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  1. Mayangsari E, Mustika A, Nurdiana N, Ardhayudicva S
    Med J Malaysia, 2023 Jul;78(4):488-490.
    PMID: 37518917
    INTRODUCTION: Inflammation is the body's defense response to foreign invasion, tissue damage or both. Flavonoid compounds have anti-inflammatory activity. One of the traditional medicines is Kepok banana peel (Musa balbisiana) contains flavonoids, saponins and triterpenoids. This study aims to determine the effective dose of ethanol extract of kepok banana peel as an anti-inflammatory.

    MATERIALS AND METHODS: Kepok banana peel was macerated using 70% ethanol. The extract is made in the form of a gel formulation because it has a high water content so it can moisturise the skin and spread easily when applied. This research was conducted with 25 male rats in 5 treatment groups. The gel was given 30 minutes after the rats were induced with 0.1 ml of 1% carrageenan. The rat antiinflammatory test was observed through oedema volume data and the percentage of anti-inflammatory activity. Data analysis used the ANOVA test (p<0.05).

    RESULTS: The treatment group had an anti-inflammatory effect which was marked by a significant difference from the negative control group.

    CONCLUSION: The effective dose of ethanol extract gel of kepok banana peel as an anti-inflammatory is 8%.

  2. Mayangsari E, Mustika A, Nurdiana N, Samad NA
    Med Arch, 2024;78(2):88-91.
    PMID: 38566862 DOI: 10.5455/medarh.2024.78.88-91
    BACKGROUND: Prolonged exposure to sunlight is known to induce photoaging of the skin, leading to various skin changes and disorders, such as dryness, wrinkles, irregular pigmentation, and even cancer. Ultraviolet A (UVA) and ultraviolet B (UVB) radiation are particularly responsible for causing photoaging.

    OBJECTIVE: This study aims to identify and compare photoaging rat models exposed to UVA and UVB.

    METHODS: This research method compared macroscopic (scoring degree of wrinkling) and microscopic (histology) signs and symptoms on skin samples of rat exposed to UVA and UVB for 4 weeks at a radiation dose of 840mJ/cm2.

    RESULTS: The results of this study indicated that the degree of wrinkling was highest in rat skin exposed to UVB rays by 51% (p<0.05). UVB histological results showed that the epidermis layer (40 µm, p<0.05) was thickened and the dermis layer (283 µm, p<0.05) was thinned in the skin of mice exposed to UVB light. The UVB group, showed the density of collagen in the dermis with a mean value of 55% (p<0.05).

    CONCLUSION: Our results suggest that short-term exposure to UVB radiation (in the acute, subacute or subchronic phase) induces more rapid and pronounced damage to rat skin when compared to UVA radiation exposure.

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