The exponential distribution optimizer (EDO) represents a heuristic approach, capitalizing on exponential distribution theory to identify global solutions for complex optimization challenges. This study extends the EDO's applicability by introducing its multi-objective version, the multi-objective EDO (MOEDO), enhanced with elite non-dominated sorting and crowding distance mechanisms. An information feedback mechanism (IFM) is integrated into MOEDO, aiming to balance exploration and exploitation, thus improving convergence and mitigating the stagnation in local optima, a notable limitation in traditional approaches. Our research demonstrates MOEDO's superiority over renowned algorithms such as MOMPA, NSGA-II, MOAOA, MOEA/D and MOGNDO. This is evident in 72.58% of test scenarios, utilizing performance metrics like GD, IGD, HV, SP, SD and RT across benchmark test collections (DTLZ, ZDT and various constraint problems) and five real-world engineering design challenges. The Wilcoxon Rank Sum Test (WRST) further confirms MOEDO as a competitive multi-objective optimization algorithm, particularly in scenarios where existing methods struggle with balancing diversity and convergence efficiency. MOEDO's robust performance, even in complex real-world applications, underscores its potential as an innovative solution in the optimization domain. The MOEDO source code is available at: https://github.com/kanak02/MOEDO .
In this study, we tackle the challenge of optimizing the design of a Brushless Direct Current (BLDC) motor. Utilizing an established analytical model, we introduced the Multi-Objective Generalized Normal Distribution Optimization (MOGNDO) method, a biomimetic approach based on Pareto optimality, dominance, and external archiving. We initially tested MOGNDO on standard multi-objective benchmark functions, where it showed strong performance. When applied to the BLDC motor design with the objectives of either maximizing operational efficiency or minimizing motor mass, the MOGNDO algorithm consistently outperformed other techniques like Ant Lion Optimizer (ALO), Ion Motion Optimization (IMO), and Sine Cosine Algorithm (SCA). Specifically, MOGNDO yielded the most optimal values across efficiency and mass metrics, providing practical solutions for real-world BLDC motor design. The MOGNDO source code is available at: https://github.com/kanak02/MOGNDO.
This research introduces the Multi-Objective Liver Cancer Algorithm (MOLCA), a novel approach inspired by the growth and proliferation patterns of liver tumors. MOLCA emulates the evolutionary tendencies of liver tumors, leveraging their expansion dynamics as a model for solving multi-objective optimization problems in engineering design. The algorithm uniquely combines genetic operators with the Random Opposition-Based Learning (ROBL) strategy, optimizing both local and global search capabilities. Further enhancement is achieved through the integration of elitist non-dominated sorting (NDS), information feedback mechanism (IFM) and Crowding Distance (CD) selection method, which collectively aim to efficiently identify the Pareto optimal front. The performance of MOLCA is rigorously assessed using a comprehensive set of standard multi-objective test benchmarks, including ZDT, DTLZ and various Constraint (CONSTR, TNK, SRN, BNH, OSY and KITA) and real-world engineering design problems like Brushless DC wheel motor, Safety isolating transformer, Helical spring, Two-bar truss and Welded beam. Its efficacy is benchmarked against prominent algorithms such as the non-dominated sorting grey wolf optimizer (NSGWO), multiobjective multi-verse optimization (MOMVO), non-dominated sorting genetic algorithm (NSGA-II), decomposition-based multiobjective evolutionary algorithm (MOEA/D) and multiobjective marine predator algorithm (MOMPA). Quantitative analysis is conducted using GD, IGD, SP, SD, HV and RT metrics to represent convergence and distribution, while qualitative aspects are presented through graphical representations of the Pareto fronts. The MOLCA source code is available at: https://github.com/kanak02/MOLCA.
Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence. The molecular mechanisms of cue-induced relapse are not well established, despite the fact that they may offer new targets for the treatment of AUD. Using a comprehensive animal model of AUD, virally-mediated and amygdala-targeted genetic manipulations by CRISPR/Cas9 technology and ex vivo electrophysiology, we identify a mechanism that selectively controls cue-induced alcohol relapse and AUD symptom severity. This mechanism is based on activity-regulated cytoskeleton-associated protein (Arc)/ARG3.1-dependent plasticity of the amygdala synapses. In humans, we identified single nucleotide polymorphisms in the ARC gene and their methylation predicting not only amygdala size, but also frequency of alcohol use, even at the onset of regular consumption. Targeting Arc during alcohol cue exposure may thus be a selective new mechanism for relapse prevention.