This study was conducted to investigate the effect of particle size and polydispersity index
(PDI) by changing the concentration of active ingredient and solid lipid in the Orthosiphon stamineus
(O. stamineus) loaded nanostructured lipid carrier (NLC) formulation. O. stamineus extract was
prepared by maceration method. From the HPLC analysis, the O. stamineus extract contains 38%
sinensetin and 62% rosmarinic acid. The method used to prepare the formulation of O. Stamineus
loaded NLC is melt emulsification homogenization technique. Solid and liquid lipid used were glyceryl
monostearate and triglyceride respectively. It was found that the size of particles increased as
increasing in concentration of active and solid lipid in the formulation. The best range for concentration
of active and solid lipid are 1-4% and 1-3% respectively since the particle size and PDI needed are
below 200 d.nm and 0.2. Collectively, based on particle size and PDI results show that the NLC system
is highly potential to be a carrier of transdermal delivery for O. stamineus. Copyright © 2015 Penerbit
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