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Fulltext Antioxidant, antityrosinase, anticholinesterase, and nitric oxide inhibition activities of three malaysian macaranga species

Mazlan NA, Mediani A, Abas F, Ahmad S, Shaari K, Khamis S, et al.

ScientificWorldJournal, 2013;2013:312741.
PMID: 24319356 DOI: 10.1155/2013/312741

The methanol extracts of three Macaranga species (M. denticulata, M. pruinosa, and M. gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. denticulata showed the highest total phenolic content (2682 mg gallic acid equivalent (GAE)/100 g) and free radical scavenging activity (IC50 = 0.063 mg/mL). All of the samples inhibited linoleic acid peroxidation by greater than 80%, with the leaves of M. gigantea exhibiting the highest inhibition of 92.21%. Most of the samples exhibited significant antioxidant potential. The bark of M. denticulata and the leaves of both M. pruinosa and M. gigantea exhibited greater than 50% tyrosinase inhibition, with the bark of M. denticulata having the highest percentage of inhibition (68.7%). The bark and leaves of M. denticulata exhibited greater than 50% inhibition (73.82% and 54.50%, resp.) of the acetylcholinesterase enzyme (AChE), while none of the samples showed any significant inhibition of butyrylcholinesterase (BChE). Only the bark of M. denticulata and M. gigantea displayed greater than 50% inhibition of nitric oxide production in cells (81.79% and 56.51%, resp.). These bioactivities indicate that some Macaranga spp. have therapeutic potential in medicinal research.
Fulltext 2-Cyclo-hexyl-idene-N-methyl-hydrazine-carbothio-amide

Tayamon S, Mazlan NA, Ravoof TB, Mohamed Tahir MI, Crouse KA

Acta Crystallogr Sect E Struct Rep Online, 2012 Nov 1;68(Pt 11):o3104-5.
PMID: 23284431 DOI: 10.1107/S1600536812042018

The title compound C(8)H(15)N(3)S has two mol-ecules in the asymmetric unit in which cis-trans isomerism is exhibited around the N(NH)C=S bonds. The cyclo-hexyl rings in both mol-ecules adopt a chair conformation. In the crystal, N-H⋯S hydrogen bonding produces dimers, which are inter-connected through further N-H⋯S hydrogen bonds, forming chains along the b-axis direction.
Fulltext Research on Nonsteroidal Anti-inflammatory Drugs in Malaysia: A Bibliometric Analysis

Zin CS, Nozid NR, Razak AA, Hashim SN, Mazlan NA, Daud N, et al.

J Pharm Bioallied Sci, 2020 Nov;12(Suppl 2):S707-S710.
PMID: 33828365 DOI: 10.4103/jpbs.JPBS_282_19

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common analgesics used for pain relief. Adverse effects of NSAIDs range from gastrointestinal tract disturbances to increased risk of bleeding, renal injury, and myocardial infarction. In Malaysia, the research productivity of NSAIDs is not well explored.
Objective: This study examined research productivity of NSAIDs in Malaysia.
Materials and Methods: This bibliometric study included all published research articles on NSAIDs from 1979 to 2018, which were conducted in Malaysia. The search databases such as Google Scholar, PubMed, ScienceDirect, and Scopus were used. Search terms included NSAIDs and specific drug names such as ibuprofen, celecoxib, and naproxen. Growth of publication, authorship pattern, citation analysis, journal index, type of studies, and geographical distribution of institutions publishing articles on NSAIDs were measured.
Results: Overall, 111 articles were retrieved from 1979 to 2018. The annual productivity of articles throughout the study fluctuated in which the highest productivity was in 2018, 12.61% (n = 14). Majority of articles were multiple authored, 99.10% (n = 109), and University of Science Malaysia (USM) produced the highest number of articles (30 articles). Most of the articles were International Scientific Indexing-indexed, 52.25% (n = 58), and the main issue studied in most of the articles was the drug formulation of NSAIDs.
Conclusion: The growth of NSAID research in Malaysia was slow, and the majority of research involved laboratory studies. Clinical studies evaluating the clinical outcomes of NSAIDs in patients, particularly using large healthcare databases are still lacking.
Fulltext COVID-19 Restriction Movement Control Order (MCO) Impacted Emissions of Peninsular Malaysia Using Sentinel-2a and Sentinel-5p Satellite

Mazlan NA, Zaki NAM, Narashid RH, Talib N, Manokaran J, Arshad FC, et al.

Earth Syst Environ, 2023;7(1):347-358.
PMID: 36247032 DOI: 10.1007/s41748-022-00329-7

The unprecedented outbreak of Coronavirus Disease 2019 (COVID-19) has impacted the whole world in every aspect including health, social life, economic activity, education, and the environment. The pandemic has led to an improvement in air quality all around the world, including in Malaysia. Lockdowns have resulted in industry shutting down and road travel decreasing which can reduce the emission of Greenhouse Gases (GHG) and air pollution. This research assesses the impact of the COVID-19 lockdown on emissions using the Air Pollution Index (API), aerosols, and GHG which is Nitrogen Dioxide (NO2) in Malaysia. The data used is from Sentinel-5p and Sentinel-2A which monitor the air quality based on Ozone (O3) and NO2 concentration. Using an interpolated API Index Map comparing 2019, before the implementation of a Movement Control Order (MCO), and 2020, after the MCO period we examine the impact on pollution during and after the COVID-19 lockdown. Data used Sentinel-5p, Sentinel-2A, and Air Pollution Index of Malaysia (APIMS) to monitor the air quality that contains NO2 concentration. The result has shown the recovery in air quality during the MCO implementation which indirectly shows anthropogenic activities towards the environmental condition. The study will help to enhance and support the policy and scope for air pollution management strategies as well as raise public awareness of the main causes that contribute to air pollution.