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  1. Fulltext Effects of formulation parameters on particle size and polydispersity index of orthosiphon stamineus loaded nanostructured lipid carrier
    Suhaimi, S. H., Hasham @Hisam, R., Rosli, N. A.
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2016;1(1):36-39.
    MyJurnal
    This study was conducted to investigate the effect of particle size and polydispersity index
    (PDI) by changing the concentration of active ingredient and solid lipid in the Orthosiphon stamineus
    (O. stamineus) loaded nanostructured lipid carrier (NLC) formulation. O. stamineus extract was
    prepared by maceration method. From the HPLC analysis, the O. stamineus extract contains 38%
    sinensetin and 62% rosmarinic acid. The method used to prepare the formulation of O. Stamineus
    loaded NLC is melt emulsification homogenization technique. Solid and liquid lipid used were glyceryl
    monostearate and triglyceride respectively. It was found that the size of particles increased as
    increasing in concentration of active and solid lipid in the formulation. The best range for concentration
    of active and solid lipid are 1-4% and 1-3% respectively since the particle size and PDI needed are
    below 200 d.nm and 0.2. Collectively, based on particle size and PDI results show that the NLC system
    is highly potential to be a carrier of transdermal delivery for O. stamineus. Copyright © 2015 Penerbit
    Akademia Baru - All rights reserved
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