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  1. Fulltext EFFECTS OF TANK COLOUR ON BODY COLOUR INTENSITY AND GROWTH OF YELLOW GOURAMI Trichopodus trichopterus
    Asra Nor Izaty, A., Norazmi-Lokman, N. H.
    UMT Journal of Undergraduate Research, 2019;1(4):9-18.
    MyJurnal
    Yellow gourami (Trichopodus trichopterus) is a species native to Southeast Asia and is famous as ornamental species. However, hobbyists and farmers encounter problems where its body colour easily becomes faded in captivity. Since colour enhancer pellets are expensive, an experiment was performed to determine whether tank colour can influence the body colour intensity and growth of T. trichopterus. Four different tank colours (white, yellow, blue and green) with five replicates were tested where fish were kept under natural lighting (outdoor) conditions for two months. The results demonstrated that fish reared in green coloured tank showed an increment in its colour intensity while fish reared in white tanks increased its body weight. It can be concluded that tank colour does affect the body colour intensity and weight of T. trichopterus. This study will help farmers and hobbyists to solve colour fading problem using a cheaper way.
  2. Trends and projections of mild and moderate hearing loss among adolescents, young adults, middle-aged adults and age-standardised population in Malaysia from 1996 to 2030
    Lokman N, Rasidi WNA
    Eur Arch Otorhinolaryngol, 2024 Jul 08.
    PMID: 38977482 DOI: 10.1007/s00405-024-08796-6
    PURPOSE: This study aims to assess the prevalence of mild and moderate hearing loss spanning three decades, from 1990 to 2019, and to project the anticipated trends from 2020 to 2030 among adolescents, young adults, middle-aged adults, and age-standardised groups in Malaysia.

    METHODS: This study involved secondary data analysis of mild and moderate hearing loss prevalence over 30 years among the Malaysian population aged 15-19, 25-29, 35-39, 45-49, and age-standardised groups. Subsequently, three time-series models were evaluated and the best models with the minimal Mean Absolute Percentage Error (MAPE) and Root Mean Squared Error (RMSE) were selected for projecting the prevalence of hearing loss until 2030.

    RESULTS: A relatively stable trend of mild hearing loss prevalence and gradual decline of moderate hearing loss were observed across all age groups throughout the study period. The prevalence of mild hearing loss was consistently higher than moderate hearing loss across all age groups, with its prevalence increasing with age. The projected prevalence of hearing loss exhibits a gradual declining trend in the future for all age groups, except for mild hearing loss for the 15-19-year-old group.

    CONCLUSION: Over the past 30 years, there has been a relatively stable and slightly declining trend in the prevalence of mild and moderate hearing loss among the Malaysian population, respectively with projections showing a slow reduction in the future. These findings highlighted the need for identifying the best intervention and vulnerable age groups, directing increased resources and prioritization towards them.

  3. Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer
    Shakya R, Tarulli GA, Sheng L, Lokman NA, Ricciardelli C, Pishas KI, et al.
    Oncogene, 2017 08;36(31):4469-4480.
    PMID: 28368395 DOI: 10.1038/onc.2017.66
    Missense mutations in the TP53 tumor-suppressor gene inactivate its antitumorigenic properties and endow the incipient cells with newly acquired oncogenic properties that drive invasion and metastasis. Although the oncogenic effect of mutant p53 transcriptome has been widely acknowledged, the global influence of mutant p53 on cancer cell proteome remains to be fully elucidated. Here, we show that mutant p53 drives the release of invasive extracellular factors (the 'secretome') that facilitates the invasion of lung cancer cell lines. Proteomic characterization of the secretome from mutant p53-inducible H1299 human non-small cell lung cancer cell line discovered that the mutant p53 drives its oncogenic pathways through modulating the gene expression of numerous targets that are subsequently secreted from the cells. Of these genes, alpha-1 antitrypsin (A1AT) was identified as a critical effector of mutant p53 that drives invasion in vitro and in vivo, together with induction of epithelial-mesenchymal transition markers expression. Mutant p53 upregulated A1AT transcriptionally through the involvement with its family member p63. Conditioned medium containing secreted A1AT enhanced cell invasion, while an A1AT-blocking antibody attenuated the mutant p53-driven migration and invasion. Importantly, high A1AT expression correlated with increased tumor stage, elevated p53 staining and shorter overall survival in lung adenocarcinoma patients. Collectively, these findings suggest that A1AT is an indispensable target of mutant p53 with prognostic and therapeutic potential in mutant p53-expressing tumors.
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