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A Bayesian-Inspired Item Response Theory-Based Framework to Produce Very Short Versions of MacArthur-Bates Communicative Development Inventories

Chai JH, Lo CH, Mayor J

J Speech Lang Hear Res, 2020 10 16;63(10):3488-3500.
PMID: 32897770 DOI: 10.1044/2020_JSLHR-20-00361

Purpose This study introduces a framework to produce very short versions of the MacArthur-Bates Communicative Development Inventories (CDIs) by combining the Bayesian-inspired approach introduced by Mayor and Mani (2019) with an item response theory-based computerized adaptive testing that adapts to the ability of each child, in line with Makransky et al. (2016). Method We evaluated the performance of our approach-dynamically selecting maximally informative words from the CDI and combining parental response with prior vocabulary data-by conducting real-data simulations using four CDI versions having varying sample sizes on Wordbank-the online repository of digitalized CDIs: American English (a very large data set), Danish (a large data set), Beijing Mandarin (a medium-sized data set), and Italian (a small data set). Results Real-data simulations revealed that correlations exceeding .95 with full CDI administrations were reached with as few as 15 test items, with high levels of reliability, even when languages (e.g., Italian) possessed few digitalized administrations on Wordbank. Conclusions The current approach establishes a generic framework that produces very short (less than 20 items) adaptive early vocabulary assessments-hence considerably reducing their administration time. This approach appears to be robust even when CDIs have smaller samples in online repositories, for example, with around 50 samples per month-age.
Tablet assessment of word comprehension reveals coarse word representations in 18-⁠20-month-old toddlers

Lo CH, Rosslund A, Chai JH, Mayor J, Kartushina N

Infancy, 2021 07;26(4):596-616.
PMID: 33813801 DOI: 10.1111/infa.12401

The present study explores the viability of using tablets in assessing early word comprehension by means of a two-alternative forced-choice task. Forty-nine 18-20-month-old Norwegian toddlers performed a touch-based word recognition task, in which they were prompted to identify the labeled target out of two displayed items on a touchscreen tablet. In each trial, the distractor item was either semantically related (e.g., dog-cat) or unrelated (e.g., dog-airplane) to the target. Our results show that toddlers as young as 18 months can engage meaningfully with a tablet-based assessment, with minimal verbal instruction and child-administrator interaction. Toddlers performed better in the semantically unrelated condition than in the related condition, suggesting that their word representations are still semantically coarse at this age. Furthermore, parental reports of comprehension, using the Norwegian version of the MacArthur-Bates Communicative Development Inventories, predicted toddlers' performance, with parent-child agreement stronger in the semantically unrelated condition, indicating that parents declare a word to be known by their child if it is understood at a coarse representational level. This study provides among the earliest evidence that remote data collection in 18-20 month-old toddlers is viable, as comparable results were observed from both in-laboratory and online administration of the touchscreen recognition task.
e-Babylab: An open-source browser-based tool for unmoderated online developmental studies

Lo CH, Hermes J, Kartushina N, Mayor J, Mani N

Behav Res Methods, 2023 Aug 24.
PMID: 37620744 DOI: 10.3758/s13428-023-02200-7

The COVID-19 pandemic massively changed the context and feasibility of developmental research. This new reality, as well as considerations about sample diversity and naturalistic settings for developmental research, highlights the need for solutions for online studies. In this article, we present e-Babylab, an open-source browser-based tool for unmoderated online studies targeted for young children and babies. e-Babylab offers an intuitive graphical user interface for study creation and management of studies, users, participant data, and stimulus material, with no programming skills required. Various kinds of audiovisual media can be presented as stimuli, and possible measures include webcam recordings, audio recordings, key presses, mouse-click/touch coordinates, and reaction times. An additional feature of e-Babylab is the possibility to administer short adaptive versions of MacArthur-Bates Communicative Development Inventories (Chai et al. Journal of Speech, Language, and Hearing Research, 63, 3488-3500, 2020). Information pages, consent forms, and participant forms are customizable. e-Babylab has been used with a variety of measures and paradigms in over 12 studies with children aged 12 months to 8 years (n = 1516). We briefly summarize some results of these studies to demonstrate that data quality, participant engagement, and overall results are comparable between laboratory and online settings. Finally, we discuss helpful tips for using e-Babylab and present plans for upgrades.
Fulltext Word learning from a tablet app: Toddlers perform better in a passive context

Ackermann L, Lo CH, Mani N, Mayor J

PLoS One, 2020;15(12):e0240519.
PMID: 33259476 DOI: 10.1371/journal.pone.0240519

In recent years, the popularity of tablets has skyrocketed and there has been an explosive growth in apps designed for children. Howhever, many of these apps are released without tests for their effectiveness. This is worrying given that the factors influencing children's learning from touchscreen devices need to be examined in detail. In particular, it has been suggested that children learn less from passive video viewing relative to equivalent live interaction, which would have implications for learning from such digital tools. However, this so-called video deficit may be reduced by allowing children greater influence over their learning environment. Across two touchscreen-based experiments, we examined whether 2- to 4-year-olds benefit from actively choosing what to learn more about in a digital word learning task. We designed a tablet study in which "active" participants were allowed to choose which objects they were taught the label of, while yoked "passive" participants were presented with the objects chosen by their active peers. We then examined recognition of the learned associations across different tasks. In Experiment 1, children in the passive condition outperformed those in the active condition (n = 130). While Experiment 2 replicated these findings in a new group of Malay-speaking children (n = 32), there were no differences in children's learning or recognition of the novel word-object associations using a more implicit looking time measure. These results suggest that there may be performance costs associated with active tasks designed as in the current study, and at the very least, there may not always be systematic benefits associated with active learning in touchscreen-based word learning tasks. The current studies add to the evidence that educational apps need to be evaluated before release: While children might benefit from interactive apps under certain conditions, task design and requirements need to consider factors that may detract from successful performance.
Fulltext Density of breast: An independent risk factor for developing breast cancer, a prospective study at two premium breast centers

Lo CH, Chai XY, Ting SSW, Ang SC, Chin X, Tan LT, et al.

Cancer Med, 2020 05;9(9):3244-3251.
PMID: 32130790 DOI: 10.1002/cam4.2821

BACKGROUND: Breast cancer is the leading cause of death among women worldwide. Studies have identified breast density as a controversial risk factor of breast cancer. Moreover, studies found that breast density reduction through Tamoxifen could reduce risk of breast cancer significantly. To date, no study on the association between breast density and breast cancer has been carried out in Malaysia. If breast density is proven to be a risk factor of breast cancer, intervention could be carried out to reduce breast cancer risk through breast density reduction.
PURPOSE: To determine if density of breast is an independent risk factor which will contribute to development of breast cancer.
MATERIALS AND METHODS: A prospective cohort study is carried out in two hospitals targeting adult female patients who presented to the Breast Clinic with symptoms suspicious of breast cancer. Participants recruited were investigated for breast cancer based on their symptoms. Breast density assessed from mammogram was correlated with tissue biopsy results and final diagnosis of benign or malignant breast disease.
RESULTS: Participants with dense breasts showed 29% increased risk of breast cancer when compared to those with almost entirely fatty breasts (odds ratio [OR] 1.29, 95% CI 0.38-4.44, P = .683). Among the postmenopausal women, those with dense breasts were 3.1 times more likely to develop breast cancer compared with those with fatty breasts (OR 3.125, 95% CI 0.72-13.64, P = .13). Moreover, the chance of developing breast cancer increases with age (OR 1.046, 95% CI 1.003-1.090, P
Fulltext Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.

Autophagy, 2021 Jan;17(1):1-382.
PMID: 33634751 DOI: 10.1080/15548627.2020.1797280

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.