups. The combination of nanoemulsion extract of Purple leaves and hydroxyapatite were significant (P