MATERIALS AND METHODS: Kepok banana peel was macerated using 70% ethanol. The extract is made in the form of a gel formulation because it has a high water content so it can moisturise the skin and spread easily when applied. This research was conducted with 25 male rats in 5 treatment groups. The gel was given 30 minutes after the rats were induced with 0.1 ml of 1% carrageenan. The rat antiinflammatory test was observed through oedema volume data and the percentage of anti-inflammatory activity. Data analysis used the ANOVA test (p<0.05).
RESULTS: The treatment group had an anti-inflammatory effect which was marked by a significant difference from the negative control group.
CONCLUSION: The effective dose of ethanol extract gel of kepok banana peel as an anti-inflammatory is 8%.
OBJECTIVE: This study aims to identify and compare photoaging rat models exposed to UVA and UVB.
METHODS: This research method compared macroscopic (scoring degree of wrinkling) and microscopic (histology) signs and symptoms on skin samples of rat exposed to UVA and UVB for 4 weeks at a radiation dose of 840mJ/cm2.
RESULTS: The results of this study indicated that the degree of wrinkling was highest in rat skin exposed to UVB rays by 51% (p<0.05). UVB histological results showed that the epidermis layer (40 µm, p<0.05) was thickened and the dermis layer (283 µm, p<0.05) was thinned in the skin of mice exposed to UVB light. The UVB group, showed the density of collagen in the dermis with a mean value of 55% (p<0.05).
CONCLUSION: Our results suggest that short-term exposure to UVB radiation (in the acute, subacute or subchronic phase) induces more rapid and pronounced damage to rat skin when compared to UVA radiation exposure.