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Cardiovascular biomarker troponin I biosensor: Aptamer-gold-antibody hybrid on a metal oxide surface

Hui H, Gopinath SCB, Ismail ZH, Chen Y, Pandian K, Velusamy P

Biotechnol Appl Biochem, 2023 Apr;70(2):581-591.
PMID: 35765758 DOI: 10.1002/bab.2380

Myocardial infarction (MI) is highly related to cardiac arrest leading to death and organ damage. Radiological techniques and electrocardiography have been used as preliminary tests to diagnose MI; however, these techniques are not sensitive enough for early-stage detection. A blood biomarker-based diagnosis is an immediate solution, and due to the high correlation of troponin with MI, it has been considered to be a gold-standard biomarker. In the present research, the cardiac biomarker troponin I (cTnI) was detected on an interdigitated electrode sensor with various surface interfaces. To detect cTnI, a capture aptamer-conjugated gold nanoparticle probe and detection antibody probe were utilized and compared through an alternating sandwich pattern. The surface metal oxide morphology of the developed sensor was proven by microscopic assessments. The limit of detection with the aptamer-gold-cTnI-antibody sandwich pattern was 100 aM, while it was 1 fM with antibody-gold-cTnI-aptamer, representing 10-fold differences. Further, the high performance of the sensor was confirmed by selective cTnI determination in serum, exhibiting superior nonfouling. These methods of determination provide options for generating novel assays for diagnosing MI.
Fulltext Bullying behavior and mental health among college students in Sichuan, China: a cross-sectional study

Jing Y, Cao R, Yang D, Liu Y, Zhang J, Hui H, et al.

Front Public Health, 2026;14:1889019.
PMID: 42935642 DOI: 10.3389/fpubh.2026.1889019

BACKGROUND: Bullying is a known risk factor for poor mental health in adolescents. Although bullying research has largely focused on adolescent populations, college students represent a distinct group warranting dedicated attention. They shoulder unique developmental tasks including academic competition and career preparation, and exhibit behavioral characteristics of frequent engagement with digital platforms. This study examined the prevalence of bullying and its associations with depression, anxiety, and post-traumatic stress disorder (PTSD).
METHODOLOGY: A cross-sectional survey was conducted among 1,120 students from August 18 to September 10, 2025. We recruited participants from a single college through class-based online channels using convenience sampling. Standardized scales assessed bullying experiences, anxiety, depression, PTSD symptoms, and psychological resilience.
RESULTS: A total of 241(21.5%) students reported being bullied, and 101(9.0%) reported bullying others. Mann-Whitney U tests showed no significant effects of age and ethnicity on the four mental health indicators (all p > 0.05). Gender and family residence groups exhibited statistically significant differences in GAD-7 and PHQ-9 scores; additionally, family residence groups differed in CD-RISC-25 scores (p 
Global review of COVID-19 mitigation strategies and their impact on cancer service disruptions

Shah R, Loo CE, Hanna NM, Hughes S, Mafra A, Fink H, et al.

J Cancer Policy, 2024 Jun 01;41:100486.
PMID: 38830535 DOI: 10.1016/j.jcpo.2024.100486

During the COVID-19 pandemic, countries adopted mitigation strategies to reduce disruptions to cancer services. We reviewed their implementation across health system functions and their impact on cancer diagnosis and care during the pandemic. A systematic search was performed using terms related to cancer and COVID-19. Included studies reported on individuals with cancer or cancer care services, focusing on strategies/programs aimed to reduce delays and disruptions. Extracted data were grouped into four functions (governance, financing, service delivery, and resource generation) and sub-functions of the health system performance assessment framework. We included 30 studies from 16 countries involving 192,233 patients with cancer. Multiple mitigation approaches were implemented, predominantly affecting sub-functions of service delivery to control COVID-19 infection via the suspension of non-urgent cancer care, modified treatment guidelines, and increased telemedicine use in routine cancer care delivery. Resource generation was mainly ensured through adequate workforce supply. However, less emphasis on monitoring or assessing the effectiveness and financing of these strategies was observed. Seventeen studies suggested improved service uptake after mitigation implementation, yet the resulting impact on cancer diagnosis and care has not been established. This review emphasizes the importance of developing effective mitigation strategies across all health system (sub)functions to minimize cancer care service disruptions during crises. Deficiencies were observed in health service delivery (to ensure equity), governance (to monitor and evaluate the implementation of mitigation strategies), and financing. In the wake of future emergencies, implementation research studies that include pre-prepared protocols will be essential to assess mitigation impact across cancer care services.
The global impact of the COVID-19 pandemic on delays and disruptions in cancer care services: a systematic review and meta-analysis

Shah R, Hanna NM, Loo CE, David M, Mafra A, Fink H, et al.

Nat Cancer, 2025 Jan;6(1):194-204.
PMID: 39747650 DOI: 10.1038/s43018-024-00880-4

The coronavirus disease 2019 pandemic substantially impacted the delivery of cancer services and programs. Here we reviewed and synthesized the global scale and impact of pandemic-related delays and disruptions on cancer services, including diagnosis, diagnostic procedures, screening, treatment and supportive and palliative care. Based on data from 245 articles in 46 countries, we observed declines in the number of cancer screening participation (39.0%), diagnoses (23.0%), diagnostic procedures (24.0%) and treatment (28.0%), ranging from a 15.0% decline for radiotherapy to a 35.0% decline for systemic treatment during the pandemic compared to during the prepandemic period. Medium-human development index (HDI) category countries experienced greater reductions than high- and very-high-HDI countries. Missing data from low-HDI countries emphasize the need for increased investments in cancer surveillance and research in these settings. PROSPERO registration: CRD42022301816.