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Fulltext Watermelon radioprotection against radiation stress in mice

Md Saad, W.M., Mohd Nor, N.A., Abdul Razak, H.R., Mat Salleh, M.S., Abdul Rasid, A., Hanifah, R.

Pertanika Journal of Science & Technology, 2018;26(2):811-820.
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Ionising radiation (IR) has been extensively used as therapy and diagnostic modality to detect abnormalities inside a human body. Interaction between IR and cells can lead to production of free radicals. This study aims to evaluate radioprotective properties of 50% watermelon juice against low dose ionising radiation (LDIR)-induced stress in mice lung and liver tissues following 14 days of juice supplementation. Eighteen (18) ICR mice were randomly divided into three groups, negative control (Cx), radiation (Rx) and treatment group (Tx). The Cx group was treated with normal diet and filtered water while the Rx group was given a normal diet, filtered water and irradiated with 100 µGy x-ray; Tx group was fed a normal diet, 50% watermelon juice and irradiated with 100 µGy x-ray. After 14 days, level of superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA) in lung and liver tissues were evaluated. The SOD inhibition activity revealed a significant decrease in Rx and Tx compared with Cx (p
Fulltext Musculoskeletal Corticosteroid Injection during COVID-19 Pandemic in Sabah: Is It Safe?

Azwan Aziz M, Abu Hanifah R, Mohd Nahar AM

Adv Orthop, 2021;2021:8863210.
PMID: 33824767 DOI: 10.1155/2021/8863210

Musculoskeletal corticosteroid injection is commonly used as an adjunct to help patients in pain management. In this current COVID-19 pandemic, many clinicians would differ from this treatment as steroid is considered an immunosuppressive drug and could risk the patient of developing severe adverse effects if contracting COVID-19. This is a retrospective study based in Sabah, Malaysia, examining the prevalence of COVID-19 infection following musculoskeletal corticosteroid injection from 1 December 2019 until 30 June 2020 in the sports medicine clinic and the orthopedic clinic. Patients who received musculoskeletal corticosteroid injection were called by telephone and asked about visits to the emergency department or government health clinic for influenza-like illness symptoms or severe acute respiratory infection that would require screening of COVID-19. Thirty-five patients who responded to the call were included, with mean ages of 47.9 years ± 15.1. 52% were male respondents, while 48% were female. 25% of them were diabetics, and 2.9% of them had a history of lymphoproliferative disorders. The mean pain score before injection was 6.74 ± 1.03 and after injection pain was 2.27 ± 1.63. In this study, there were 11.4% (n = 4) with minor complications of steroid injection, that is, skin discoloration. Nonetheless, there were no severe complications due to corticosteroids reported. There were no reported cases of COVID-19 among the respondents following corticosteroid injection. Musculoskeletal pain would affect a person's well-being and activities; thus, its management requires that careful consideration with risk-benefit analysis be made before administering musculoskeletal corticosteroid injection during COVID-19 pandemic.
Fulltext The correlates of body composition with heart rate recovery after step test: an exploratory study of Malaysian adolescents

Abu Hanifah R, Mohamed MN, Jaafar Z, Mohsein NA, Jalaludin MY, Majid HA, et al.

PLoS One, 2013;8(12):e82893.
PMID: 24349388 DOI: 10.1371/journal.pone.0082893

BACKGROUND: In adults, heart rate recovery is a predictor of mortality, while in adolescents it is associated with cardio-metabolic risk factors. The aim of this study was to examine the relationship between body composition measures and heart rate recovery (HRR) after step test in Malaysian secondary school students.
METHODS: In the Malaysian Health and Adolescents Longitudinal Research Team (MyHEART) study, 1071 healthy secondary school students, aged 13 years old, participated in the step test. Parameters for body composition measures were body mass index z-score, body fat percentage, waist circumference, and waist height ratio. The step test was conducted by using a modified Harvard step test. Heart rate recovery of 1 minute (HRR1min) and heart rate recovery of 2 minutes (HRR2min) were calculated by the difference between the peak pulse rate during exercise and the resting pulse rate at 1 and 2 minutes, respectively. Analysis was done separately based on gender. Pearson correlation analysis was used to determine the association between the HRR parameters with body composition measures, while multiple regression analysis was used to determine which body composition measures was the strongest predictor for HRR.
RESULTS: For both gender groups, all body composition measures were inversely correlated with HRR1min. In girls, all body composition measures were inversely correlated with HRR2min, while in boys all body composition measures, except BMI z-score, were associated with HRR2min. In multiple regression, only waist circumference was inversely associated with HRR2min (p=0.024) in boys, while in girls it was body fat percentage for HRR2min (p=0.008).
CONCLUSION: There was an inverse association between body composition measurements and HRR among apparently healthy adolescents. Therefore, it is important to identify cardio-metabolic risk factors in adolescent as an early prevention of consequent adulthood morbidity. This reiterates the importance of healthy living which should start from young.

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