Transcriptional homeostasis relies on the balance between positive and negative regulation of gene transcription. Methylation of histone H3 lysine 9 (H3K9) is commonly correlated with gene repression. Here, we report that a euchromatic H3K9 methyltransferase, EHMT1, functions as a negative regulator in both the NF-κB- and type I interferon-mediated gene induction pathways. EHMT1 catalyzes H3K9 methylation at promoters of NF-κB target genes. Moreover, EHMT1 interacts with p50, and, surprisingly, p50 appears to repress the expression of type I interferon genes and genes activated by type I interferons by recruiting EHMT1 to catalyze H3K9 methylation at their promoter regions. Silencing the expression of EHMT1 by RNA interference enhances expression of a subset NF-κB-regulated genes, augments interferon production, and augments antiviral immunity.
The integrated development of pollution reduction, carbon reduction, greening, and growth (PR-CR-G-G) has become a crucial component of China's green transformation. Encouraging a virtuous cycle of these elements within the tourism sector not only supports the goals of "carbon peak" and "carbon neutrality" but also improves the overall quality of tourism and accelerates its green transformation. This study covers 30 provinces in China and develops an index system for Tourism PR-CR-G-G from 2011 to 2022. The coupled coordination degree model (CCD) is utilized to assess the level of synergistic development in these areas. Additionally, a modified gravity model is applied to establish a Tourism PR-CR-G-G Spatial correlation network. Social network analysis is then used to examine the characteristics and formation mechanisms of this network. The findings indicate that: 1) The overall coupling coordination value for tourism pollution reduction, carbon reduction, green expansion, and growth in China is on an upward trajectory, but significant spatial disparities exist, with the ranking being East (0.444) > Central (0.425) > Northeast (0.369) > West (0.365); 2) The spatial correlation within the synergistic development network of Tourism PR-CR-G-G in China is strong, displaying a high-level characteristic. A small number of provinces hold central positions, exerting a noticeable siphoning effect that reduces the overall network efficiency; 3) The network shows distinct grouping patterns, with each province having a clear functional role, creating a well-defined operational chain; 4) Quadratic assignment procedure (QAP) analysis shows that the generation of PR-CR-G-G network in China's tourism industry is positively correlated with the level of economic development, industry structure, external openness, and urbanization level and negatively correlated with technological development and geographical distance.
This study reports results from the first International Body Project (IBP-I), which surveyed 7,434 individuals in 10 major world regions about body weight ideals and body dissatisfaction. Participants completed the female Contour Drawing Figure Rating Scale (CDFRS) and self-reported their exposure to Western and local media. Results indicated there were significant cross-regional differences in the ideal female figure and body dissatisfaction, but effect sizes were small across high-socioeconomic-status (SES) sites. Within cultures, heavier bodies were preferred in low-SES sites compared to high-SES sites in Malaysia and South Africa (ds = 1.94-2.49) but not in Austria. Participant age, body mass index (BMI), and Western media exposure predicted body weight ideals. BMI and Western media exposure predicted body dissatisfaction among women. Our results show that body dissatisfaction and desire for thinness is commonplace in high-SES settings across world regions, highlighting the need for international attention to this problem.